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Method for testing content of magnesium in omeprazole magnesium raw material medicine

A technology for omeprazole magnesium and magnesium content, applied in the field of chemical analysis, can solve problems such as low precision and accuracy, inconsistent methods, etc., and achieve the effect of good precision and accuracy

Inactive Publication Date: 2017-05-31
SUZHOU TESTAR TESTING TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The purpose is to overcome the defects of inconsistent methods, low precision and accuracy in the prior art

Method used

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  • Method for testing content of magnesium in omeprazole magnesium raw material medicine
  • Method for testing content of magnesium in omeprazole magnesium raw material medicine
  • Method for testing content of magnesium in omeprazole magnesium raw material medicine

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Experimental program
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Embodiment 1

[0018] Sample processing:

[0019] Test solution: accurately weigh 0.2500g (accurate to 0.0001g) of the crushed sample and place it in a 50ml beaker, add 20ml of 1mol / L hydrochloric acid, stir to dissolve it, transfer to a 100ml volumetric flask, and add water to the volume. Scale, shake well, and let stand for 30min; accurately measure 5.0ml to a 100ml volumetric flask, add water to dilute to the mark; then accurately measure 10.0ml from the diluent to a 100ml volumetric flask, add 4ml of lanthanum solution and dilute to the mark with water , Shake well, measure on the machine. At the same time, make a reagent blank. Using the magnesium standard curve, an atomic absorption spectrophotometer was used to determine the magnesium content.

[0020] The working conditions of the instrument are as follows: spectral bandwidth: 0.4nm, negative high voltage 589.50V, lamp current 2.0mA, gas flow rate 1500mL / min, burner height 6.0nm, burner position 5.0nm, wavelength 285.2nm, measurement me...

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Abstract

The invention relates to a method for testing the content of magnesium in an omeprazole magnesium raw material medicine by using a flame atomic absorption spectrum method. According to the method, a sample is pretreated, a standard magnesium curve is prepared, and the content of magnesium is accurately tested by using the flame atomic absorption spectrum method, optimal operation process parameters can be confirmed, the method is high in analysis sensitivity and accuracy and has the advantages that the sample treatment process is simple, interference factors in testing are reduced, good operability is achieved, and the like, and accurate data can be provided to the omeprazole magnesium medicine control process.

Description

Technical field [0001] The invention specifically relates to a method for determining the magnesium content in omeprazole magnesium, which belongs to the field of chemical analysis methods. Background technique [0002] Omeprazole magnesium is clinically used for heartburn and acid reflux caused by hyperacidity. The second part of the Chinese Pharmacopoeia (2015 edition) includes omeprazole magnesium enteric-coated tablets, which are classified as proton pump inhibitors. However, the current 2015 edition of the Chinese Pharmacopoeia does not include omeprazole magnesium raw materials. Therefore, it is necessary to study the quality standards of omeprazole magnesium API. The research and detection methodology should meet the requirements of the fourth part of the People’s Republic of China Pharmacopoeia (2015 edition) to ensure the consistency and reliability of the produced omeprazole magnesium API. . The present invention uses flame atomic absorption spectrometry to determine ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31
CPCG01N21/3103
Inventor 司文会方志成郑丽卿崔锦良
Owner SUZHOU TESTAR TESTING TECH