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Medicine containing survivin inhibitor and ire1 inhibitor and use thereof

A technology of inhibitors and drugs, applied in the field of biomedicine, to achieve good synergy, definite curative effect, and low toxicity

Active Publication Date: 2019-05-17
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Currently, the combination of YM155 and STF-083010 has not been reported

Method used

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  • Medicine containing survivin inhibitor and ire1 inhibitor and use thereof
  • Medicine containing survivin inhibitor and ire1 inhibitor and use thereof
  • Medicine containing survivin inhibitor and ire1 inhibitor and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, the raw material formula of pharmaceutical composition of the present invention

[0030] Composition 1: YM155 and STF-083010, the molar concentration ratio of YM155 and STF-083010 is 0.05:60.

[0031] Composition 2: YM155 and STF-083010, the molar concentration ratio of YM155 and STF-083010 is 0.01:10.

[0032] Composition 3: YM155 and STF-083010, the molar concentration ratio of YM155 and STF-083010 is 0.5:80.

Embodiment 2

[0033] Embodiment 2, antitumor effect and experiment

[0034] Study 1: Effects of YM155 and STF-083010 alone on the growth of esophageal cancer cells

[0035] Detection of esophageal cancer cells Eca-109 and Kyse140 against YM155 or STF-083010 alone medication drug sensitivity.

[0036] 1.1 Experimental method

[0037] Tumor cells were divided into 4-6×10 per well 3 The number of cells was inoculated into a 96-well plate. After the cells adhered to the wall (24h), the YM155 and STF-083010 drugs were diluted to a certain gradient concentration, and each concentration was set to 5 replicate holes, and the drug was added to the experimental group and the zero adjustment group. . After 48 hours, use the MTT method to detect cell viability. Add 10 μl of MTT solution to each well and continue to incubate for 4 hours. Carefully suck out the liquid in the wells to avoid contact with crystals in the wells. Add 100 μl of DMSO to each well and shake on a constant speed shaker in...

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Abstract

The invention belongs to the field of bio-medicine, and particularly relates to drug containing a Survivin-containing inhibitor and an IRE1 inhibitor. An optimal embodiment discloses drug containing YM155 and STF-083010 in effective amounts. The drug can effectively improve toxic and side effect of YM155, and combined use of YM155 and STF-083010 has synergistic effect on treating lung cancer, liver cancer and esophagus cancer and is obviously better than single use of YM155 or STF-083010, which is proved by anti-tumor effect and in experiment results; especially, when a molar ratio of YM155 and STF-083010 is 0.05:60, synergism is quite good, and the drug has minimum toxic and side effect on normal cells.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to medicines containing Survivin inhibitors and IRE1 inhibitors and their application. Background technique [0002] Cancer is a disease with a high mortality rate second only to cardiovascular diseases, and the number of cancer patients and deaths worldwide is increasing. Nearly half of the new cancer cases occurred in Asia, most of which were in China, which ranked first in the world in terms of new cancer cases. Especially in the four types of malignant tumors including liver cancer, esophageal cancer, gastric cancer and lung cancer, China ranks first in the number of new cases and deaths in the world. Although the treatment of these cancers is mainly based on surgery, since early patients generally have no obvious symptoms, many of the cancer patients diagnosed for the first time are already in the middle and advanced stages and have lost the chance of surgical resection. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/497A61K31/381A61P35/00
CPCA61K31/381A61K31/497A61K45/06A61K2300/00
Inventor 王晓王绍祥王一飞钟雪云王绍其王熙昊
Owner JINAN UNIVERSITY
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