Method for controlling liquid drops by virtue of micro-electromagnetic bar

Abstract

The invention relates to a method for controlling liquid drops by virtue of a micro-electromagnetic bar. According to the method, a micro-electromagnetic bar and a substrate which are subjected to super-hydrophobic surface treatment are taken as platforms based on competition of magnetic force, surface tension and gravity, the micro-electromagnetic bar is switched on or off so as to absorb and release magnetic bead-containing liquid drops on the surface of a super-hydrophobic surface, and the operations of transportation, fusion and mixing of the magnetic bead-containing liquid drops and the control of the separation between solid-phase magnetic beads and liquid-phase magnetic beads in the magnetic bead-containing liquid drops are finished by virtue of placement of the micro-electromagnetic bar or a liquid drop seating platform. According to the method for controlling the liquid drops by virtue of the micro-electromagnetic bar, the liquid drops can be rapidly and flexibly controlled, and the actual application and rapid development of a digital microfluidic technique are hopefully promoted.

Description

technical field [0001] The invention belongs to the technical field of microfluidics, and relates to a method for manipulating liquid droplets by using a micro-electromagnetic rod. Background technique [0002] Digital Microfluidics based on droplet manipulation has the ability to control a single droplet, with good controllability, low energy consumption, no need for complex micropumps and microvalve structures, and can be applied to high integration, multi-step The micro-biochemical analysis process with complex operations has received extensive attention in the field of micro-biological and chemical analysis in recent years, and has become one of the most active fields in the development of microfluidic technology. [0003] At present, digital microfluidic technology mainly uses electrowetting to control the sample droplets. The electrowetting driving method is to change the wetting characteristics of the dielectric film and the surface liquid by applying a potential to t...

AI Technical Summary

Problems solved by technology

Both methods have their own limitations. Due to the relatively large volume of the magnet, the permanent magnet method is difficult to achieve high-resolution manipulation of a single target droplet in multiple densely arranged magnetic droplets, and it is difficult to achieve real-time microscopic optical observation; and The integrated micro-magnetic coil method requires complex and expensive micro-processing processes to make chips, which is expensive and not conducive to wide application

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