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Preparation method of creatine phosphate sodium

A technology of sodium creatine phosphate and sodium hydroxide, which is applied in the field of medicine and can solve problems such as poor fluidity of creatine phosphate sodium

Active Publication Date: 2017-06-13
哈尔滨莱博通药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of creatine in the obtained sodium creatine phosphate is greater than 0 and less than or equal to 0.1%, the content of creatinine is greater than 0 and less than or equal to 0.1%, and the content of creatinine phosphate is greater than 0 and less than or equal to 0.05%; the product quality is significantly improved; the sodium creatine phosphate obtained by the present invention, It also solves the problem of poor fluidity of creatine phosphate sodium obtained by the prior art

Method used

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  • Preparation method of creatine phosphate sodium
  • Preparation method of creatine phosphate sodium
  • Preparation method of creatine phosphate sodium

Examples

Experimental program
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Effect test

Embodiment 1

[0045]Take 200ml of water for injection, add 200g of creatine phosphate sodium ring-opening intermediate, stir and dissolve at 10°C, add 5% sodium hydroxide solution to adjust the pH value to 9.5, add 40g of diethanolamine, heat up to 40°C, stir for 30 minutes, cool down to 10°C ℃, add 1‰ activated carbon, stir and adsorb for 25 minutes, filter, add 5 times the solution volume of absolute ethanol to the solution, stir, crystallize at 0°C, filter, wash the crystals with ethanol, and dry under vacuum at 20°C to obtain phosphoric acid Sodium acid 193.7g.

Embodiment 2

[0047] Take 300ml of water for injection, add 300g of creatine phosphate sodium ring-opening intermediate, stir and dissolve at 30°C, add 5% sodium hydroxide solution to adjust the pH value to 10.5, add 195g of diethanolamine, heat up to 50°C, stir for 40 minutes, and cool down to 20°C ℃, add 3‰ activated carbon, stir and adsorb for 35 minutes, filter, add ethanol 9 times the volume of the solution to the solution, stir, crystallize at 10°C, filter, wash the crystals with absolute ethanol, and dry under vacuum at 40°C to obtain phosphophosphorus Sodium acid 276.2g.

Embodiment 3

[0049] Take 250ml of water for injection, add 250g of creatine phosphate sodium ring-opening intermediate, stir and dissolve at 20°C, add 5% sodium hydroxide solution to adjust the pH value to 10, add 112.5g of diethanolamine, heat up to 45°C, stir for 35 minutes, and cool down to Add 2‰ activated carbon at 15°C, stir and adsorb for 30 minutes, filter, add absolute ethanol 7 times the volume of the solution to the solution, stir, crystallize at 5°C, filter, wash the crystals with ethanol, and dry under vacuum at 30°C to obtain phosphoric acid Sodium creatine 235.1g.

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Abstract

The invention belongs to the technical field of medicine, and discloses a preparation method of creatine phosphate sodium. According to the method, a creatine phosphate sodium open loop intermediate product is used as a raw material; sodium hydroxide is added for pH value regulation; diethanolameine is added; the temperature is firstly raised and is then reduced; active carbon is added; after the filtering, absolute ethyl alcohol is added; still standing and filtering are performed; the creatine phosphate sodium is obtained; the kreatine content in the obtained creatine phosphate sodium is greater than 0 but smaller than or equal to 0.1 percent; the creatinine content is greater than 0 but smaller than or equal to 0.1 percent; the phosphocreatinine content is greater than 0 but smaller than or equal to 0.05 percent. The product quality is obviously improved. The obtained creatine phosphate sodium also solves the problem of poor flowability of the creatine phosphate sodium obtained in the prior art.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a new preparation method of creatine phosphate sodium. Background technique [0002] Phosphocreatine is a natural active substance in the human body, designed to replenish energy for ATP, which is the most important energy source in any cellular metabolic process. Exogenous phosphocreatine is a drug with cardioprotective effect, and it can be used as an important therapeutic drug to reduce ischemic myocardial damage, ventricular arrhythmia and improve failure during the whole process of cardiac surgery. Especially after the wide application of thrombolytic therapy for myocardial infarction, percutaneous transluminal coronary angioplasty (intracoronary stent) and coronary artery bypass grafting, it has driven the rapid growth of the creatine phosphate market and has become a major market for myocardial protection and Energy Supplements - Alternatives to Fructose Diph...

Claims

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Application Information

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IPC IPC(8): C07F9/22
CPCC07F9/222
Inventor 张士花黄靖安张志钢韩辉张楠
Owner 哈尔滨莱博通药业有限公司