Pharmaceutical composition and preparation method thereof

[0047] Example 1

[0048]

[0049] Preparation method: Weigh the raw and auxiliary materials in the prescription amount, crush them, sieving them for later use; mix the fumaric acid and voronolazan fumaric acid evenly to obtain the mixture ①; the mixture ①, polyprezinc, and hardened Other auxiliary materials other than magnesium fatty acid are put into the high-efficiency wet granulator and premixed for 15 minutes; into the high-efficiency wet granulator, slowly add 50% by volume ethanol solution to make soft materials; use the swing granulator to The prepared soft material is granulated with a 24-mesh sieve; the prepared wet granules are put into a hot-air circulating oven and dried at 55-65℃ until the moisture content is ≤1.0%; the dried granules are sieved with 16 mesh and 80 mesh respectively Sieve, collect particles below 16 mesh and above 80 mesh; sizing particles above 16 mesh with 18 mesh sieve, collect particles below 16 mesh sieve and above 80 mesh sieve; mix the particles with magnesium stearate 10min, subpackage.

[0050] Example 2

[0051]

[0052] Preparation method: Weigh the raw and auxiliary materials in the prescription amount, crush them, sieving them for later use; mix the fumaric acid and voronolazan fumaric acid evenly to obtain the mixture ①; the mixture ①, polyprezinc, and hardened Other auxiliary materials other than magnesium fatty acid are put into the high-efficiency wet granulator and premixed for 15 minutes; into the high-efficiency wet granulator, slowly add 50% by volume ethanol solution to make soft materials; use the swing granulator to The prepared soft material is granulated with a 24-mesh sieve; the prepared wet granules are put into a hot-air circulating oven and dried at 55-65℃ until the moisture content is ≤1.0%; the dried granules are sieved with 16 mesh and 80 mesh respectively Sieve, collect particles below 16 mesh and above 80 mesh; sizing particles above 16 mesh with 18 mesh sieve, collect particles below 16 mesh sieve and above 80 mesh sieve; mix the particles with magnesium stearate 10min, subpackage.

[0053] Example 3

[0054]

[0055] Preparation method: Weigh the raw and auxiliary materials in the prescription amount, crush them, sieving them for later use; mix the fumaric acid and voronolazan fumaric acid evenly to obtain the mixture ①; the mixture ①, polyprezinc, and hardened Other auxiliary materials other than magnesium fatty acid are put into the high-efficiency wet granulator and premixed for 15 minutes; into the high-efficiency wet granulator, slowly add 50% by volume ethanol solution to make soft materials; use the swing granulator to The prepared soft material is granulated with a 24-mesh sieve; the prepared wet granules are put into a hot-air circulating oven and dried at 55-65℃ until the moisture content is ≤1.0%; the dried granules are sieved with 16 mesh and 80 mesh respectively Sieve, collect particles below 16 mesh and above 80 mesh; sizing particles above 16 mesh with 18 mesh sieve, collect particles below 16 mesh sieve and above 80 mesh sieve; mix the particles with magnesium stearate 10min, subpackage.