Pharmaceutical composition and preparation method thereof
A composition and drug technology, applied in the field of oral stable pharmaceutical composition and preparation, can solve the problems of complicated preparation process, influence drug safety, influence product quality, etc. The effect of reducing the economic burden
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[0047] Example 1
[0048]
[0049] Preparation method: Weigh the raw and auxiliary materials in the prescription amount, crush them, sieving them for later use; mix the fumaric acid and voronolazan fumaric acid evenly to obtain the mixture ①; the mixture ①, polyprezinc, and hardened Other auxiliary materials other than magnesium fatty acid are put into the high-efficiency wet granulator and premixed for 15 minutes; into the high-efficiency wet granulator, slowly add 50% by volume ethanol solution to make soft materials; use the swing granulator to The prepared soft material is granulated with a 24-mesh sieve; the prepared wet granules are put into a hot-air circulating oven and dried at 55-65℃ until the moisture content is ≤1.0%; the dried granules are sieved with 16 mesh and 80 mesh respectively Sieve, collect particles below 16 mesh and above 80 mesh; sizing particles above 16 mesh with 18 mesh sieve, collect particles below 16 mesh sieve and above 80 mesh sieve; mix the partic...
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[0050] Example 2
[0051]
[0052] Preparation method: Weigh the raw and auxiliary materials in the prescription amount, crush them, sieving them for later use; mix the fumaric acid and voronolazan fumaric acid evenly to obtain the mixture ①; the mixture ①, polyprezinc, and hardened Other auxiliary materials other than magnesium fatty acid are put into the high-efficiency wet granulator and premixed for 15 minutes; into the high-efficiency wet granulator, slowly add 50% by volume ethanol solution to make soft materials; use the swing granulator to The prepared soft material is granulated with a 24-mesh sieve; the prepared wet granules are put into a hot-air circulating oven and dried at 55-65℃ until the moisture content is ≤1.0%; the dried granules are sieved with 16 mesh and 80 mesh respectively Sieve, collect particles below 16 mesh and above 80 mesh; sizing particles above 16 mesh with 18 mesh sieve, collect particles below 16 mesh sieve and above 80 mesh sieve; mix the partic...
Example Embodiment
[0053] Example 3
[0054]
[0055] Preparation method: Weigh the raw and auxiliary materials in the prescription amount, crush them, sieving them for later use; mix the fumaric acid and voronolazan fumaric acid evenly to obtain the mixture ①; the mixture ①, polyprezinc, and hardened Other auxiliary materials other than magnesium fatty acid are put into the high-efficiency wet granulator and premixed for 15 minutes; into the high-efficiency wet granulator, slowly add 50% by volume ethanol solution to make soft materials; use the swing granulator to The prepared soft material is granulated with a 24-mesh sieve; the prepared wet granules are put into a hot-air circulating oven and dried at 55-65℃ until the moisture content is ≤1.0%; the dried granules are sieved with 16 mesh and 80 mesh respectively Sieve, collect particles below 16 mesh and above 80 mesh; sizing particles above 16 mesh with 18 mesh sieve, collect particles below 16 mesh sieve and above 80 mesh sieve; mix the partic...
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