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Dried artificial bioprosthetic valve and preparation method thereof

A biological valve and artificial technology, applied in the field of medical devices, can solve problems such as inactivation, valve compression size cannot be further reduced, easy calcification, etc., to improve service life, good physical and chemical properties and biocompatibility, and simplify the use process Effect

Active Publication Date: 2017-07-04
VENUS MEDTECH (HANGZHOU) INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a dry artificial biological valve and its preparation method, aiming at solving the problem that the existing artificial biological valve has insufficient durability, the compressed size of the valve cannot be further reduced, and the valve requires preoperative Loading, easy calcification and inactivation, harsh manufacturing and storage conditions, and poor biocompatibility

Method used

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  • Dried artificial bioprosthetic valve and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0047] Soak the porcine pericardial valve in a 5% glutaraldehyde solution for 2 days, take it out and wash it, and obtain a cross-linked and fixed artificial biological valve; then place the cross-linked and fixed artificial biological valve at a temperature of 45° C. 5.5. Soak in 20% polyethylene glycol and polyvinyl alcohol mixed solution for 7 days, take it out, and finally dry it completely at 20°C to obtain a dry artificial biological valve.

[0048] It was found through testing that the dry artificial biovalve prepared in this embodiment has excellent flexibility, and the dimension of the valve after compression is reduced by 80%, and has good biocompatibility and stable properties.

Embodiment 2

[0050] Soak the porcine pericardial valve in 4% glutaraldehyde solution for 3 days, take it out and wash it, and obtain a cross-linked and fixed artificial biological valve; then place the cross-linked and fixed artificial biological valve at a temperature of 40°C, and the pH 4.5. Soak in 30% polyethylene glycol and polyvinyl alcohol mixed solution for 5 days, take it out, and finally dry it completely at 25°C to obtain a dry artificial biological valve.

[0051] It was found through testing that the dry artificial biovalve prepared in this embodiment has excellent flexibility, and the dimension of the valve after compression is reduced by 80%, and has good biocompatibility and stable properties.

Embodiment 3

[0053] Soak the porcine pericardial valve in a 3% glutaraldehyde solution for 4 days, take it out and wash it, and obtain a cross-linked and fixed artificial biological valve; then place the cross-linked and fixed artificial biological valve at a temperature of 35° C. 4.0. Soak it in 40% polyethylene glycol solution for 3 days, take it out, and finally dry it completely at 30° C. to obtain a dry artificial biological valve.

[0054] It was found through testing that the dry artificial biovalve prepared in this embodiment has excellent flexibility, and the dimension of the valve after compression is reduced by 80%, and has good biocompatibility and stable properties.

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Abstract

The invention discloses a dried artificial bioprosthetic valve and a preparation method thereof. The preparation method includes the steps of: soaking an artificial bioprosthetic valve, which has been immobilized through crosslinking, in a polymer solution containing hydroxyl group, and after a preset time, taking the artificial bioprosthetic valve and drying the artificial bioprosthetic valve at 5-45 DEG C to prepare the dried artificial bioprosthetic valve. The dried artificial bioprosthetic valve has excellent physical and chemical performances and biocompatibility. The preparation method can increase service life of the bioprosthetic valve. The bioprosthetic valve has a flexible property even under a dried status, so that production and transportation cost of the bioprosthetic valve are reduced and use procedure of the bioprosthetic valve is simplified.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a dry artificial biological valve and a preparation method thereof. Background technique [0002] With economic development and population aging, the incidence of senile calcific aortic valve disease (CAVD) is on the rise, and it has become a cardiovascular disease second only to coronary heart disease and hypertension. A retrospective non-randomized research analysis in my country shows that the incidence of aortic valve calcification (AVC) in middle-aged and elderly patients over 50 years old is 49.38%. With the aging of the population, the incidence of calcific aortic stenosis (CAS) increases, and it is about to become the leading cause of valvular disease in my country. [0003] Aortic valve replacement (AVR) using a prosthetic valve is the gold standard in the management of all types of aortic valve disease. The application trend of transcatheter aortic valve implantation (T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/50
CPCA61L27/3625A61L27/3687A61L27/50A61L2430/20A61L2430/40
Inventor 邝大军余金城
Owner VENUS MEDTECH (HANGZHOU) INC
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