The invention discloses a dry eye disease full-automatic detecting apparatus, which comprises a probe assembly, a handle, a portable device and an analysis device, wherein the probe assembly comprises an imaging assembly, a lighting source, a camera module, a camera fixing device, a control board and a cover plate; the imaging assembly comprises an optical filter, a fixed sleeve and a conical drum; the conical drum is of an annular structure chequered with black and white; black rings are formed by conducting silk-screen printing with oil ink, and the oil ink is transmissive in infrared light and is non-transmissive in white light; one end of the handle is connected to the lower end of the probe assembly; the portable device comprises a base, a head supporting assembly, an adjusting handle rod and an adjustable workbench assembly; and the analysis device comprises an image data acquisition unit, a data detection unit and a data analysis unit. According to the detecting apparatus provided by the invention, the black annular structures on the conical drum is invisible to some infrared light while is visible to the white light, so that the demands of four imaging modes are satisfied; and it is unnecessary to detach the Placido conical drum when the detecting apparatus is used, so that a using process is simplified and the conical drum is prevented from getting lost easily.