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Application of Guanxinning composition in preparation of drugs for treating and/or preventing chronic fatigue syndrome

A technology of chronic fatigue and composition, applied in the field of medicine, can solve problems such as undetermined efficacy

Active Publication Date: 2017-07-14
SHINEWAY PHARMA GRP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Western medicine treatment of chronic fatigue syndrome is mainly symptomatic and supportive therapy, including antidepressant therapy, antiviral therapy, immunotherapy, nutritional supplements, high-dose vitamins, psychological counseling and other therapies, most of which have not yet been determined

Method used

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  • Application of Guanxinning composition in preparation of drugs for treating and/or preventing chronic fatigue syndrome
  • Application of Guanxinning composition in preparation of drugs for treating and/or preventing chronic fatigue syndrome
  • Application of Guanxinning composition in preparation of drugs for treating and/or preventing chronic fatigue syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Guanxinning composition

[0023] Danshen 1000g, Chuanxiong 1000g

[0024] Add the above two flavors, add 6L water to decoct three times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.16-1.26 (70°C), add ethanol When the content is 85%, refrigerate, filter, adjust the pH value of the filtrate to about 8.0-8.5 with 40% sodium hydroxide solution, refrigerate, filter, recover ethanol from the filtrate until it has no alcohol smell, dilute it with water for injection to about 1000ml, refrigerate, Filtrate, concentrate the filtrate to a clear paste with a relative density of 1.10-1.15 (70°C), dry, pulverize, and pass through a 100-mesh sieve to obtain the product.

Embodiment 2

[0025] Embodiment 2: Guanxinning Injection

[0026] Danshen 1000g, Chuanxiong 1000g

[0027]Add the above two flavors, add 6L water to decoct three times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.16-1.26 (70°C), add ethanol When the content is 85%, refrigerate, filter, adjust the pH value of the filtrate to about 8.0-8.5 with 40% sodium hydroxide solution, refrigerate, filter, recover ethanol from the filtrate until it has no alcohol smell, dilute it with water for injection to about 1000ml, refrigerate, Filter, concentrate the filtrate to a clear paste with a relative density of 1.10-1.15 (70°C), adjust the pH value to 2-3 with hydrochloric acid solution, refrigerate, filter, and adjust the pH value of the filtrate to 6.8-7.2 with 10% sodium hydroxide solution, Heat and boil for 30 minutes, add appropriate amount of activated carbon, coo...

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Abstract

The invention relates to the medicine field, and specifically relates to an application of a Guanxinning composition in the preparation of drugs for treating and / or preventing chronic fatigue syndrome. The Guanxinning composition is composed of red sage root and ligusticum wallichii according to a ratio of 1:1 and has the functions of promoting blood circulation to remove blood stasis, freeing the collateral vessels, and nourishing heart. At present, the Guanxinning composition is made into a Guanxinning injection. The Guanxinning water injection, which is developed in 1970s, has been on sale for more than thirty years, is a common traditional Chinese medicine injection for treating cardio-cerebrovascular diseases in clinic, and can improve the coronary circulation, prevent blood clotting, prominently increase the coronary blood-flow volume, improve myocardial blood supply, prevent and reduce the formation of thrombus, and reduce the range of embolism. The Guanxinning composition is mainly used to treat coronary heart disease and angina.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Guanxinning composition in the preparation of medicines for treating and / or preventing chronic fatigue syndrome. Background technique [0002] The Guanxinning composition is composed of two traditional Chinese medicines, Danshen and Chuanxiong, and has the functions of promoting blood circulation and removing blood stasis, dredging the meridians and nourishing the heart. The chemical components in Chuanxiong mainly include alkaloids such as ligustrazine and phenolic substances such as ferulic acid, chrysophanol and ligustrazine. The pharmacological effects of Rhizoma Chuanxiong are mainly through the antagonism of calcium and scavenging free radicals, and it has obvious protective and improvement effects on the damage of ischemic tissues and organs. / PGI2 and other effects and has antithrombotic effect. Guanxinning injection is a traditional Chinese medici...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P39/00
CPCA61K36/236A61K36/537A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 关秀伟张纲李志刚张志伟赵淑欣巴晓雨许桂玲
Owner SHINEWAY PHARMA GRP LTD