Crystallizer controlling crystal granularity through ultrasonic waves and crystallization method

A technology of crystallizer and ultrasonic wave, which is applied in the field of chemical industry, can solve the problems of increasing the operation process, destroying the crystal surface and crystal form by a large number of impurities, reducing product quality, etc., achieving high grinding efficiency, improving product quality, and easy installation. Effect

Active Publication Date: 2017-07-25
天津晶润锐拓科技发展有限公司
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  • Application Information

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Problems solved by technology

This method not only increases the operation process, but also makes it easier to introduce impurities. At the same time, mechanical grinding is not only easy to produce a large number of broken crystals, but also destroys the surface and crystal form of the crystals, reducing product quality.

Method used

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  • Crystallizer controlling crystal granularity through ultrasonic waves and crystallization method
  • Crystallizer controlling crystal granularity through ultrasonic waves and crystallization method
  • Crystallizer controlling crystal granularity through ultrasonic waves and crystallization method

Examples

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Embodiment 1

[0032] The whole crystallizer structure is as figure 1 As shown, wherein the volume of the crystallization mother liquid container is 120 liters, and the bottom of the settling tank is provided with eight 60W ultrasonic generators. In the crystallization mother liquid container, the roxithromycin crystal is cooled and crystallized by using the mixed liquid of ethanol and water as a solvent. 25 kilograms of roxithromycin were dissolved in a mixture of 50 kilograms of ethanol and 50 kilograms of water, and the intermittent elution crystallization experiment was carried out at a cooling rate of 0.4°C / min at a temperature of 75°C.

[0033] The crystal nuclei were naturally precipitated at 55°C. After 30 minutes of heat preservation, the temperature was lowered at a rate of 0.4°C / min. At the same time, the ultrasonic generator was turned on, and the circulation rate of the crystal slurry was 3.5L / min. After cooling down to 0°C, turn off the ultrasonic generator, but continue to ke...

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Abstract

The invention discloses a crystallizer controlling crystal granularity through ultrasonic waves and a crystallization method. The crystallizer comprises a crystallization mother liquid container (4), an outer circulating pipe (5) is arranged outside the crystallization mother liquid container (4), a crystal blade pump (3) and a settling tank (6) are arranged on the outer circulating pipe (5), an ultrasonic generator (1) is arranged at the bottom of the settling tank (6), the settling tank (6) is provided with a bypass backflow pipe (7) in fluid communication with the same, an outlet end of the backflow pipe (7) is in fluid communication with the fluid of the outer circulating pipe 95), and a fine crystal eliminator (2) is arranged on the backflow pipe (7). The crystallizer effectively improves quality of crystal products; by grinding high-granularity crystals through the ultrasonic waves, the problem that the crystal products are high in granularity in the crystallization process can be solved while control on granularity and grain size distribution of the crystal products is realized, and product quality is improved.

Description

technical field [0001] The invention belongs to the field of chemical application technology, and in particular relates to a crystallizer and a crystallization method for controlling crystal particle size through ultrasonic waves. Background technique [0002] Modern industrial crystallization technology and equipment are the common core technology for the preparation of high-end biomedical products, the core technology for finishing processing with green and intelligent features, and the core technology for realizing the upgrading of biomedicine from low-end crude products to high-end functional products. The overall improvement of the competitiveness of the biomedical industry is a key common core technology that has a driving and overall impact. Strengthening research and development in this field has become a strategic commanding height that must be seized. [0003] Crystal particle size and particle size distribution are one of the most important indicators of crystal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D9/02
CPCB01D9/0063B01D9/0081
Inventor 郭志超毛国柱韩文祥郭炽杨松王宝冬王欣池
Owner 天津晶润锐拓科技发展有限公司
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