Pharmaceutical composition for use in anticoagulation
A composition and anticoagulant technology, applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve problems such as unknown mechanism
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Embodiment 1
[0053] Example 1: Time Variation (aPTT)
[0054] To explore the anticoagulant efficacy of intrinsic pathways in the coagulation system of IA-treated mice, aPTT was measured at different treatment times. Mice (n=6) were intraperitoneally injected with 1 mL, 1000 ppm (0.05 mL / kg) of IA, and blood was collected 1 hour, 2 hours, 3 hours, and 24 hours after IA injection. A blank sample (vehicle) was injected into 10 mice (n=10), which were used as a control group. Then, aPTT was measured for each group. The measurement results are shown in Table 1-1 and Figure 2A . Figure 2A It is the schema of Table 1-1.
[0055] Table 1-1: aPTT of IA-treated mice at different treatment times
[0056] Processing time (hours) 0 1 2 3 24 N 10 6 6 6 6 aPTT average (seconds) 26.3 30.8 32.0 33.7 34.8 S.D. 3.6 1.5 3.5 2.1 4.1 *p-value --- 0.004 0.008 <0.001
0.001
[0057] *Data are compared with untreated group (treatment time 0 hours)....
Embodiment 2
[0059] Example 2: Dose Effect (aPTT)
[0060] To explore the anticoagulant efficacy of intrinsic pathways in the coagulation system of IA-treated mice, aPTT was also measured at different IA doses. ImL of various IA doses (1 ppm, 10 ppm, 100 ppm, 1,000 ppm) were injected intraperitoneally into different groups of mice (n=6). Plasma was separated after 3 hours. Blank samples were injected into 10 mice (n=10), which were used as a control group. Then, aPTT was measured for each group. The measurement results are shown in Table 1-2 and Figure 2B . Figure 2B It is the schema of Table 1-2.
[0061] Table 1-2: aPTT of IA-treated mice at different doses
[0062] Injection dose (ppm) 0 1 10 100 1000 N 10 6 6 6 6 aPTT average (seconds) 26.3 33.0 33.0 33.4 33.7 S.D. 3.6 4.4 4.5 2.3 2.1 *p-value --- 0.005 0.006 <0.001
0.001
[0063] Samples were taken 3 hours after IA intraperitoneal injection.
[0064] *The data are c...
Embodiment 3
[0066] Example 3: Time Variation (PT)
[0067] Furthermore, to explore the anticoagulant efficacy of the extrinsic pathway in the coagulation system of IA-treated mice, PT was measured at different treatment times. Mice in different groups (n=6) were injected intraperitoneally with 1 mL and 1000 ppm (0.05 mL / kg) of IA, respectively, and blood was collected at 1 hour, 2 hours, 3 hours, and 24 hours after IA injection. Blank samples were injected into 10 mice (n=10), which were used as a control group. Then, measure the PT for each group. The measurement results are shown in Table 2-1 and Figure 3A . Figure 3A It is the schema of Table 2-1.
[0068] Table 2-1: PT of mice treated with IA at different treatment times
[0069] Processing time (hours) 0 1 2 3 24 N 10 6 6 6 6 PT average (seconds) 11.1 11.6 12.2 12.6 13.2 S.D. 0.7 1.0 1.1 1.2 0.5 *p-value --- 0.189 0.029 0.006 <0.001
[0070] *Data are compared with u...
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