Photon crystal gel material for detecting glucose and glucose detection method

A photonic crystal and gel material technology, applied in the field of glucose detection, can solve the problems of low selectivity, cumbersome detection steps, and long response time

Active Publication Date: 2017-08-18
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the current non-invasive non-enzymatic glucose detection methods still have problems such as low selectivity, insufficient sensitivity, long response time or cumbersome detection steps.

Method used

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  • Photon crystal gel material for detecting glucose and glucose detection method
  • Photon crystal gel material for detecting glucose and glucose detection method
  • Photon crystal gel material for detecting glucose and glucose detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] 1) Preparation of three-dimensional photonic crystals

[0088] A large amount of activated carbon is added to methyl methacrylate for pretreatment to remove the polymerization inhibitor in order to carry out the reaction. Take 6ml of methyl methacrylate and 144ml of H 2 O, added to a 250mL four-neck flask, mechanically stirred at a speed of 300rpm, and then fed into N 2 The temperature of the reaction solution was raised to 80° C. under a favorable environment, and 0.3 g of potassium persulfate initiator was quickly added to initiate reaction polymerization. Keep the reaction temperature constant under the condition of condensing and reflux, and react for 45 minutes to obtain white polymethyl methacrylate (PMMA) microsphere emulsion. The emulsion was repeatedly centrifuged and washed 4 times with deionized water to obtain PMMA microspheres with a particle diameter of about 180 nm for subsequent use.

[0089] Concentrated sulfuric acid and hydrogen peroxide were prepa...

Embodiment 2

[0112] 1) Preparation of two-dimensional photonic crystal

[0113] Use basic alumina to filter a sufficient amount of styrene to remove the polymerization inhibitor, and then add 25 mL of pretreated styrene solution, 1 g of hydroxyethyl methacrylate (HEMA) solution and 100 mL of deionized water In a 250mL four-neck flask equipped with a mechanical stirring rod, a thermometer and a condenser tube, adjust the mechanical stirring speed to 350rpm, and then add N 2 The mixed solution passed into the flask was used to remove the oxygen therein. After bubbling nitrogen gas for 1 h, the temperature of the above solution was raised to 70° C., and 3 mL of potassium persulfate (0.2 mmol) solution was added as an initiator to initiate the reaction. The reaction is maintained at temperature, N 2 Continued for 24h under the condition of constant atmosphere and stirring speed. After the reaction, a white PS microsphere emulsion was obtained. The obtained microspheres were centrifuged and...

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Abstract

The invention provides a photon crystal gel material for detecting glucose, which comprises polyacrylamide-acrylic acid gel and a photon crystal embedded in the gel, wherein the gel is directly or indirectly chemically grafted with phenylboronic acid groups, and the photon crystal is two-dimensional photon crystal or three-dimensional photon crystal. The invention also provides a glucose detection method based on the photon crystal gel material, and the color information displayed after the photon crystal gel material detects a glucose solution is converted into glucose concentration information. The glucose detection method provided by the invention can qualitatively or quantitatively detect glucose concentration with high selectivity, sensitivity, convenience and visualization, and provide a novel non-invasive detection method for urine glucose monitoring of diabetics.

Description

technical field [0001] The invention relates to the technical field of glucose detection, in particular to a photonic crystal gel material for detecting glucose, and a glucose detection method and device. Background technique [0002] In recent years, diabetes has increasingly become one of the most serious factors affecting human health worldwide. This chronic disease not only causes great suffering to patients, but also causes complications such as stroke and cardiovascular disease to patients. cause some damages. In order to control the harm caused by this disease, real-time and accurate monitoring of sugar content is very necessary. However, at this stage in my country, blood glucose testing methods commonly used in clinics and households all require blood collection, which not only causes pain and inconvenience to patients, but also may cause wound infection and bring secondary harm to patients. [0003] In recent years, the development direction of blood glucose dete...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/56C08F222/38C08F220/06C08F120/14C08F8/42C08F212/08C08F220/28C08J3/075C08L33/26C08L33/12C08L25/14G01N21/25
CPCC08F8/42C08F120/14C08F212/08C08F220/56C08J3/075C08J2333/26C08J2425/14C08J2433/12C08L33/26G01N21/25C08F222/385C08F220/06C08L33/12C08L25/14C08F220/281
Inventor 孟子晖闫泽群薛敏蓝云鹤王树山
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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