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Use of chimonanthus plant anti-mycobacterium tuberculosis

An anti-tuberculosis and plant technology, applied in the field of medicine, can solve the problems that there are no research reports on the anti-tuberculosis bacteria of willow-leaved wintersweet, Zhejiang wintersweet and mountain wintersweet

Active Publication Date: 2017-09-08
浙江华润三九众益制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Searching pharmacological research information, there is no research report on the anti-tuberculosis bacteria of willow-leaf wintersweet, Zhejiang wintersweet and mountain wintersweet

Method used

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  • Use of chimonanthus plant anti-mycobacterium tuberculosis
  • Use of chimonanthus plant anti-mycobacterium tuberculosis
  • Use of chimonanthus plant anti-mycobacterium tuberculosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-11

[0105] Water extraction: Take the crushed medicinal materials, put them into a round bottom flask, and add water twice to reflux for extraction. Add 10-16 times of water for the first time, filter after 1 hour of extraction, add 8-12 times of water for the second time, extract for 1 hour, and combine the two filtrates. Concentrate on a rotary evaporator or concentrate on a water bath, water bath at 75°C, rotation speed 80rpm, concentrate to a specific gravity of 1.18-1.22, pour it into a stainless steel plate, place it in a vacuum drying oven at 65°C, dry it in a vacuum and crush it.

[0106] Alcohol extraction: Take the crushed medicinal materials, put them into a round bottom flask, and add ethanol twice for reflux extraction. Add 10 times of ethanol for the first time, filter after 1 hour of extraction, add 8 times of ethanol for the second time, extract for 1 hour, and combine the two filtrates. Concentrate on a rotary evaporator, water bath at 65°C, rotating speed at 80r...

Embodiment 12

[0111] Embodiment 12 (supercritical does not add entrainer)

[0112] Weigh 6.4kgLY and place it in a 24L extraction kettle. Weigh 3.2kg of 95% ethanol, place it in the storage tank of the auxiliary pump, turn on the auxiliary pump (R=9.1r / min), and finish adding the entrainer within 60 minutes. The pressures of extraction kettle II, separation kettle I, separation kettle II, and separation kettle III are 20.7MPa, 8.5MPa, 5MPa, and 5MPa respectively, and the temperatures are 45°C, 55°C, 40°C, and 40°C respectively, and the speed of the main pump R= 30.5r / min, carbon dioxide flow rate is 220-240L / h. After extraction for 135 min, after post-treatment, 1.3 g of product was collected in separation tank I, and 200.4 g of product was collected in separation tank II, numbered LYLJ-2(2-6), with a total yield of 3.15%.

Embodiment 13

[0113] Embodiment 13 (supercritical does not add entrainer)

[0114] Weigh 6.5kgLY and place it in a 24L extraction kettle. After the pressure has stabilized, the extraction begins. The pressures of extraction kettle II, separation kettle I, separation kettle II, and separation kettle III are 20MPa, 8MPa, 5MPa, and 5MPa respectively, and the temperatures are 45°C, 55°C, 40°C, and 40°C respectively, and the speed of the main pump is R=30.5r / min, the flow rate of carbon dioxide was 210-230L / h, the extraction was 103min, and after post-treatment, 101g of reddish-brown oil was collected, with a yield of 2.05%, code number LYLW(2-2).

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Abstract

The invention discloses a use of chimonanthus plant anti-mycobacterium tuberculosis, and particularly relates to application of a chimonanthus plant and an extractive thereof for preparing pharmaceutical for anti-mycobacterium tuberculosis and diseases caused by the anti-mycobacterium tuberculosis. The chimonanthus plant comprises willow-pattern calyx canthus, Zhejiang calyx canthus and mountain calyx canthus. The extractive comprises a water extractive, an alcohol extractive, a steam distillation extractive and a supercritical extractive.

Description

technical field [0001] The invention specifically relates to the application of wintersweet plants and their extracts in the preparation of medicines for preventing / treating related diseases caused by Mycobacterium tuberculosis. The said wintersweet plants include willow-leaved wintersweet, Zhejiang wintersweet and mountain wintersweet, belonging to the field of medical technology. [0002] Background technique: [0003] Wintersweet (Chimonanthus salicifolius S.Y.Hu), Zhejiang wintersweet (Chimonanthuszhejiangensis M.C.Liu) or mountain wintersweet (Chimonanthus nitens Oliv.) are traditional medicines of the She people, and their dried leaves have been taken as herbal tea since the Northern Song Dynasty. , has been used for the treatment and prevention of colds for nearly a thousand years. Modern research has progressed again. Among them, the granule preparation prepared from the extract of wintersweet has a good effect on treating / preventing colds and has been sold in the mar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P31/06
CPCA61K36/185A61K2236/33A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51
Inventor 王子厚张天宇马领弟陈昌红
Owner 浙江华润三九众益制药有限公司
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