Nano calcium phosphate bone cement and preparation method thereof

A technology of calcium phosphate bone cement and nano-calcium phosphate, which is applied in the fields of pharmaceutical formula, medical science, tissue regeneration, etc., can solve the problems of poor load bearing capacity, slow bone formation speed, slow solidification speed, etc., and achieve enhanced strength, industrial Simple, osteogenic activity-enhancing effect

Active Publication Date: 2017-09-08
AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has disadvantages, such as slow solidification speed, low strength, poor mechanical properties, high brittleness and poor load bearing capacity, and slow bone formation speed, which greatly limits its application.

Method used

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  • Nano calcium phosphate bone cement and preparation method thereof
  • Nano calcium phosphate bone cement and preparation method thereof
  • Nano calcium phosphate bone cement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 (2#)

[0025] The solid phase of the nano-bone cement in this example is a mixture of tetracalcium phosphate and anhydrous calcium hydrogen phosphate with a molar ratio of 1:3. γ ferric oxide colloidal solution (RosnerMH, Auerbach M. Ferumoxytol for the treatment of iron deficiency. Expert RevHematol. 2011 Aug;4(4):399-406.).

[0026] Wherein the preparation method of tetracalcium phosphate is as follows: Synthesize tetracalcium phosphate powder with solid-state reaction method, the anhydrous calcium hydrogen phosphate of equimolar amount and calcium carbonate calcined in 1500 ℃ furnace for 6 hours, heating rate 25 ℃ / min, after calcining Cool and grind in a ball mill to an average particle size of 5 μm. The average particle size of anhydrous calcium phosphate is 1 μm.

[0027] The nanometer material is a colloidal solution of nanometer gamma-ferric oxide wrapped by PSC, with an average particle size of 9nm, and it is used as a bone cement solidification solu...

Embodiment 2

[0031] Example 2 (3#)

[0032] The preparation steps of the nano-bone cement in this example are the same as in Example 1, the difference is that the nano-material is a colloidal solution of nano-α ferric oxide wrapped in DMSA, and the concentration is 2.55 mg / mL. The specific examples are as follows: This example The nano-bone cement material is composed of the following powder-liquid components: 2 parts of a mixture of tetracalcium phosphate and anhydrous calcium hydrogen phosphate with a molar ratio of 1:3, and 1 part of DMSA-wrapped nano-α ferric oxide colloidal solution (Sun J, Su Y, Wang C, Gu N. The investigation of frequency response for the magnetic nanoparticulate assembly induced by time-varied magnetic field. Nanoscale Res Lett. 2011 Jul 14;6:453.).

[0033] Wherein the preparation method of tetracalcium phosphate is as follows: Synthesize tetracalcium phosphate powder with solid-state reaction method, the anhydrous calcium hydrogen phosphate of equimolar amount an...

Embodiment 3

[0038] Embodiment 3 (4#)

[0039] The preparation steps of the nano-bone cement in this example are the same as in Example 1, the difference is that the nano-material is a nano-gold colloid solution wrapped in citric acid, and the concentration is 0.5mg / mL. The content of the specific example is: the nano-bone of this example The cement material is composed of the following powder-liquid components: 2 parts of a mixture of tetracalcium phosphate and anhydrous calcium hydrogen phosphate with a molar ratio of 1:3, and 1 part of citric acid-coated nano-gold colloid solution (Wang P, Sun J, Lou Z, Fan F, Hu K, Sun Y, Gu N. Assembly-Induced Thermogenesis of Gold Nanoparticles in the Presence of Alternating Magnetic Field for Controllable Drug Release of Hydrogel. Adv Mater. 2016Dec;28(48):10801-10808.).

[0040] Wherein the preparation method of tetracalcium phosphate is as follows: Synthesize tetracalcium phosphate powder with solid-state reaction method, the anhydrous calcium hyd...

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Abstract

The invention relates to nano calcium phosphate bone cement and a preparation method thereof. The nano calcium phosphate bone cement is prepared by the steps of adding a water soluble nanomaterial into calcium phosphate bone cement; and uniformly mixing the mixture and self-curing the mixture to obtain the nano calcium phosphate bone cement. The nano bone cement is prepared by mixing a metal nanomaterial which is good in biocompatibility with bone cement matrix powder. The material not only has a good mechanical property, but also has the enhanced osteogenic activity. The performance of the nano bone cement can be adjusted by adjusting the type and quantity of the nanomaterial, for example, the bone cement is endowed with a magnetic property by adding a magnetic nanomaterial, and the strength of the bone cement is enhanced by increasing the additive amount of the nanomaterial in a certain range. The preparation method of the nano bone cement provided by the invention is simple in process and high in operability, can better meet the clinical use demand and has promotional value.

Description

technical field [0001] The invention belongs to the technical field of biomedical inorganic materials, and in particular relates to a nano calcium phosphate bone cement and a preparation method thereof. Background technique [0002] Oral and maxillofacial congenital malformations, trauma, tumors, inflammation, etc. cause jaw defects not only cause facial deformities, but also cause oral dysfunction such as speech, chewing, breathing, etc., and bring many adverse effects on patients' physiology and psychology. Therefore, jaw defect has always been the focus and difficulty of clinical treatment. Bone grafting is the most commonly used treatment method. Bone grafting materials include autologous bone, allogeneic bone, xenograft bone and artificial bone. Among them, autogenous bone is considered to be the "gold standard" for the treatment of bone defects. However, the sources of autologous bone and allogeneic bone are limited, and xenograft bone has strong antigenicity, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/04A61L27/02A61L27/54A61L27/50A61L27/58
CPCA61L27/025A61L27/047A61L27/425A61L27/50A61L27/54A61L27/58A61L2300/102A61L2300/604A61L2400/12A61L2430/02
Inventor 夏阳章非敏秦天牧马俊青陈慧敏
Owner AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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