50results about How to "Meet the needs of clinical use" patented technology

The embodiment of the invention provides a medical data processing method, a medical data processing device, a computer readable medium and an electronic device. The method includes the steps of determining a disease recommended treatment scheme according to obtained illness state parameters of a current patient and medical experience, conducting matching in a medical history of historical patients to determine target medical history information according to the illness state parameters, and using the recommended treatment scheme and the target medical history information as medical decision making information of the current patient. Through the medical decision making information of the current patient determined by the technical scheme, the diagnosis and treatment scheme of the current patient is determined; meanwhile, considering the two factors of medical experience and clinical medical history, the management and analysis result practicability based on medical data can be easily improved, and then the obtained medical decision making information for disease treatment meets clinical use requirements.

The invention discloses a magnetic resonance diffusion imaging method for integration and reconstruction based on a Gaussian diffusion model acting as an instance. The method comprises the steps that signal acquisition is performed on a tested target based on multilayer simultaneously excited preset sequences; phase estimation is performed on the acquired under-sampled signals through a parallel imaging technology; the Gaussian diffusion model is established through the estimated phase, the acquired under-sampled signals and a reference image without diffusion weight; the under-sampled signals of all the directions are integrated according to the Gaussian diffusion model, and a target equation is established; the target equation is iteratively solved by using a nonlinear conjugate gradient algorithm so as to obtain a diffusion tensor parameter; and a diffusion coefficient and a diffusion weight image are calculated according to the diffusion tensor parameter. Therefore, high acceleration acquisition of magnetic resonance diffusion tensor imaging can be realized so that the acquisition time can be effectively reduced, the diffusion tensor parameter can be accurately estimated to obtain the diffusion image of high signal-to-noise ratio and high resolution, and the requirement of clinical application can be met.

The invention provides a method for separating umbilical cord mesenchymal stem cell simply and effectively, which comprises the steps of separating umbilical cord mesenchymal stem cell with cannulas, digesting umbilical cord mesenchymal stem cell with trypLETM and cultivating umbilical cord mesenchymal stem cell with a serum-free medium. According to the method, an umbilical cord mesenchymal stem cell from a mother's body completely can be obtained relatively fast, and damage on the cell is relatively low; tests show that according to the method, mesenchymal stem cell can be protected to the most extent, the motility rate as well as the activity is relatively high, and adipogenesis and osteogenic induced differentiation can be carried out effectively.

The invention discloses a synthesis method of cyclic pentapeptide. According to the synthesis method, the 'solid-liquid combined production' strategy is adopted, a proper condensation agent is used for a condensation reaction, linear pentapeptides are prepared respectively through a proper process, the cyclization site is located between N-methyl-leucine and leucine, and the efficiency of linear peptide preparation is effectively improved.The proper condensation agent is used for the condensation reaction, racemization in amido bond formation can be effectively reduced, therefore, the purity of a target product can be effectively improved, reaching 99% or above, the requirements of biological activity tests and clinical application can be fully met, and the synthesis method of cyclic pentapeptide has high medical value. The cyclization agent PyBOP is used for a cyclization reaction, the cyclization yield can be effectively increased and reach up to 84.2%.The synthesis method does not require complex purification by column chromatography, redundant amino acids can be simply washed away, the synthesis process is simple, the cost of raw materials is low, reaction conditions are mild, the purity is high, industrialization is easy, and the synthesis method has broad market prospects.

The invention discloses a binocular vision acupoint positioning indicator and a working method thereof. The positioning indicator includes a support frame, cameras, an infrared transmitter, a computerand a calibration board, the two cameras and the infrared transmitter are placed on the support frame and both are installed on the support frame, and the cameras are connected with the computer through a data line; the support frame stretches over an examination couch, and the calibration board is installed on the examination couch; the cameras are installed on the support frame through a universal hinge with a driving device, and the infrared transmitter is installed on the support frame through the universal hinge with the driving device. According to the binocular vision acupoint positioning indicator and the working method thereof, images taken by the two cameras from different positions are collected, which is a binocular vision technology, not only can three-dimensional informationof an object be recovered, but also the acupoint positioning indicator has the function of accurate positioning, the accuracy is high, the practicability is high, and the binocular vision technologyis combined with an individualeum length acupoint positioning method provided by a medical book, so that the problem of doctors' acupoint positioning inaccuracy is effectively solved.

The invention relates to the manufacturing of a nail, in medical equipment industry. It twists the linear material for making nails tightly to the symmetrical slant mold, intersecting the linear material to form the nail with each having two feet, each having a symmetrical slant surface. In this way, the binding machine used nails is realized mass production. With natural occurrence of two slant surfaces of the nail feet, symmetrical in location, consistent in shape, high in yield rate, it meets clinical requirement. It is simple, high in efficiency, low in cost, good in implementation effect, and with advances in this field.

The invention provides a preparation method of a placenta source matrix mesenchymal stem cell. The preparation method comprises the following steps: (1) separating the placenta source matrix mesenchymal stem cell; (2) cultivating the placenta source matrix mesenchymal stem cell, wherein a trypLE<TM> enzyme solution is utilized to process a placenta tissue in two steps in the step (1), and a serum-free medium is utilized in the step (2). By adopting the method provided by the invention, the placenta source matrix mesenchymal stem cell is a complete matrix source by short tandem repeat sequence (STR) atlas analysis, and is qualified by chromosome karyotype examination, pathogenic microorganism examination of bacteria, funguses and viruses, cell purity identification and cell biology function identification. Therefore, the placenta source matrix mesenchymal stem cell obtained by the method provided by the invention does not contain foreign protein, can meet the requirements of clinical use, is especially suitable for use by mothers, and also provides a technical support for building an excellent placenta source matrix mesenchymal stem cell bank.

The invention relates to an implanted completely bioresorbable blood vessel polymer support which comprises five or more annular wave-shaped supporting rods and connecting rods connected between the supporting rods at intervals. The supporting rods of the support are formed by alternately connecting quasi-arc-shaped waves and quasi-m-shaped waves, wherein the quasi-arc-shaped waves and the quasi-m-shaped waves are formed by connecting two sets of forward s and inverted s respectively, and every two adjacent supporting rods are connected by connecting the tops of the quasi-arc-shaped waves and the bottoms of the quasi-m-shaped waves through the corresponding connecting rod. The net pattern form of the polymer support is carved on a thin wall pipe through lasers. According to the scheme, the contradiction among the radial supporting force, the wall thickness and flexibility of the polymer support is resolved, the radial supporting force, the wall thickness and flexibility are considered at the same time, good passage capacity is achieved, enough mechanical supporting can be given to a lesion segment within the specific time of injury healing, the support is gradually absorbed by the body after injury healing, endothelialization is good, and the stenosis rate of the support and the risk of the support in later stent thrombosis are reduced effectively.

The invention relates to nano calcium phosphate bone cement and a preparation method thereof. The nano calcium phosphate bone cement is prepared by the steps of adding a water soluble nanomaterial into calcium phosphate bone cement; and uniformly mixing the mixture and self-curing the mixture to obtain the nano calcium phosphate bone cement. The nano bone cement is prepared by mixing a metal nanomaterial which is good in biocompatibility with bone cement matrix powder. The material not only has a good mechanical property, but also has the enhanced osteogenic activity. The performance of the nano bone cement can be adjusted by adjusting the type and quantity of the nanomaterial, for example, the bone cement is endowed with a magnetic property by adding a magnetic nanomaterial, and the strength of the bone cement is enhanced by increasing the additive amount of the nanomaterial in a certain range. The preparation method of the nano bone cement provided by the invention is simple in process and high in operability, can better meet the clinical use demand and has promotional value.

The invention discloses a method and a kit for rapidly detecting an immunosuppressive agent in whole blood and application of the kit. The method for rapidly detecting the immunosuppressants in the whole blood comprises the following steps: carrying out sample treatment on a whole blood sample to be detected, and then carrying out liquid chromatography-tandem mass spectrometry detection, so that five immunosuppressants are detected at the same time; the sample treatment comprises the following steps: adding a precipitant 1 into a whole blood sample to be detected to carry out first precipitation treatment, adding a precipitant 2 to carry out second precipitation treatment, and centrifuging to obtain a supernatant; wherein the precipitant 1 is a zinc sulfate solution, the precipitant 2 is amethanol acetonitrile solution containing known amounts of internal standard substances, and the internal standard substances comprise a cyclosporine A isotope internal standard substance, an everolimus isotope internal standard substance, a sirolimus isotope internal standard substance and a mycophenolic acid isotope internal standard substance. According to the method and the kit disclosed by the invention, five immunosuppressants which are commonly involved and used can be detected at one time by only needing a small amount of whole blood samples, the method is simple and easy to operate,and a reference basis is provided for formulating an individualized dosing scheme.

The invention provides a drainage liquid monitoring management system which comprises an outer drainage pipe, a dropping bottle, a treatment system and a photoelectric detecting system. The drainage pipe is connected with the top end of the dropping bottle, the photoelectric detecting system is electrically connected with the treatment system, and the photoelectric detecting system comprises a light source and a photoelectric sensing module which are oppositely arranged on two sides of the dropping bottle. The light source is a line light source, the photoelectric sensing module is a linear array photoelectric sensing module or an area array photoelectric sensing module formed by dot array photoelectric sensing module parts, and a response wave band range of the photoelectric sensing module covers a wave band range of the light source. The drainage liquid monitoring management system can relieve the workload of medical staff and can simultaneously and timely monitor drainage liquid volume, accumulative drainage volume, drainage liquid color and turbidity.

The invention discloses compound quinhydrone liposome and a preparation method thereof. The compound quinhydrone liposome comprises drug active components such as retinoic acid and quinhydrone, and accessory materials. The compound quinhydrone liposome comprises, by weight, 1.0-6.0% of quinhydrone, 0.1-1.0% of retinoic acid, 70.0-85.0% of phosphatide, 15.0-25.0% of cholesterol and 0.1-1.0% of sodium bisulfate. The preparation method comprises the following steps of adding waterless ethanol and chloroform into quinhydrone, retinoic acid and sodium hydrogen sulfate for full dissolution, mixing the obtained solution and a waterless ethanol-chloroform solution of phosphatide and cholesterol to obtain a uniform mixed solution, carrying out vacuum pressure reduction, removing the organic solvent so that a uniform dry film is obtained, adding a preheated 0.2M phosphoric acid buffer into the uniform dry film, carrying out rotary evaporation washing on the film and carrying out ultrasonic treatment to obtain the compound quinhydrone liposome. The compound quinhydrone liposome has a stable structure, oxidation resistance and no irritation, has clear effects of treating chloasma, freckle and hyperpigmentation after inflammation, can promote skin targeting penetration, improves curative effects and has good effects.

The invention discloses a composition and a kit for detecting EGFR gene deletion mutation, and a detection method. The composition comprises a mutant-type detection composition and / or a wild-type detection composition, wherein the mutant-type detection composition comprises an upstream primer F1, an upstream primer F1-1, a hydrolysis probe P1 and a downstream primer; the wild-type detection composition comprises an upstream primer F2, an upstream primer F2-1, a hydrolysis probe P2 and a downstream primer, wherein each of the upstream primer F1 and the upstream primer F2 comprises a non-matching region and a matching region; and the matching regions of the upstream primers F1 and F2 are specifically bound to the to-be-detected sequence regions respectively. The unmatched regions of the upstream primers F1 and F2 have the same sequences of the upstream primers and hydrolysis probes for corresponding detection. Compared with the prior art, the composition has the advantages that the sensitivity and the height specificity are remarkably improved, the primers and the test cost are greatly reduced, and the application value is extremely high.

The invention discloses a high-sensitivity nucleic acid sequence detection composition and a detection method. The composition comprises a first upstream primer, a second upstream primer, a probe anda downstream primer, wherein the first upstream primer is sequentially composed of the following two parts from a 5' end to a 3' end of (1) a non-matching area, wherein complementary pairing does notoccur with a target nucleic acid sequence; the sequence of the non-matching area from the 5' end to the 3' end comprises the same sequence as the second upstream primer, and the same sequence as the probe; and (2) a matching area, wherein complementary pairing occurs with the target nucleic acid sequence. Compared with the prior art, the primer probe composition provided by the invention has the remarkable advantages of high sensitivity, high specificity, low cost and the like, is suitable for nucleic acid detection of various sample types, and has extremely high application value.

The invention discloses a transdermal drug delivery system of high-solubility ibuprofen or a structural analog of the ibuprofen. The transdermal drug delivery system comprises a polymer matrix layer,and the polymer matrix layer contain active ingredients, pressure sensitive adhesive and compounds for regulating and controlling the solubility of the active ingredients, wherein the compounds comprise first polymer hyrdroxypropyl methylcellulose acetate succinate (HPMCAS) and a second polymer compound; and the second polymer compound comprises pharmaceutically acceptable fat-soluble polymers and / or amphiphilic polymers. According to the transdermal drug delivery system, by selecting the types, the using amount and the proportion of the first polymer HPMCAS and the second polymer compound, the solubility, the releasing speed and the transdermal diffusion rate of the ibuprofen or the structural analog of the ibuprofen in the transdermal drug delivery system can be selectively regulated andcontrolled; through joint action of the HPMCAS and the second polymer compound, the soluble state of the ibuprofen or the structural analog of the ibuprofen in a polymer matrix can be maintained, crystallization of the ibuprofen or the structural analog of the ibuprofen can be inhibited, and the ibuprofen or the structural analog of the ibuprofen can be preserved stably for a long term; and a production process is easy, convenient, controllable and economical.

The invention discloses a hydrophilic anti-fog nano coating for an endoscope and a coating. The hydrophilic anti-fog nano coating comprises the following components in parts by weight: 1-10 parts of plant polyphenol, 0.1-2 parts of metal ions, 0.1-0.5 part of biomass molecules, 10-20 parts of an auxiliary agent and 250 parts of a solvent, the coating is coated on the surface of a base material, and the required coating can be obtained after drying. Plant polyphenol and metal ions are combined to form a plant polyphenol-metal nano complex, the plant polyphenol-metal nano complex and biomass molecules form a hydrophilic nano film on the surface of the laparoscope, and the hydrophilicity of a lens surface interface is enhanced synergistically; the formula disclosed by the invention has high biocompatibility, does not cause clinical side reaction when being in contact with tissues, and can meet the requirements of clinical use.

The invention discloses an implant activation method and an activated implant and belongs to the field of medical products. The method comprises the step of irradiating a to-be-activated implant underan excimer light source for activation treatment, wherein the excimer light source provides 148-196 nm vacuum ultraviolet with 6.3-8.4 eV photon energy for the to-be-activated implant. By use of theactivation method, a hydrophilic implant with longer hydrophilic effect retention time can be rapidly obtained before an implant surgery, besides, pollution caused by an organic carbide on the surfaceof the implant can be reduced, and the oxygen content can be increased, so that the surface of the implant can adsorb more bioactive substances and osteogenic protein, and combination of the implantwith bone is promoted. The activated implant after activation treatment has a low surface contact angle, can keep hydrophilic performance for a longer time, and has higher content of surface oxygen and titanium and lower content of polluting elements.

The invention relates to a biological surgery patch and a preparation method thereof and belongs to the technical field of biological materials. The preparation method includes: using a bacterial cellulose membrane prepared by biological fermentation as the base material; subjecting the bacterial cellulose membrane to purification, oxidation, freeze thawing, composite process processing, electrostatic spinning, freeze drying and membrane pressing to obtain the biological surgery patch. The biological surgery patch prepared by the method is good in biocompatibility, mechanical performance, sewing performance and clinical application convenience and capable of satisfying the basic requirements of surgery patch materials.

The invention provides a preparation method of a porous oral implant. The preparation method comprises the following steps: preparing alloy powder into the porous implant through a selective laser melting process; and carrying out vacuum heat treatment on the porous implant and then carrying out furnace cooling to obtain the porous oral implant. By adopting a specific heat treatment process, particularly aiming at a TTNZ alloy porous material prepared by 3D printing of specific components, the compressive strength of the material can be greatly improved, so that the mechanical property of theTTNZ porous oral implant meets the clinical use requirements. The compression strength of the TTNZ porous oral implant prepared by the method is 269-320 MPa, the elastic modulus of the TTNZ porous oral implant is 10-20 GPa, and the implant has good comprehensive mechanical properties.

The invention discloses a tissue anastomat made by low-temperature phase-change memory alloy. The tissue anastomat comprises a suture line and a non-damage medical suture line fixedly connected with one end or two ends of the suture line. The suture line is a titanium-nickel alloy wire which has a linear memory shape in the range from 18 to 26 DEG C. The tissue anastomat made by low-temperature phase-change memory alloy has following beneficial effects: with a product, the suture line is at the conventional room temperature ranging from 18 to 26 DEG C in an operating room; after the package of the product is opened, the suture line naturally restores in the linear memory state; before stitching, the suture line is shaped under effect of external force; after stitched into a human body, the suture line again restores in the linear memory state; and purposes of conducting an intradermal suture operation smoothly, improving saturation precision of the operation and decreasing the duration for saturation of operation are fulfilled.

The invention provides a method for separating umbilical cord mesenchymal stem cell simply and effectively, which comprises the steps of separating umbilical cord mesenchymal stem cell with cannulas, digesting umbilical cord mesenchymal stem cell with trypLETM and cultivating umbilical cord mesenchymal stem cell with a serum-free medium. According to the method, an umbilical cord mesenchymal stem cell from a mother's body completely can be obtained relatively fast, and damage on the cell is relatively low; tests show that according to the method, mesenchymal stem cell can be protected to the most extent, the motility rate as well as the activity is relatively high, and adipogenesis and osteogenic induced differentiation can be carried out effectively.

The invention discloses a cedar fiber bionic traditional Chinese medicine bonesetting splint and a manufacturing method thereof.The manufacturing method comprises the following steps that after cedar is smashed into cedar fibers, soda boiling, cleaning, sterilization and disinfection, secondary cleaning, drying and secondary smashing are conducted, and pretreated cedar fibers are obtained; blending the pretreated cedar fiber and a thermoplastic high polymer material, extruding and granulating, and extruding into a filamentous structure to obtain a filament segment; and after the wire sections are filled into a cold pressing mold in the same direction, the nano-particle dispersion liquid is sprayed into the cold pressing mold, the cold pressing mold is oscillated, the wire sections in the cold pressing mold are subjected to cold pressing, and the plate is obtained. After the plate is placed on a traditional Chinese medicine bonesetting splint mold with a needle-shaped structure, hot pressing is conducted, and the cedar fiber bionic traditional Chinese medicine bonesetting splint is obtained. The cedar fiber is used as a matrix and is cross-linked with the high-molecular low-temperature thermoplastic biological material, the nano inorganic material is combined, and the novel bionic bonesetting splint which is light in weight, breathable, high in longitudinal strength and high in transverse plasticity is prepared through the extrusion and cold pressing technology.

The invention discloses an ointment plaster capable of treating cold womb and a preparation method of the ointment plaster, and relates to the field of external ointment. The ointment plaster is prepared from active components, plant essential oil, ointment forming seasoning and non-woven fabrics, wherein the active components are prepared from the following raw materials in parts by weight of 15-40 parts of motherwort, 10-30 parts of radix astragali, 5-15 parts of radix angelica sinensis, 5-15 parts of poria cocos, 10-20 parts of licorice roots, 10-15 parts of ligusticum wallichii, 5-10 partsof Chinese wolfberry fruits, 5-10 parts of roots of herbaceous peonies, 1-5 parts of radix ginseng rubra, 5-10 parts of cornu cervi pantotrichum, 5-15 parts of radix rehmanniae, 5-13 parts of costusroots and 3-8 parts of radix achyranthis bidentatae. The ointment plaster disclosed by the invention has remarkable treatment effects on female cold womb; and the added raw materials are mutually coordinated but are not mutually influenced, so that the medicine effects are safe, stable and long-lasting, no side effects exist, the cold womb does not relapse after being healed, the quality of the drug namely the ointment plaster is uniform and stable, and the ointment plaster has wide application prospects.

The invention discloses a degradable Zn-Li-X series alloy wire and a preparation method thereof. The degradable Zn-Li-X series alloy wire comprises the following components including, by mass, larger than 0 and smaller than or equal to 1 wt.% of Li, larger than 0 and smaller than or equal to 5 wt.% of X and the balance Zn, wherein X is at least one element of Mn, Cu, Mg and Ca. The degradable Zn-Li-X series alloy wire is prepared through the procedures of smelting, casting, hot extrusion, cold drawing, heat treatment and the like. The obtained zinc alloy wire has excellent plasticity and high tensile strength, and can be automatically degraded and metabolized after being implanted into a human body.

The invention provides a processing method for activity stability of enzyme in human serum, comprising the following steps: step 1: collecting serum; step 2: removing unstable ingredients; step 3: removing impurities such as fibrins and the like; step 4: carrying out aseptic treatment; step 5: conducting split charging and storing; and step 6: inspecting aseptic state. In the invention, the human serum having the same substrate with the sample to be measured is used for effectively solving the problem of interoperability; the collected human serium is processed by a series of technologies so that the enzyme activity in the human serum can keep stable within a period, thus meeting the clinic requirement; and the activity of the enzyme in the human serum prepared by the processing method can be kept stable for more than one year.

The invention discloses a high-sensitivity and high-specificity composition for nucleic acid detection and application of the composition in a detection kit. The composition comprises a first upstream primer F1, a second upstream primer F2, a probe P, a downstream primer R and oligonucleotide F1C, the first upstream primer consists of the following two parts in sequence from the 5'end to the 3 'end: (1) a mismatching region which is not complementarily paired with a target nucleic acid sequence; the sequence of the mismatching region comprises a sequence which is the same as the sequence of the second upstream primer and a sequence which is the same as the sequence of the probe from the 5'end to the 3 'end; and (2) a matching region: performing complementary pairing with a target nucleic acid sequence. Compared with the prior art, the primer probe composition provided by the invention has the remarkable advantages of high sensitivity, good specificity, low cost and the like, is suitable for nucleic acid detection of various sample types, and has extremely high application value.

The invention provides a preparation method of a placenta source matrix mesenchymal stem cell. The preparation method comprises the following steps: (1) separating the placenta source matrix mesenchymal stem cell; (2) cultivating the placenta source matrix mesenchymal stem cell, wherein a trypLE<TM> enzyme solution is utilized to process a placenta tissue in two steps in the step (1), and a serum-free medium is utilized in the step (2). By adopting the method provided by the invention, the placenta source matrix mesenchymal stem cell is a complete matrix source by short tandem repeat sequence (STR) atlas analysis, and is qualified by chromosome karyotype examination, pathogenic microorganism examination of bacteria, funguses and viruses, cell purity identification and cell biology function identification. Therefore, the placenta source matrix mesenchymal stem cell obtained by the method provided by the invention does not contain foreign protein, can meet the requirements of clinical use, is especially suitable for use by mothers, and also provides a technical support for building an excellent placenta source matrix mesenchymal stem cell bank.

Disclosed is an implant-type, completely bioabsorbable, vascular polymer stent comprising five or more annular corrugated support struts (1), and connecting struts (2) spaced apart and connected between the support struts (1). The support struts (1) are formed by corrugations resembling an "Ω" shape (3) and corrugations resembling an "m" shape (4) being alternately connected with each other, wherein the corrugations resembling an "Ω" shape (3) and the corrugations resembling an "m" shape (4) are respectively composed of two sets of upright "s" parts and inverted "s" parts connected together, and the connection between two adjacent support struts (1) is formed by means of the connecting struts (2) connecting the top of the corrugations resembling an "Ω" shape (3) and the bottom of the corrugations resembling an "m" shape (4). The stent balances radial supporting force, wall thickness and flexibility, has good passing-through performance, can also provide sufficient mechanical support at a lesion segment for a specified period of time for wound healing, and is be gradually absorbed by the body after the wound heals, with good endothelialisation, thereby effectively reducing the stent restenosis rate and the risk of late stent thrombosis.