50results about How to "Meet the needs of clinical use" patented technology

The embodiment of the invention provides a medical data processing method, a medical data processing device, a computer readable medium and an electronic device. The method includes the steps of determining a disease recommended treatment scheme according to obtained illness state parameters of a current patient and medical experience, conducting matching in a medical history of historical patients to determine target medical history information according to the illness state parameters, and using the recommended treatment scheme and the target medical history information as medical decision making information of the current patient. Through the medical decision making information of the current patient determined by the technical scheme, the diagnosis and treatment scheme of the current patient is determined; meanwhile, considering the two factors of medical experience and clinical medical history, the management and analysis result practicability based on medical data can be easily improved, and then the obtained medical decision making information for disease treatment meets clinical use requirements.

The invention discloses a magnetic resonance diffusion imaging method for integration and reconstruction based on a Gaussian diffusion model acting as an instance. The method comprises the steps that signal acquisition is performed on a tested target based on multilayer simultaneously excited preset sequences; phase estimation is performed on the acquired under-sampled signals through a parallel imaging technology; the Gaussian diffusion model is established through the estimated phase, the acquired under-sampled signals and a reference image without diffusion weight; the under-sampled signals of all the directions are integrated according to the Gaussian diffusion model, and a target equation is established; the target equation is iteratively solved by using a nonlinear conjugate gradient algorithm so as to obtain a diffusion tensor parameter; and a diffusion coefficient and a diffusion weight image are calculated according to the diffusion tensor parameter. Therefore, high acceleration acquisition of magnetic resonance diffusion tensor imaging can be realized so that the acquisition time can be effectively reduced, the diffusion tensor parameter can be accurately estimated to obtain the diffusion image of high signal-to-noise ratio and high resolution, and the requirement of clinical application can be met.

The invention relates to the manufacturing of a nail, in medical equipment industry. It twists the linear material for making nails tightly to the symmetrical slant mold, intersecting the linear material to form the nail with each having two feet, each having a symmetrical slant surface. In this way, the binding machine used nails is realized mass production. With natural occurrence of two slant surfaces of the nail feet, symmetrical in location, consistent in shape, high in yield rate, it meets clinical requirement. It is simple, high in efficiency, low in cost, good in implementation effect, and with advances in this field.

The invention provides a preparation method of a placenta source matrix mesenchymal stem cell. The preparation method comprises the following steps: (1) separating the placenta source matrix mesenchymal stem cell; (2) cultivating the placenta source matrix mesenchymal stem cell, wherein a trypLE<TM> enzyme solution is utilized to process a placenta tissue in two steps in the step (1), and a serum-free medium is utilized in the step (2). By adopting the method provided by the invention, the placenta source matrix mesenchymal stem cell is a complete matrix source by short tandem repeat sequence (STR) atlas analysis, and is qualified by chromosome karyotype examination, pathogenic microorganism examination of bacteria, funguses and viruses, cell purity identification and cell biology function identification. Therefore, the placenta source matrix mesenchymal stem cell obtained by the method provided by the invention does not contain foreign protein, can meet the requirements of clinical use, is especially suitable for use by mothers, and also provides a technical support for building an excellent placenta source matrix mesenchymal stem cell bank.

The invention relates to nano calcium phosphate bone cement and a preparation method thereof. The nano calcium phosphate bone cement is prepared by the steps of adding a water soluble nanomaterial into calcium phosphate bone cement; and uniformly mixing the mixture and self-curing the mixture to obtain the nano calcium phosphate bone cement. The nano bone cement is prepared by mixing a metal nanomaterial which is good in biocompatibility with bone cement matrix powder. The material not only has a good mechanical property, but also has the enhanced osteogenic activity. The performance of the nano bone cement can be adjusted by adjusting the type and quantity of the nanomaterial, for example, the bone cement is endowed with a magnetic property by adding a magnetic nanomaterial, and the strength of the bone cement is enhanced by increasing the additive amount of the nanomaterial in a certain range. The preparation method of the nano bone cement provided by the invention is simple in process and high in operability, can better meet the clinical use demand and has promotional value.

The invention belongs to the technical field of ultrasonic equipment, and relates to a puncture frame structure body and ultrasonic puncture equipment; the puncture frame structure body comprise a puncture frame and a puncture needle seat which is connected to the puncture frame and can be rotationally adjusted; the puncture frame comprises a first surface with a first end and a second end, and the puncture frame is constructed to be connected to an ultrasonic probe of ultrasonic puncture equipment; the puncture needle seat comprises an adjusting end and a needle base end, a plurality of puncture guide channels are formed in the needle base end, and included angles are formed between longitudinal axes of the puncture guide channels. The guide device can correspondingly adjust the punctureangle according to clinical needs.

The invention discloses a high-sensitivity nucleic acid sequence detection composition and a detection method. The composition comprises a first upstream primer, a second upstream primer, a probe anda downstream primer, wherein the first upstream primer is sequentially composed of the following two parts from a 5' end to a 3' end of (1) a non-matching area, wherein complementary pairing does notoccur with a target nucleic acid sequence; the sequence of the non-matching area from the 5' end to the 3' end comprises the same sequence as the second upstream primer, and the same sequence as the probe; and (2) a matching area, wherein complementary pairing occurs with the target nucleic acid sequence. Compared with the prior art, the primer probe composition provided by the invention has the remarkable advantages of high sensitivity, high specificity, low cost and the like, is suitable for nucleic acid detection of various sample types, and has extremely high application value.

The invention discloses a transdermal drug delivery system of high-solubility ibuprofen or a structural analog of the ibuprofen. The transdermal drug delivery system comprises a polymer matrix layer,and the polymer matrix layer contain active ingredients, pressure sensitive adhesive and compounds for regulating and controlling the solubility of the active ingredients, wherein the compounds comprise first polymer hyrdroxypropyl methylcellulose acetate succinate (HPMCAS) and a second polymer compound; and the second polymer compound comprises pharmaceutically acceptable fat-soluble polymers and / or amphiphilic polymers. According to the transdermal drug delivery system, by selecting the types, the using amount and the proportion of the first polymer HPMCAS and the second polymer compound, the solubility, the releasing speed and the transdermal diffusion rate of the ibuprofen or the structural analog of the ibuprofen in the transdermal drug delivery system can be selectively regulated andcontrolled; through joint action of the HPMCAS and the second polymer compound, the soluble state of the ibuprofen or the structural analog of the ibuprofen in a polymer matrix can be maintained, crystallization of the ibuprofen or the structural analog of the ibuprofen can be inhibited, and the ibuprofen or the structural analog of the ibuprofen can be preserved stably for a long term; and a production process is easy, convenient, controllable and economical.

The invention relates to a biological surgery patch and a preparation method thereof and belongs to the technical field of biological materials. The preparation method includes: using a bacterial cellulose membrane prepared by biological fermentation as the base material; subjecting the bacterial cellulose membrane to purification, oxidation, freeze thawing, composite process processing, electrostatic spinning, freeze drying and membrane pressing to obtain the biological surgery patch. The biological surgery patch prepared by the method is good in biocompatibility, mechanical performance, sewing performance and clinical application convenience and capable of satisfying the basic requirements of surgery patch materials.

The invention provides a method for separating umbilical cord mesenchymal stem cell simply and effectively, which comprises the steps of separating umbilical cord mesenchymal stem cell with cannulas, digesting umbilical cord mesenchymal stem cell with trypLETM and cultivating umbilical cord mesenchymal stem cell with a serum-free medium. According to the method, an umbilical cord mesenchymal stem cell from a mother's body completely can be obtained relatively fast, and damage on the cell is relatively low; tests show that according to the method, mesenchymal stem cell can be protected to the most extent, the motility rate as well as the activity is relatively high, and adipogenesis and osteogenic induced differentiation can be carried out effectively.

The invention discloses a cedar fiber bionic traditional Chinese medicine bonesetting splint and a manufacturing method thereof.The manufacturing method comprises the following steps that after cedar is smashed into cedar fibers, soda boiling, cleaning, sterilization and disinfection, secondary cleaning, drying and secondary smashing are conducted, and pretreated cedar fibers are obtained; blending the pretreated cedar fiber and a thermoplastic high polymer material, extruding and granulating, and extruding into a filamentous structure to obtain a filament segment; and after the wire sections are filled into a cold pressing mold in the same direction, the nano-particle dispersion liquid is sprayed into the cold pressing mold, the cold pressing mold is oscillated, the wire sections in the cold pressing mold are subjected to cold pressing, and the plate is obtained. After the plate is placed on a traditional Chinese medicine bonesetting splint mold with a needle-shaped structure, hot pressing is conducted, and the cedar fiber bionic traditional Chinese medicine bonesetting splint is obtained. The cedar fiber is used as a matrix and is cross-linked with the high-molecular low-temperature thermoplastic biological material, the nano inorganic material is combined, and the novel bionic bonesetting splint which is light in weight, breathable, high in longitudinal strength and high in transverse plasticity is prepared through the extrusion and cold pressing technology.

The invention discloses a high-sensitivity and high-specificity composition for nucleic acid detection and application of the composition in a detection kit. The composition comprises a first upstream primer F1, a second upstream primer F2, a probe P, a downstream primer R and oligonucleotide F1C, the first upstream primer consists of the following two parts in sequence from the 5'end to the 3 'end: (1) a mismatching region which is not complementarily paired with a target nucleic acid sequence; the sequence of the mismatching region comprises a sequence which is the same as the sequence of the second upstream primer and a sequence which is the same as the sequence of the probe from the 5'end to the 3 'end; and (2) a matching region: performing complementary pairing with a target nucleic acid sequence. Compared with the prior art, the primer probe composition provided by the invention has the remarkable advantages of high sensitivity, good specificity, low cost and the like, is suitable for nucleic acid detection of various sample types, and has extremely high application value.

The invention provides a preparation method of a placenta source matrix mesenchymal stem cell. The preparation method comprises the following steps: (1) separating the placenta source matrix mesenchymal stem cell; (2) cultivating the placenta source matrix mesenchymal stem cell, wherein a trypLE<TM> enzyme solution is utilized to process a placenta tissue in two steps in the step (1), and a serum-free medium is utilized in the step (2). By adopting the method provided by the invention, the placenta source matrix mesenchymal stem cell is a complete matrix source by short tandem repeat sequence (STR) atlas analysis, and is qualified by chromosome karyotype examination, pathogenic microorganism examination of bacteria, funguses and viruses, cell purity identification and cell biology function identification. Therefore, the placenta source matrix mesenchymal stem cell obtained by the method provided by the invention does not contain foreign protein, can meet the requirements of clinical use, is especially suitable for use by mothers, and also provides a technical support for building an excellent placenta source matrix mesenchymal stem cell bank.

The invention discloses a tissue anastomat made by low-temperature phase-change memory alloy. The tissue anastomat comprises a suture line and a non-damage medical suture line fixedly connected with one end or two ends of the suture line. The suture line is a titanium-nickel alloy wire which has a linear memory shape in the range from 18 to 26 DEG C. The tissue anastomat made by low-temperature phase-change memory alloy has following beneficial effects: with a product, the suture line is at the conventional room temperature ranging from 18 to 26 DEG C in an operating room; after the package of the product is opened, the suture line naturally restores in the linear memory state; before stitching, the suture line is shaped under effect of external force; after stitched into a human body, the suture line again restores in the linear memory state; and purposes of conducting an intradermal suture operation smoothly, improving saturation precision of the operation and decreasing the duration for saturation of operation are fulfilled.