Tannin ointment for treating eczema and preparation method thereof

A technology of tannic acid and ointment, applied in the field of tannic acid ointment and its preparation, can solve the problems of skin irritation, patients are prone to repeated attacks, and poor treatment effect, so as to reduce irritation, adjust cell osmotic pressure, and enhance treatment effect Effect

Active Publication Date: 2017-09-15
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most patients are prone to recurrent attacks, making the disease chronic, with severe skin lesions and severe itching, making clinical treatment difficult
The existing tannic acid ointment for the treatment of eczema has problems such as poor therapeutic effect, long healing time, long-term use and irritation to the skin, etc.

Method used

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  • Tannin ointment for treating eczema and preparation method thereof
  • Tannin ointment for treating eczema and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 drug irritation test

[0023] The preparation method of prescription 1-8 ointment is specifically carried out as follows:

[0024] (1) It is standby to weigh by the components and their consumptions described in Table 1;

[0025] (2) Dissolve tannic acid with glycerin to obtain a glycerin tannin solution, add betaine and sodium bisulfite to the glycerin tannin solution, heat to 75°C, stir and mix evenly, keep the temperature at 75°C, and keep warm Time is 40 minutes, makes component A;

[0026] (3) Heating vaseline, maple gum, and Tween-80 to 80°C, stirring and mixing evenly, keeping the temperature at 80°C, and holding time for 30 minutes to prepare component B;

[0027] (4) Heat component A and component B to 80°C respectively, add the component A to the component B, stir evenly while adding, and keep the temperature at 80°C, the holding time is 30 minutes . Cool to room temperature to prepare tannic acid ointment.

[0028] Table 1 Prescriptions of e...

Embodiment 2

[0039] Embodiment 2: the tannic acid ointment for the treatment of eczema is made from the following raw materials in proportion by weight: 60 parts of tannic acid, 240 parts of glycerin, 30 parts of maple gum, 30 parts of betaine, 360 parts of vaseline, 24 parts of Tween-80, Sodium bisulfite 2 parts.

[0040] (1) Dissolve tannic acid with glycerin to obtain tannic acid glycerol solution. Then add betaine and sodium bisulfite, heat to 75°C, stir and mix evenly, keep the temperature at 75°C, and keep warm for 40 minutes to prepare component A.

[0041] (2) Heat vaseline, liquidambar gum, and Tween-80 to 80°C, stir and mix evenly, and keep the temperature at 80°C for 30 minutes to prepare component B.

[0042] (3) Heat component A and component B to 80°C respectively, add component A to component B, stir evenly while adding, keep the temperature at 80°C, and hold for 30 minutes. Cool to room temperature to prepare tannic acid ointment.

Embodiment 3

[0043] Embodiment 3: the tannic acid ointment for the treatment of eczema is made from the raw materials of subordinate weight ratio: 60 parts of tannic acid, 240 parts of glycerin, 30 parts of betaine, 360 parts of petrolatum, 24 parts of Tween-80, sodium bisulfite 2 share.

[0044] The only difference between the preparation method and Example 2 is that no maple gum is added.

[0045] Rabbits with skin damage or ulcers, guinea pigs are used for experimental research, and the results show that the tannic acid ointment described in Examples 2 and 3 can reduce the exudation of plasma at the wound, and promote the healing of the scab on the damaged skin.

[0046] The tannic acid ointment described in Examples 2 and 3 was used on 500 patients with eczema clinically. According to the feedback from the patients, it was found that the tannic acid ointment of Example 2 had a better therapeutic effect and a faster curative effect. Generally, the symptoms improved significantly after o...

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Abstract

The invention relates to a tannin ointment and a preparation method thereof. The tannin ointment is prepared from tannin, glycerin, resina liquidambaris, betaine, Vaseline, tween-80, and sodium bisulfite. The preparation method of the tannin ointment comprises the following steps of dissolving the tannin by the glycerin, so as to obtain a tannin glycerin solution; adding the betaine and the sodium bisulfite, heating, and uniformly stirring, so as to obtain a component A; heating the Vaseline, the resina liquidambaris and the tween-80, and uniformly stirring, so as to obtain a component B; heating the component A and the component B to 75 to 80 DEG C, adding the component A into the component B, uniformly stirring, and cooling to room temperature, so as to obtain the tannin ointment. The tannin ointment has the advantages that the betaine has the functions of sterilizing bacteria and diminishing inflammation, adjusting cell osmosis pressure, reducing irritation of medicine to skin and the like; the resina liquidambaris has the effects of activating blood circulation and relieving pain, detoxifying, generating muscle and the like, enhances the treatment effect of tannin, and has better synergistic action with the betaine; the resina liquidambaris can be well cooperated with the bataine, so that the effect of reducing the irritation to the skin by the medicine is more obvious under the synergistic action of the resina liquidambaris and the bataine.

Description

technical field [0001] The invention relates to a tannic acid ointment and a preparation method thereof, belonging to the field of medicine and preparation technology, and is mainly used for treating eczema, and can also be used for treating bedsores, diaper rash and the like. Background technique [0002] Tannic acid, also known as tannic acid and tannin, is a yellow or light brown light-weight amorphous powder or scale substance extracted from gallnuts. Odorless, slightly special smell. Soluble in water and ethanol, also soluble in glycerin. Tannic acid can precipitate protein. After the skin, mucous membranes, and ulcers are exposed to tannic acid, the tissue protein is coagulated to form a film and has astringent effect. Topical application can treat exudative ulcers, bed sores, eczema, burns, etc. It is also used for detoxification. It can form insoluble complexes with alkaloids, glycosides and heavy metals, so it can be used as a chemical antidote. [0003] The chem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/06A61P17/00A61P37/08A61P17/02A61K31/7024A61K31/205
CPCA61K9/0014A61K9/06A61K31/205A61K31/7024A61K36/185A61K47/26A61K2300/00
Inventor 赵志超张建楠田蓓金志敏
Owner ZHEJIANG UNIV OF TECH
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