A kind of calcium phosphate bone cement embedding drug-loaded siliceous body and its preparation method and application

A technology of calcium phosphate bone cement and siliceous body, which is applied in pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problems of drug release rate reduction, improve injectability, improve biocompatibility, and simple preparation method Effect
CN107158473BActive Publication Date: 2019-12-27SHANGHAI NAT ENG RES CENT FORNANOTECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI NAT ENG RES CENT FORNANOTECH
Publication Date
2019-12-27

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Abstract

The invention relates to medicine-loaded siliceous body embedded calcium phosphate bone cement and a preparation method and application thereof. The preparation method comprises the following steps: mixing a self-curing component and a heating nanomaterial to obtain modified bone cement solid powder, wherein an alpha-tricalcium phosphate material plays embedding and carrying roles and a paclitaxel@siliceous body plays an anti-cancer role; with sodium phosphate as a main body and phosphorylated chitosan, hydroxypropyl methyl cellulose and gelatin as modifiers, preparing a neutral bone cement curing solution which improves injectability of a formula; mixing the bone cement solid powder and the curing solution, wherein a main component hydroxyapatite of a cured product is added and the paclitaxel@siliceous body has very good degradability in a living body. The preparation method is simple and convenient, used raw materials are simple, and the preparation method is suitable for mass production; the develop medicine-loaded novel formula improves the biocompatibility of the original bone cement; through addition of the paclitaxel@siliceous body with a thermotherapeutic effect, the injectability of the medicine-loaded siliceous body embedded calcium phosphate bone cement is improved.
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Description

technical field

[0001] The invention relates to a method in the technical field of biomedical materials, in particular to a drug-loaded siliceous body calcium phosphate bone cement and its preparation method and application.

[0002] technical background

[0003] Bone tumor is a tumor that occurs in bone or its subsidiary tissues (blood vessels, nerves, bone marrow, etc.), and is a common disease. Like other tissues in the body, its exact cause is unknown. Tumors are divided into benign tumors and malignant tumors. Benign tumors are easy to remove, generally do not metastasize or recur, and only squeeze and block organs and tissues. Malignant tumors destroy the structure and function of tissues and organs, together with necrosis, bleeding and infection, which seriously threaten human life. Bone tumors or tumor-like lesions are mainly surgical curettage or resection. Tumor surgery strives to be thorough to avoid recurrence or malignant transformation. After surgical resecti...

Claims

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