Aegiceras corniculatum stem ethyl acetate extract and preparation method and application thereof to prostatic cancer treatment

A stem ethyl acetate, prostate cancer technology, applied in the application field of tung flower stem ethyl acetate extract and its preparation and treatment of prostate cancer, can solve the problems of reducing the quality of life of patients and large side effects

Inactive Publication Date: 2017-09-19
GUANGXI UNIV OF CHINESE MEDICINE
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Problems solved by technology

At present, the medical treatment of prostate cancer is mainly based on Western medicine, but the side effects are relatively large, which greatly reduces the quality o

Method used

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  • Aegiceras corniculatum stem ethyl acetate extract and preparation method and application thereof to prostatic cancer treatment
  • Aegiceras corniculatum stem ethyl acetate extract and preparation method and application thereof to prostatic cancer treatment
  • Aegiceras corniculatum stem ethyl acetate extract and preparation method and application thereof to prostatic cancer treatment

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Embodiment Construction

[0016] One, the preparation of tung flower stem ethyl acetate part extract (EACS)

[0017] 1. Medicinal materials: Tung flower stems were collected in Fangchenggang, Guangxi, and identified by Xu Mingben, Guangxi Beibu Gulf Marine Research Center as the stem of Tung flower tree, a plant of the family Taurus.

[0018] 2. Extraction and separation: dry the tung flower stem and beat it into a coarse powder (2500g), add 25 times the amount (62.5L) of 95% ethanol and soak for 7 days; obtain the total ethanol extract of the tung flower stem by concentrating under reduced pressure, Dissolve the total ethanol extract with pure water to form a suspension, volatilize until there is no ethanol smell, then add petroleum ether for extraction to obtain the lower aqueous phase, add ethyl acetate to the lower aqueous phase to continue the extraction, and obtain the upper layer of ethyl acetate. The extract from the ethyl acetate part of the upper layer was dried in a water bath to obtain the ...

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Abstract

The invention discloses an aegiceras corniculatum stem ethyl acetate extract and a preparation method thereof. The method includes: soaking aegiceras corniculatum stems into ethanol to obtain aegiceras corniculatum stem ethanol extract; after volatilization of ethanol in the aegiceras corniculatum stem ethanol extract, adding petroleum ether for extraction to obtain a lower water phase; adding ethyl acetate into the lower water phase, continuing extraction to obtain upper ethyl acetate part extract, and performing water bath drying to obtain the aegiceras corniculatum stem ethyl acetate extract. According to in-vitro molecular biological experiment researches, the aegiceras corniculatum stem ethyl acetate extract has an anti-proliferation effect on human prostatic cancer cells PC3 and DU145 and is capable of evidently inhibiting clone formation of the human prostatic cancer cells PC3 and DU145. Therefore, the aegiceras corniculatum stem ethyl acetate extract has a potential application prospect in preparation of medicines for treating prostatic cancer and can be used for preparation of the medicines for treating prostatic cancer. Deeply developing the aegiceras corniculatum stem ethyl acetate extract can expand an aegiceras corniculatum utilization range to create a novel approach for cancer treatment.

Description

technical field [0001] The invention belongs to the technical field of tung flower tree, and in particular relates to an ethyl acetate extract of tung flower tree stem and its preparation and application for treating prostate cancer. Background technique [0002] Tung flower tree (Aegiceras corniculatum (Linn.) Blanco) is a mangrove plant of the genus Aegiceras of the genus Aegiceras in the family Myrsinaceae. It is born in coastal tidal flats and distributed in Hainan, Fujian, Guangdong, Guangxi, Zhejiang, Hong Kong, Macao and other places in my country. , India, Indochina Peninsula to the Philippines and southern Australia are also produced. In traditional applications, the bark and leaves of the tung flower tree are boiled to treat diseases such as asthma, diabetes and rheumatism. Modern pharmacological studies have shown that the tung flower tree has obvious pharmacological activities such as antibacterial, anti-inflammatory and analgesic, anti-oxidation, and cytotoxicity...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P13/08A61P35/00A61K135/00
CPCA61K36/185A61K2236/333A61K2236/35A61K2236/39A61K2236/51
Inventor 郝二伟罗花邓家刚侯小涛杜正彩易湘西谭德超谢滟冯小慧
Owner GUANGXI UNIV OF CHINESE MEDICINE
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