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Liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate, composition containing clathrate, and preparation method and novel application of clathrate

A technology of cyclodextrin and derivatives, applied in the application field of deep processing of liquiritigenin, can solve the problems of poor absorption, poor solubility, poor solubility of liquiritigenin and the like

Active Publication Date: 2017-09-22
宁夏蓝博思化学技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Liquiritigen has the pharmacological activity of eliminating free radicals and anti-oxidation, but its solubility in water is poor, and its absorption is poor when taken. Therefore, it is necessary to solve the problem of poor solubility of liquiritigenin and poor absorption by the human body
[0008] There is no report about the preparation technology of glycyrrhizin-cyclodextrin or cyclodextrin derivative inclusion compound, and the research on its inclusion compound and composition for anti-exercise fatigue

Method used

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  • Liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate, composition containing clathrate, and preparation method and novel application of clathrate
  • Liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate, composition containing clathrate, and preparation method and novel application of clathrate
  • Liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate, composition containing clathrate, and preparation method and novel application of clathrate

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Example 1: Preparation method of glycyrrhizin-β-cyclodextrin inclusion compound

[0030] Take 1mmol of β-cyclodextrin, add 60g of water to dissolve, add 1mmol of liquiritigenin while stirring at room temperature, and continue to stir, so that the β-cyclodextrin and liquiritigenin are completely reacted. After the reaction is completed, a solution is obtained, and the above solution is Filter with a microporous membrane, pre-freeze the filtrate in a refrigerator at -80°C for 4 hours, and then dry it overnight at -80°C with a freeze dryer to obtain a solid inclusion compound of liquiritigenin-β-cyclodextrin.

Embodiment 2

[0031] Example 2: Preparation method of glycyrrhizin-β-cyclodextrin inclusion compound

[0032] Take 10mmol of β-cyclodextrin, add 600g of water to dissolve, add 1mmol of liquiritigenin while stirring at room temperature, and continue to stir, so that the β-cyclodextrin and liquiritigenin are completely reacted. After the reaction is completed, a solution is obtained, and the above solution is Filter with a microporous membrane, pre-freeze the filtrate in a refrigerator at -80°C for 4 hours, and then dry it overnight at -80°C with a freeze dryer to obtain a solid inclusion compound of liquiritigenin-β-cyclodextrin.

Embodiment 3

[0033] Example 3: Preparation method of glycyrrhizin-hydroxypropyl-β-cyclodextrin inclusion compound

[0034] Take 1mmol of hydroxypropyl-β-cyclodextrin, add 10g of water to dissolve, add 1mmol of liquiritigenin while stirring at room temperature, and continue stirring to completely react the hydroxypropyl-β-cyclodextrin and liquiritigenin. After completion, the solution was obtained, and the above solution was filtered with a microporous membrane, and the filtrate was pre-frozen in a refrigerator at -80°C for 4 hours, and then dried overnight at -80°C with a freeze dryer to obtain a solid liquiritigenin-hydroxypropyl-β-cyclogluter Fine clathrate.

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Abstract

The invention relates to a liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate, a composition containing the clathrate, and a preparation method and novel application of the clathrate; the application of the liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate in the preparation of drugs for improving or treating exercise-induced fatigue, and the pharmaceutical composition are prepared by the inventor during the study on the liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate by: establishing an animal model, and detecting change levels of hepatic glycogen, blood lactic acid and urea nitrogen in a mouse sample; it is verified that liquiritigenin can resist exercise-induced fatigue, and the pharmaceutical composition for resisting exercise-induced fatigue is prepared.

Description

technical field [0001] The invention belongs to the application technical field of deep processing of glycyrrhizin, and in particular relates to a glycyrrhizin-cyclodextrin or cyclodextrin derivative inclusion compound and composition, a preparation method and a new application. Background technique [0002] Exercise-induced fatigue is an eternal theme in the research of sports medicine and exercise physiology. Regarding the formation mechanism of exercise-induced fatigue, various hypotheses have been put forward, such as the theory of energy material depletion, the theory of free radical damage, the theory of neurotransmitters, the theory of lactic acid accumulation and the theory of Ca 2+ Steady-state anomaly theory, etc. [0003] The theory of exhaustion of energy substances proposes that energy substances include various glycogen, ATP, creatine phosphate, etc. During short-term high-intensity exercise, the body will use a large amount of energy substances such as glycog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K31/352A61P39/00
CPCA61K31/352
Inventor 戈胡蓉褚慧敏罗生霞孙涛黄青魏世杰王志忠
Owner 宁夏蓝博思化学技术有限公司
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