Topical application of nerve labeling dyes for image-guided surgery

A technology of drugs and reagents, applied in the field of neuroimaging, which can solve problems such as limiting systemic absorption and enhancing the safety properties of contrast agents

Active Publication Date: 2017-09-22
GENERAL ELECTRIC CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It may potentially limit the possibility of systemic absorption and toxicity, thereby enhancing the safety properties of contrast media

Method used

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  • Topical application of nerve labeling dyes for image-guided surgery
  • Topical application of nerve labeling dyes for image-guided surgery
  • Topical application of nerve labeling dyes for image-guided surgery

Examples

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Embodiment

[0138] The following non-limiting examples are shown and describe various embodiments of the invention. The examples include data obtained comparing systemically administered contrast agents with intraoperative localized application of nerve-marking contrast agents. As shown, it was demonstrated that when properly formulated, topically administered nerve-labeling contrast agents can be administered in a much faster time, at lower doses, and with better nerve-to-muscle The contrast selectively labels nerves. In vitro characterization of contrast agents:

[0139] In 100% dimethyl sulfoxide (DMSO), anhydrous methanol (MeOH) and distilled / deionized water (ddH 2 (0) Absorption spectra of reagents were measured using a Lambda 20 UV / Vis spectrometer (Perkin Elmer, Waltham, MA) in the wavelength range from 200 to 800 nm. The wavelength of absorbance maximum was then used as the excitation wavelength for collecting fluorescence emission spectra on a steady-state fluorometer (Photon ...

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Abstract

The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.

Description

[0001] Federally Sponsored Research and Development [0002] This invention was made with Government support under Contract No. R01 EB011872 awarded by the National Institutes of Health through the National Institute of Biomedical Imaging and Bioengineering. The government has certain rights in this invention. technical field [0003] The present invention relates to fluorescence-guided neuroimaging during surgery, and in particular to the field of intraoperative local administration of myelin basic protein (MBP) neuroimaging contrast agents. Also provided are pharmaceutical formulations for local administration of the contrast agent to allow intraoperative nerve identification. Background technique [0004] Accidental nerve injury is a major cause of morbidity associated with many life-saving surgical procedures. Complications resulting from these injuries depend on the severity and location of nerve damage and often result in symptoms that negatively impact the patient's...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D295/26C09K11/06A61K49/00
CPCA61K49/0021C07D295/26A61K49/0054A61K49/0071A61P41/00A61P43/00A61K49/0019A61K49/12A61K49/10A61K51/04A61B5/055A61B5/0068A61B5/0071A61B5/0084A61K9/0014A61K47/10A61K47/22A61K47/32
Inventor C.A.谭赫希尔T.M.西克罗文V.E.科特罗
Owner GENERAL ELECTRIC CO
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