An electrospray desorption ionization device for mass spectrometry imaging

Abstract

The present invention discloses an electro-spray desorption ionization device for mass spectrometry imaging. The device comprises a carrier liquid inner tube and a carrier liquid outer tube sleeved at the outer portion of the carrier liquid inner tube, the carrier liquid inner tube is configured to output spray solution applied by high voltage, a carrier gas cone outer tube is configured to output spray auxiliary airflow acted on the spray solution output by the carrier liquid inner tube, and formed electrospray is configured to perform desorption ionization of samples. The device also comprises external airflow field devices arranged at the carrier liquid inner tube and the exit of the carrier gas cone outer tube, and the external airflow field devices apply an airflow field to the electrospray when being controlled to start so as to separate the electrospray from areas where the samples are located. The device can remove noise caused by pollution of samples through spray in the detection motion process, eliminate the fuzzy imaging and improve the imaging resolution while ensuring the continuous and stable spraying.

Description

technical field [0001] The invention relates to an electrospray desorption ionization device for mass spectrometry imaging. Background technique [0002] Mass spectrometry imaging is an instrument for detecting the spatial distribution of material components, which can realize the detection of spatial distribution of solid sample components, antique identification, criminal investigation, judicial identification and other fields. The use of mass spectrometry imaging to detect the spatial distribution of sample components must first convert the solid sample into an ion form, and different ionization methods are generally used for samples of different forms. [0003] For solid samples ionized with high-energy ions by electrospray desorption ionization, often due to the small diameter of the spray capillary, it is difficult to ensure the coaxiality of the inner liquid flow path and the outer air flow path at the tip, and give full play to the effect of the outer air flow on the...

AI Technical Summary

Problems solved by technology

[0003] For solid samples ionized with high-energy ions by electrospray desorption ionization, it is often difficult to ensure that the inner liquid flow path and the outer air flow path are coaxial at the tip because the diameter of the spray capillary is too small, so as to give full play to the effect of the outer air flow on the inner electrospray.

Moreover, stepping motion detection is often used during mass spectrometry imaging, and the continuation of the spray can lead to contamination of the sample when moving between detection points

In the whole imaging process, the short-term opening and closing of the electrospray desorption device cannot achieve the effect of spray stability.

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