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Traditional Chinese medicine composition and application thereof in preparation of drugs for preventing or treating hypertension

A composition and high blood pressure technology, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve problems such as application that have not been reported, and achieve the effects of simple process operation, significant curative effect, and moderate and stable effect.

Inactive Publication Date: 2017-09-29
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the application of salvia miltiorrhiza and Chuanxiong extract powder as a drug combination in the prevention and treatment of hypertension

Method used

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  • Traditional Chinese medicine composition and application thereof in preparation of drugs for preventing or treating hypertension
  • Traditional Chinese medicine composition and application thereof in preparation of drugs for preventing or treating hypertension
  • Traditional Chinese medicine composition and application thereof in preparation of drugs for preventing or treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0018] Mix 178g of Salvia miltiorrhiza and 889g of Rhizoma Chuanxiong to prepare extract powder, then add 600g of microcrystalline cellulose, mix well, and directly press the powder into tablets to obtain tablets.

[0019] Wherein the preparation method of salvia miltiorrhiza and chuanxiong extract powder is as follows:

[0020] Take Salvia miltiorrhiza and Rhizoma Chuanxiong, add water to decoct three times respectively, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second and third times, decoct for 1.5 hours, combine the decoction, filter, The filtrate was concentrated under reduced pressure to a clear paste with a relative density of 1.20-1.25 (50°C). Add ethanol to make the alcohol content reach 75%, and let it stand overnight. Take the supernatant, recover ethanol under reduced pressure, concentrate to a clear paste with a relative density of 1.25-1.35 (50° C.), and dry to obtain extract powder.

preparation Embodiment 2

[0022] Mix 889g of Salvia miltiorrhiza and 889g of Rhizoma Chuanxiong to prepare extract powder, then add 600g of microcrystalline cellulose, mix well, and directly press the powder into tablets to obtain tablets.

[0023] Wherein the preparation method of Salvia Miltiorrhiza Extract Powder and Chuanxiong Extract Powder is as follows:

[0024] Take Salvia miltiorrhiza and Rhizoma Chuanxiong, add water to decoct three times respectively, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second and third times, decoct for 1.5 hours, combine the decoction, filter, The filtrate was concentrated under reduced pressure to a clear paste with a relative density of 1.20-1.25 (50°C). Add ethanol to make the alcohol content reach 75%, and let it stand overnight. Take the supernatant, recover ethanol under reduced pressure, concentrate to a clear paste with a relative density of 1.25-1.35 (50° C.), and dry to obtain extract po...

preparation Embodiment 3

[0026] Take 1600g of Salvia miltiorrhiza and 889g of Chuanxiong to prepare extract powder, then add 600g of microcrystalline cellulose, mix well, and directly press the powder into tablets to obtain tablets.

[0027] Wherein the preparation method of Salvia Miltiorrhiza Extract Powder and Chuanxiong Extract Powder is as follows:

[0028] Take Salvia miltiorrhiza and Rhizoma Chuanxiong, add water to decoct three times respectively, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second and third times, decoct for 1.5 hours, combine the decoction, filter, The filtrate was concentrated under reduced pressure to a clear paste with a relative density of 1.20-1.25 (50°C). Add ethanol to make the alcohol content reach 75%, and let it stand overnight. Take the supernatant, recover ethanol under reduced pressure, concentrate to a clear paste with a relative density of 1.25-1.35 (50° C.), and dry to obtain extract powder. ...

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Abstract

The invention provides a traditional Chinese medicine composition containing salviae miltiorrhizae and ligusticum wallichii extract powder and an application thereof in preparation of drugs for preventing or treating hypertension. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: 1-9 parts of salviae miltiorrhizae and 4-6 parts of ligusticum wallichii extract powder. The traditional Chinese medicine composition is good and stable in antihypertensive effect and free of obvious toxic or side effects.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and its application in preparing medicines for preventing or treating hypertension. Background technique [0002] According to statistics, there are as many as 600 million patients with hypertension worldwide, and with the aging of the population, bad living habits, lack of health education, etc., the prevalence of hypertension and the incidence of complications are high It is an important factor causing various cardiovascular and cerebrovascular diseases, and it is also one of the main factors of death from cardiovascular diseases. In addition to genetic factors, the etiology of high blood pressure, unreasonable dietary structure, excessive intake of sodium salt, and excessive intake of saturated fatty acids can cause increased subcutaneous fat, compression of blood vessels, increased blood lipids, narrowing of blood vessel ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/12A61K36/236
CPCA61K36/236A61K36/537A61K2300/00
Inventor 陈民利潘永明马全鑫
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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