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Acanthopanax-spina date seed oral preparation with calming and tranquilizing effects and preparation method thereof

An oral preparation and technology of Acanthopanax senticosus, which is applied in the field of oral preparations of Acanthopanax senticosus and jujube seed and its preparation, and can solve problems such as hallucinations and convulsions.

Inactive Publication Date: 2017-10-27
哈尔滨宏琪生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many people with insomnia take barbiturates and benzodiazepines, and long-term use of these drugs can produce many side effects, such as anxiety, fear, delusions, hallucinations, and convulsions

Method used

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  • Acanthopanax-spina date seed oral preparation with calming and tranquilizing effects and preparation method thereof
  • Acanthopanax-spina date seed oral preparation with calming and tranquilizing effects and preparation method thereof
  • Acanthopanax-spina date seed oral preparation with calming and tranquilizing effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 The sedative and hypnotic effect of Acanthopanax senticosus and Schisandra chinensis on mice.

[0046] Test method: Using suprathreshold and subthreshold doses of pentobarbital sodium to induce sleep in mice, the sedative and hypnotic effects of Zianzaoren and Acanthopanax senticosus alone and in combination were studied. Using the method of pentobarbital sodium-induced sleep in mice, the dose-effect relationship of Zianzaoren and Acanthopanax senticosus in improving sleep was studied. Results: Suanzaoren can prolong sleep time (P<0.01), the effective dose is 16g / kg, the effective range is 16-128g / kg, and the effect is most significant when the dose is 64g / kg. Acanthopanax can shorten the sleep latency (P<0.05), the effective dose is 3g / kg, the effective range is 3-12g / kg, and the effect is most significant when the dose is 12g / kg. Compared with the blank group, the jujube seed and Acanthopanax combined group can significantly shorten the sleep latency of mic...

Embodiment 2

[0062] Embodiment two (oral liquid preparation)

[0063] Prepare according to the preparation method of the content of the invention:

[0064] 1. Take 250g Acanthopanax and 175g Jujube Seed, add water to decoct twice, add 8 times the amount of water for the first time and decoct for 2 hours, filter the decoction, put the filtrate in a clean container, and set aside; add 6 times the amount of water to the filter residue, Decoct for 1 hour, filter the decoction, combine the filtrate with the filtrate of the first decoction, concentrate, concentrate to a thick paste with a specific gravity of 1.20-1.25, and set aside;

[0065] 2. In the state of stirring, add the above thick paste to the ethanol prepared in advance to make the ethanol content reach 75%, refrigerate and stand still for 48 hours, take the supernatant, recover the ethanol until it has no alcohol smell, and continue to concentrate until the specific gravity is 1.05-1.10 clear ointment, add 133g of sucrose, 2g of sod...

Embodiment 3

[0066] Embodiment three (preparation of decoction)

[0067] Take 300g Acanthopanax and 150g Jujube Seed, add water to decoct twice, add 10 times the amount of water for the first time and decoct for 1.5 hours, filter the decoction, put the filtrate in a clean container, and set aside; add 8 times the amount of water to the filter residue, decoct After 1 hour, filter the decoction, combine the filtrate with the filtrate from the first decoction and then concentrate to a thick paste with a specific gravity of 1.20-1.25. While stirring, add the thick paste to the ethanol prepared in advance to make the ethanol When the content reaches 80%, refrigerate for 24 hours, take the supernatant, recover ethanol until there is no alcohol smell, and continue to concentrate to a thick paste with a specific gravity of 1.20-1.25, add 250g of honey, 200g of sugar, add water to 1000ml, and fill it. Sterilized, packaged, ready to serve.

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Abstract

The invention relates to an acanthopanax-spina date seed oral preparation with calming and tranquilizing effects and a preparation method thereof. The acanthopanax-spina date seed oral preparation is prepared by taking spina date seeds with calming and tranquilizing effects as a monarch drug and acanthopanax with the effects of tonifying kidney and spleen, reinforcing intelligence and tranquilizing as a ministerial drug and adopting a scientific processing method. The preparation method comprises the following steps: taking the acanthopanax and spina date seeds, adding water and decocting, removing alcohol insoluble solids by adopting an alcohol precipitation method, adding a right amount of flavoring agent and a right amount of preservative, adding water to a certain amount, uniformly stirring, filtering, filling and sterilizing, so that the acanthopanax-spina date seed oral preparation is obtained.

Description

technical field [0001] The invention belongs to the field of health food development, and in particular relates to an oral preparation of Acanthopanax spinosa jujube kernel with sedative and tranquilizing effects and a preparation method thereof. Background technique [0002] Insomnia is common in today's society. Insomnia not only affects people's rest at night, but also affects their work and life during the day. Long-term insomnia can also easily cause mental symptoms such as anxiety, irritability, and depression. Many insomniacs take barbiturates and benzodiazepines. Long-term use of these drugs can produce many side effects, such as anxiety, fear, delusions, hallucinations, and convulsions. The side effects of traditional Chinese medicine for treating insomnia are small and non-addictive, so it is a new direction for the study of sedative and hypnotic drugs. [0003] Suanzaoren, also known as jujube kernel, jujube seed, and wild jujube kernel. It is made by removing ...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61P25/20A23L33/105A23L21/10A23F3/14
CPCA23F3/14A23L21/10A23L33/105A23V2002/00A61K36/254A61K36/725A61K2236/331A61K2236/39A61K2300/00A23V2200/31A23V2250/21
Inventor 武璟琪刘士彤腾霞
Owner 哈尔滨宏琪生物科技有限公司
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