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Dual mode ionization device

An ionization mode, electrospray ionization technology, applied in the field of ion source, can solve problems such as rebound and droplet impact

Inactive Publication Date: 2017-10-31
WATERS TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the exact mechanism of ionization in impact spray technology is not fully understood, it is believed that the basic feature is that droplets impinge and bounce off charged surfaces

Method used

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  • Dual mode ionization device
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Examples

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Embodiment Construction

[0109] figure 1 Examples of the present invention are shown. The instrument comprises a source 2 of a sample to be analyzed, a liquid chromatographic separator 3 , a nebulizer 4 such as a pneumatically assisted nebulizer, a mass spectrometer 6 and an interface 8 for interfacing the nebulizer 4 with the mass spectrometer 6 . Such as figure 1 As shown, the atomizer 4 can be grounded at the reference potential. A translator mechanism may be provided for translating the atomizer between different spray positions or spray angles. A spray director 7 may be provided for altering the path along which the spray 32 from the atomizer 4 travels.

[0110] The interface 8 comprises an interface cone 10 connected to a power supply 12 for supplying a voltage to the interface cone 10 . The interface 8 also includes an ion guide 14 for guiding ions from the interface cone 10 into the spectrometer 6 .

[0111] The spectrometer 6 includes a first vacuum chamber 16 maintained at a first press...

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Abstract

An ion source is disclosed that alternates between ionizing analytes in a sample by electrospray ionization and impact ionization.

Description

technical field [0001] The present invention relates to ion sources for mass and / or ion mobility spectrometers. In particular, the invention relates to ion sources operable in two ionization modes. Background technique [0002] An atmospheric pressure ionization ("API") ion source is typically used to ionize the liquid stream from an HPLC or UPLC chromatography device before analyzing the resulting gas phase ions by mass spectrometry. The two most commonly used techniques include electrospray ionization ("ESI") and atmospheric pressure chemical ionization ("APCI"). In the ESI technique, a nebulizer converts a liquid sample stream into a spray of charged droplets in the presence of an electric field. When these droplets evaporate, they generate analyte ions. [0003] It is also known to ionize analytes by impingement spray techniques. According to this technique, a nebulizer converts a liquid sample stream into a spray of liquid droplets. These droplets are then directed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/26H01J49/10
CPCH01J49/10H01J49/26H01J49/107H01J49/16H01J49/165H01J49/0445G01N30/724G01N30/7266H01J49/34
Inventor 约瑟夫·A·贾雷尔
Owner WATERS TECH CORP
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