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Method for extracting and separating alkaloid by utilizing ionic liquid and inorganic salt mixed extracting agent

A technology of mixed extractant and ionic liquid, which is applied in the field of extraction and separation of alkaloids by using a mixed extractant of ionic liquid and inorganic salt, which can solve the problems of difficult operation and complicated process, and achieve the effects of easy recovery, high boiling point and good solubility

Inactive Publication Date: 2017-11-07
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN101695518A discloses a method for extracting total alkaloids of Phytophthora fruticosa, separating palmatine and jatrorrhizine. The method needs to add deionized water, and obtain total alkaloids of Phytophthora fructus vine by elution, concentration, and evaporation. complex, difficult to operate
[0005] Chinese patent CN102631414A discloses the extraction and purification process of the total alkaloids of the terrestrial complex. Three steps of extraction, separation and purification are used to obtain the total alkaloids of the teratinous compound, and the resin is used for adsorption. The process is complicated

Method used

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  • Method for extracting and separating alkaloid by utilizing ionic liquid and inorganic salt mixed extracting agent

Examples

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Embodiment 1

[0034] A method for extracting and separating alkaloids by using an ionic liquid and an inorganic salt mixed extractant, the operation steps are as follows:

[0035] (1) Preparation of mixed extractant: 2g of inorganic salt and 20g of 1-butyl-3-methylimidazolidine sulfonamide salt ([Bmim][Ace]) were fully mixed at 25°C to prepare a mixed extractant ;

[0036] (2) Alkaloids in raw materials: Fully mix 20 g of the mixed extractant obtained in step (1) with 100 g of raw materials, heat to 80° C., stir for 40 min at a speed of 500 r / min, leave it to stand after stirring, and cool to At room temperature, the extract phase is taken out to obtain alkaloids with a content as high as 95%.

Embodiment 2

[0038] A method for extracting and separating alkaloids by using an ionic liquid and an inorganic salt mixed extractant, the operation steps are as follows:

[0039] (1) Preparation of mixed extractant: Mix 1 g of inorganic salt with 50 g of 1-butyl-3-methylimidazolium chloride ([Bmim][Cl]) at 25° C. to prepare mixed extractant;

[0040] (2) Alkaloids in the raw materials: fully mix 50 g of the mixed extractant obtained in step (1) with 150 g of raw materials, heat to 85° C., stir for 50 min at a speed of 700 r / min, let stand and cool to At room temperature, the extract phase is taken out to obtain alkaloids with a content as high as 94%.

Embodiment 3

[0042] A method for extracting and separating alkaloids by using an ionic liquid and an inorganic salt mixed extractant, the operation steps are as follows:

[0043] (1) Preparation of mixed extractant: 1.5g of inorganic salt and 30g of 1-butyl-3-methylimidazolium bromide ([Bmim][Br]) were fully mixed at 25°C to prepare a mixed extractant;

[0044] (2) Alkaloids in the raw materials: fully mix 30 g of the mixed extractant obtained in step (1) with 200 g of raw materials, heat to 90° C., stir for 70 min at a speed of 800 r / min, let stand and cool to At room temperature, the extract phase is taken out to obtain alkaloids with a content as high as 97%.

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Abstract

The invention relates to a method for extracting and separating alkaloid by utilizing an ionic liquid and inorganic salt mixed extracting agent. The method takes the ionic liquid and inorganic salt mixed extracting agent as an extracting agent, and ionic liquid has extremely low steam pressure, has a wide liquid-state range and high stability, and is easy to recycle; an ionic liquid structure can be designed according to different requirements, and novel ionic liquid with different functions is synthesized. In an extraction and separation process, the ionic liquid with different types is selected or synthesized according to different separation systems and can be efficiently separated. The ionic liquid and inorganic salt mixed extracting agent is used as the extracting agent so that the selectivity of the ionic liquid can be improved and the viscosity of the ionic liquid can be reduced, and the separation efficiency is easy to improve. According to the method provided by the invention, the ionic liquid and inorganic salt mixed extracting agent is used for extracting and separating the alkaloid, and an application range of the ionic liquid is expanded; a novel method for separating the alkaloid is improved, the content of the obtained alkaloid is high, and the ionic liquid has little dosage and can be circularly utilized.

Description

【Technical field】 [0001] The invention belongs to the field of separation and purification in the chemical industry, and in particular relates to a method for extracting and separating alkaloids by using a mixed extraction agent of ionic liquid and inorganic salt. 【Background technique】 [0002] Alkaloids are organic compounds containing nitrogenous bases that can react with acids to form salts. They are widely present in living organisms (mainly plants) and have strong physiological effects on humans and animals. Most of the molecular structures of alkaloids belong to secondary amines, tertiary amines or quaternary amines, and a few are primary amines. They often contain heterocyclic rings in their structure, and the nitrogen atom is in the ring. Although the content of alkaloids in plants is small, they are closely related to humans. Many alkaloids are good medicines for curing diseases. For example, berberine in the rhizome of Coptis chinensis of Ranunculaceae is the ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/02A61K36/899A61K36/67A61K36/81
CPCA61K36/899B01D11/0257B01D11/0288A61K36/67A61K36/81
Inventor 王英龙许希彩文桂林于萌潇朱兆友
Owner QINGDAO UNIV OF SCI & TECH
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