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Safe preparation method for adamantanol and device

A technology for adamantanol and a preparation device is applied in the preparation of organic compounds, chemical instruments and methods, preparation of aminohydroxy compounds, etc., and can solve the problems of safety accidents and high production costs

Inactive Publication Date: 2017-11-07
四川众邦新材料股份有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0007] The invention provides a safe preparation method and device of adamantanol, which solves the technical problems of the prior art that the mixed acid nitration reaction is prone to safety accidents and high production cost in the production of adamantanol

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  • Safe preparation method for adamantanol and device
  • Safe preparation method for adamantanol and device

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Embodiment Construction

[0020] In order to make the above objects, features and advantages of the present invention more clearly understood, the present invention will be described in further detail below with reference to the accompanying drawings and specific embodiments.

[0021] like figure 1 Shown, is a kind of safe preparation method of adamantanol, comprising:

[0022] Step 101, mixing and dispersing the reaction raw materials and the concentrated sulfuric acid;

[0023] Wherein, the reaction raw material is amantadine or amantadine hydrochloride or amantadine sulfate, and the molar ratio of the reaction raw material and concentrated sulfuric acid is 1:3~1:5;

[0024] Step 102, using a magnetic pump to pump the mixed solution of the reaction raw materials and the concentrated sulfuric acid and the concentrated nitric acid into the mixer;

[0025] Wherein, the molar ratio of the concentrated nitric acid to the concentrated sulfuric acid is 0.08:1 to 0.15:1;

[0026] Step 103, using a magneti...

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Abstract

The invention relates to the field of drug synthesis and discloses a safe preparation method for adamantanol and a device. The method comprises the following steps: mixing and dispersing reaction raw materials and concentrated sulfuric acid; utilizing a magnetic pump to pump a mixed solution of the reaction raw materials and concentrated sulfuric acid and the concentrated nitric acid into a mixer; utilizing the magnetic pump to pump the mixed solution in the mixer into a tubular reactor; collecting the reaction liquor discharged from the tubular reactor and performing hydrolysis reaction; and separating and extracting the reaction liquor and treating the wastewater, thereby acquiring 3-amino-1-adamantanol. The invention has the advantages that few impurities are generated, the yield of target products is high, the reaction process is safe, the wastewater contains few impurities and the wastewater treating cost is greatly lowered.

Description

technical field [0001] The invention relates to the field of drug synthesis, in particular to a method and device for the safe preparation of adamantanol. Background technique [0002] 3-Amino-1-adamantanol is an intermediate for the preparation of various drugs such as drugs for the treatment of diabetes. The existing technical process for producing 3-amino-1-adamantanol at home and abroad is usually the use of amantadine or its salt ( Amantadine hydrochloride, amantadine sulfate, etc.) as starting materials, after nitration reaction, hydrolysis, separation and purification in sulfuric acid-nitric acid mixed acid, the crystal of the target product 3-amino-1-adamantanol is obtained . In this production and preparation process, the nitration reaction of the starting materials in the mixed acid is the basis for realizing the technical goals of the process, which directly affects the success or failure of the process technology and the production cost. [0003] The mixed acid...

Claims

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Application Information

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IPC IPC(8): C07C215/44C07C213/00
CPCC07C213/00C07C215/44
Inventor 王南陈小东杨友国李超张鸿
Owner 四川众邦新材料股份有限公司
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