Preparation method of polypeptide growth factor modified hair-based material

A technology of peptide growth factors and base materials, which is applied in the field of preparation of peptide growth factor-modified hair-based materials, can solve problems such as the inability to directly use hair peptide growth factors, and achieve good wide application, convenient material acquisition, and good biocompatibility Effect

Active Publication Date: 2017-11-14
北京智枢生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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  • Preparation method of polypeptide growth factor modified hair-based material
  • Preparation method of polypeptide growth factor modified hair-based material
  • Preparation method of polypeptide growth factor modified hair-based material

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Embodiment 1

[0035] Example 1, preparation of polypeptide growth factor modified hair-based material

[0036] 1. Preparation method

[0037] Prepare the polypeptide growth factor modified hair-based material according to the following steps:

[0038] (1) Preparation of hair-based material treated with hydrochloric acid

[0039] Take hair with a length of 1cm (scanning electron microscope photo as figure 1 As shown in A), several roots were soaked in an aqueous solution of 75wt% alcohol for 60 minutes at a temperature of 37°C, washed with distilled water and dried at a temperature of 37°C for 15 minutes. Then 8 mg of hair is placed in 10 mL of hydrochloric acid aqueous solution with a mass concentration of 10%, and soaked for 10 min at 37° C.; after the reaction is completed, it is rinsed with distilled water and freeze-dried for 36 h to obtain the hair-based material (scanning electron microscope photo as shown in figure 1 shown in B).

[0040] (2) Preparation of NGF-modified hair-base...

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Abstract

The invention discloses a preparation method of a polypeptide growth factor modified hair-based material. The method comprises the following steps of (1), placing hair into an aqueous solution of ethyl alcohol, soaking, taking out the hair, and carrying out washing and drying; placing the dried hair in an aqueous solution of an acid, soaking, taking out the hair, and carrying out the washing and the drying, so as to obtain a hair-based material; (2), under the action of an initiator, enabling the hair-based material obtained in the step (1) and a polypeptide nerve growth factor to react in water, so as to obtain the polypeptide growth factor modified hair-based material. According to the method provided by the invention, surface treatment is carried out on the surface of the hair by utilizing the mild corrosive action of a dilute acid; a carboxyl group is exposed to the surface of the hair; multiple polypeptide factors are grafted conveniently. A hair material, serving as an autologous appendant organ, is conveniently taken. The hair-based material is used for providing supporting action for the polypeptide growth factor; the polypeptide growth factor is released; the polypeptide growth factor needed in an overall regeneration process is provided for defective tissue.

Description

technical field [0001] The invention relates to the field of bioengineering, in particular to a method for preparing hair-based materials modified by polypeptide growth factors. Background technique [0002] Polypeptide growth factors can be produced by many cells in the body and have important physiological, pathological and therapeutic effects. For example, it participates in the regulation of immune response and inflammatory response; the combination with cell surface receptors eventually leads to changes in the synthesis of RNA and protein in cells, thereby affecting cell behavior; regeneration after embryogenesis, development, differentiation, and various human tissue injuries important role in the restoration process. Various factors produce synergistic, additive or antagonistic effects on cell functions through mutual induction and cross-regulation. The half-life of polypeptide factors in the body is extremely short, so they need to be loaded onto biological materia...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/54
Inventor 李晓光付轩杨朝阳高钰丹
Owner 北京智枢生物科技有限公司
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