The invention discloses a preparation method of a polypeptide
growth factor modified hair-based material. The method comprises the following steps of (1), placing hair into an
aqueous solution of ethyl
alcohol, soaking, taking out the hair, and carrying out washing and
drying; placing the dried hair in an
aqueous solution of an acid, soaking, taking out the hair, and carrying out the washing and the
drying, so as to obtain a hair-based material; (2), under the action of an initiator, enabling the hair-based material obtained in the step (1) and a polypeptide
nerve growth factor to react in water, so as to obtain the polypeptide
growth factor modified hair-based material. According to the method provided by the invention, surface treatment is carried out on the surface of the hair by utilizing the mild corrosive action of a
dilute acid; a carboxyl group is exposed to the surface of the hair; multiple polypeptide factors are grafted conveniently. A
hair material, serving as an autologous appendant organ, is conveniently taken. The hair-based material is used for providing supporting action for the polypeptide
growth factor; the polypeptide growth factor is released; the polypeptide growth factor needed in an overall regeneration process is provided for defective tissue.