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Calcium tablet containing vitamin K2 and preparation method thereof

A technology of vitamins and calcium tablets, applied to medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulas, etc., can solve problems such as poor activity, low utilization rate of organic calcium, and unfavorable calcium absorption. Fast absorption, low cost, and the effect of promoting absorption

Active Publication Date: 2020-06-09
富诺健康股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The Chinese patent with the publication number CN101244081A discloses a bone-nourishing calcium tablet, which mainly consists of 6-12 parts of enzymatically hydrolyzed complex calcium, 10-16 parts of biological calcium carbonate, 3-6 parts of calcium gluconate, and 0.08-0.25 parts of vitamin D. 0.08 to 0.25 parts of vitamin K and 42 parts of whole milk powder. This invention solves the technical problem of calcium tablets that promote calcium absorption. Although the compound calcium supplement enhances the absorption of calcium, the utilization rate of organic calcium is low. , poor activity
[0005] The Chinese patent with the publication number CN101537174A discloses a health-preserving calcium, which mainly consists of the following formula by weight: 3-13 parts of enzymatically hydrolyzed complexed calcium bone powder, 6-16 parts of collagen powder, 1.5-4 parts of vitamin C, Tianmen 12-23 parts of calcium aspartate, 0.5-1 part of magnesium stearate, 7-17 parts of bovine colostrum powder, 15-25 parts of xylitol, 15-25 parts of sea buckthorn and trace amounts of vitamin D3 and vitamin K3; The compound calcium agent used in the invention, but the calcium source compound in this invention is stable, which is not conducive to the absorption of calcium

Method used

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  • Calcium tablet containing vitamin K2 and preparation method thereof
  • Calcium tablet containing vitamin K2 and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 A kind of calcium tablet containing vitamin K2

[0027] The calcium tablet containing vitamin K2 is composed of the following ingredients and parts by weight: 50 parts of calcium carbonate, 0.8 parts of vitamin D, 25.5 parts of vitamin K, 2.5 parts of inclusion agent, 3 parts of absorption accelerator, 25 parts of maltodextrin, carboxylate 3 parts of sodium methylcellulose and 2 parts of water;

[0028] The inclusion agent is composed of polyethylene glycol fatty acid glyceride, carboxymethyl-β-cyclodextrin and polyethylene glycol-b-polycaprolactone in a weight ratio of 5:2:1;

[0029] The absorption-promoting agent is composed of chitosan, lauryl maltoside and rhamnolipid in a weight ratio of 9:3:1.

[0030] The preparation method of the calcium tablet containing vitamin K2 is that the steps are:

[0031] S1: Mix vitamin D, vitamin K2 and inclusion agent, stir evenly, and let stand for 13 hours to obtain viscous substance A;

[0032] S2: uniformly mix t...

Embodiment 2

[0034] Embodiment 2 A kind of calcium tablet containing vitamin K2

[0035] The calcium tablet containing vitamin K2 is composed of the following components and parts by weight: 40 parts of calcium carbonate, 1 part of vitamin D, 25 parts of vitamin K, 3 parts of inclusion agent, 2 parts of absorption enhancer, 30 parts of maltodextrin, carboxymethyl 2 parts sodium cellulose and 3 parts water;

[0036] The inclusion agent is composed of polyethylene glycol fatty acid glyceride, carboxymethyl-β-cyclodextrin and polyethylene glycol-b-polycaprolactone in a weight ratio of 4:1:1;

[0037] The absorption-promoting agent is composed of chitosan, dodecyl maltoside and rhamnolipid in a weight ratio of 10:4:1.

[0038] The preparation method of the calcium tablet containing vitamin K2 is similar to Example 1.

Embodiment 3

[0039] Embodiment 3 A kind of calcium tablet containing vitamin K2

[0040] The calcium tablet containing vitamin K2 is composed of the following components and parts by weight: 60 parts of calcium carbonate, 0.5 parts of vitamin D, 26 parts of vitamin K, 2 parts of inclusion agent, 4 parts of absorption-promoting agent, 20 parts of maltodextrin, carboxymethyl 4 parts sodium cellulose and 1 part water;

[0041] The inclusion agent is composed of polyethylene glycol fatty acid glyceride, carboxymethyl-β-cyclodextrin and polyethylene glycol-b-polycaprolactone in a weight ratio of 6:3:1;

[0042] The absorption-promoting agent is composed of chitosan, lauryl maltoside and rhamnolipid in a weight ratio of 8:2:1.

[0043] The preparation method of the calcium tablet containing vitamin K2 is similar to Example 1.

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Abstract

The invention belongs to the technical field of healthcare products and specifically relates to a calcium tablet containing vitamin K2 and a preparation method thereof. The calcium tablet comprises the following components in parts by weight: 40-60 parts of calcium carbonate, 0.5-1 part of vitamin D, 5-6 parts of vitamin K2, 2-3 parts of inclusion agent, 2-4 parts of absorption promoter, 20-30 parts of maltodextrin, 2-4 parts of sodium carboxymethylcellulose and 1-3 parts of water. The calcium tablet disclosed by the invention is capable of promoting the calcium absorption and conversion, has an excellent calcium-supplementing effect and is capable of reducing constipation caused by the calcium source of calcium carbonate.

Description

technical field [0001] The invention belongs to the technical field of health products, and in particular relates to a calcium tablet containing vitamin K2 and a preparation method thereof. Background technique [0002] The human body reaches the highest bone mass obtained in its lifetime at the age of 30-35, and then gradually decreases. After the age of 40 for women, and for men after 60, they enter a period of rapid bone loss. The net loss of bone mass leads to the loss of minerals in the bones The reduction of matter and organic matter makes the bone tissue thinner, fractured and porous, the brittleness of the bone increases, and the resistance to stress decreases, resulting in osteoporosis symptoms such as low back pain, leg cramps, and walking fatigue. [0003] As an important calcium-regulating hormone in the human body, vitamin D is beneficial to increase the active absorption of calcium in the intestine and the reabsorption of calcium in the kidney, thereby increasi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K33/10A61K47/69A61K47/36A61K47/26A61P3/02A61K31/59A61K31/122
CPCA61K9/2018A61K9/205A61K31/122A61K31/59A61K33/10A61K2300/00
Inventor 程彦
Owner 富诺健康股份有限公司
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