Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of preparation method of cosmetic implant

A technology of implants and lactide, which can be used in pharmaceutical formulations, prostheses, and capsule delivery to solve problems such as uneven filling, facial stiffness, and dependence

Active Publication Date: 2020-05-22
BEIJING HOTWIRE MEDICAL TECH DEV CO LTD
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the best way to solve such problems clinically is to inject subcutaneous fillers to prop up the loose skin and improve it. The main raw materials of such products on the market are hyaluronic acid, collagen, etc., but hyaluronic acid is due to the processing method. The problem is that the user will experience facial stiffness after repeated use, and with the increase in the number of injections, the tolerance of the body will become more obvious, and the phenomenon of dependence will increase, and the frequency of injections will increase; and collagen due to its natural defects, degradation speed Faster, and prone to uneven filling, increasing the economic pressure of users and the difficulty of operation for clinicians

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 20.0g of DL-lactide and dissolve it in 1000ml of 50% ethanol solution;

[0024] Measure 1000ml of purified water, adjust the pH to 5 with 1.0mol / L hydrochloric acid solution, mix type I and type III collagen at a dry weight ratio of 1:3, weigh 3.0g of the mixture and disperse it into the solution, fully dissolve and filter with a 200nm filter ;

[0025] Measure 1000ml of purified water, adjust the pH to 5 with 1.0mol / L hydrochloric acid solution, weigh 2.0g of polyglutamic acid and disperse it into the solution, fully dissolve and filter with a 200nm filter membrane;

[0026] Take 50ml of the above-mentioned collagen solution and drip it into 500mlDL-lactide ethanol solution at a speed of 20ml / min, emulsify, add the stirring speed at 600 rpm, the line speed of the shearing machine is 20m / s, and the number of times of shearing is 3 times. Collagen nanoparticles were obtained by filtering with a 200nm filter membrane;

[0027] Get 50ml of the above-mentioned polyg...

Embodiment 2

[0032] Weigh 20.0g of DL-lactide and dissolve it in 1000ml80% ethanol solution;

[0033] Measure 1000ml of purified water, adjust the pH to 7 with 0.2mol / L sodium hydroxide acid solution, mix type I and type III collagen at a dry weight ratio of 1:3, weigh 3.0g of the mixture and disperse it into the solution, and dissolve it fully at 500nm Membrane filtration;

[0034] Measure 1000ml of purified water, adjust the pH to 7 with 0.2mol / L sodium hydroxide acid solution, weigh 2.0g of polyglutamic acid and disperse it into the solution, fully dissolve and filter with a 200nm filter membrane;

[0035] Take 50ml of the above-mentioned collagen solution and drip it into 500mlDL-lactide ethanol solution at a speed of 500ml / min, emulsify, add the stirring speed at 600 rpm, the linear speed of the shearing machine is 20m / s, and the number of times of shearing is 3 times. Collagen nanoparticles were obtained by filtering with a 200nm filter membrane;

[0036] Get the above-mentioned po...

Embodiment 3

[0041] Weigh 50.0g of DL-lactide and dissolve it in 1000ml100% ethanol solution;

[0042] Measure 1000ml of purified water, adjust the pH to 5 with 1.0mol / L malic acid solution, mix type I and type III collagen at a dry weight ratio of 1:3, weigh 3.0g of the mixture and disperse it into the solution, and filter it through a 200nm membrane after fully dissolving filter;

[0043] Measure 1000ml of purified water, adjust the pH to 5 with 1.0mol / L malic acid solution, weigh 2.0g of polyglutamic acid and disperse it into the solution, fully dissolve and filter with a 200nm filter membrane;

[0044] Take 50ml of the above-mentioned collagen solution and drop it into 500mlDL-lactide ethanol solution at a speed of 20ml / min, emulsify, add the stirring speed at 600 rpm, the line speed of the shearing machine is 20m / s, and the number of times of shearing is 3 times. Collagen nanoparticles were obtained by filtering with a 200nm filter membrane;

[0045] Take 50ml of the above polygluta...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method for a cosmetic implant. The method comprises the following steps: dissolving DL-lactide in an ethyl alcohol solution; respectively preparing collagen and polyglutamic acid into a 0.01-5% (W / V) disperse system; filtering by adopting a 50-500nm filtering film; respectively dropping the acquired filtrate into a DL-lactide ethanol solution and emulsifying; adopting the 50-500nm filtering film for filtering the emulsified solution, thereby acquiring nanometer collagen particles and nanometer polyglutamic acid particles; and mixing the two at a certain ratio, dispersing into a phosphate disperse system and preparing into a suspension, thereby acquiring the cosmetic implant. The cosmetic implant prepared according to the preparation method for the cosmetic implant provided by the invention has excellent supporting property, is capable of effectively slow controlling the release of moisturizing and repairing components, is long in holding time after implanting and filling and is free of an additive.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, the industry of sterile implantable medical devices, clinical microplastic surgery, and is mostly used for human subcutaneous filling, assisting tissue repair and improving aging phenomena such as skin relaxation, and particularly relates to a preparation method of cosmetic implants . Background technique [0002] Micro-plastic surgery is widely used to improve human body appearance, among them, natural human aging phenomena such as skin sagging and wrinkles, which are less traumatic, have attracted more attention from beauty lovers. At present, the best way to solve such problems clinically is to inject subcutaneous fillers to prop up the loose skin and improve it. The main raw materials of such products on the market are hyaluronic acid, collagen, etc., but hyaluronic acid is due to the processing method. The problem is that the user will experience facial stiffness after repeated...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/50A61L27/54
CPCA61L27/26A61L27/50A61L27/54A61L2300/412A61L2300/602A61L2300/624A61L2400/06A61L2400/12C08L77/04C08L89/00
Inventor 张春红富勇
Owner BEIJING HOTWIRE MEDICAL TECH DEV CO LTD