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Application of polygala tenuifolia seedling extract in preparation of anti-dementia medicament or healthcare product

A technology of extracts and health products, applied in the field of traditional Chinese medicine

Pending Publication Date: 2017-12-15
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, it is characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, visual-spatial skill impairment, executive dysfunction, and personality and behavior changes. Modern medicine still lacks effective prevention and treatment methods for AD.

Method used

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  • Application of polygala tenuifolia seedling extract in preparation of anti-dementia medicament or healthcare product
  • Application of polygala tenuifolia seedling extract in preparation of anti-dementia medicament or healthcare product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Extraction method has ultrasonic extraction method, heating reflux method, dipping method etc., and contriver has selected simple and fast ultrasonic extraction method, after drying and pulverizing Polygala seedlings, extract with 50% ethanol of 10 times of volume, investigated extraction time (20 minutes , 30 minutes, 40 minutes) and the number of extractions (1 time, 2 times) on the extraction rate. The results showed that when the number of extractions was 1 time, the extraction rates of the extraction time (20 minutes, 30 minutes, 40 minutes) were 15.2%, 17.5%, 19.4% respectively; 30 minutes, 40 minutes) extraction rate: 21.6%, 23.5%, 25.1%. Combined with the process cost, the final optimal conditions are: extraction twice, and the extraction time is 40 minutes. A preferred example is as follows: 10 kg of Polygala seedlings are dried and crushed, then ultrasonically extracted with 10 times the volume of 50% ethanol, extracted twice for 40 minutes each time, the sol...

Embodiment 2

[0016] In order to verify the anti-dementia effect of polygala seedling extract, the inventor conducted a pharmacodynamic experiment using a model of learning and memory impairment in mice induced by scopolamine. The test conditions are as follows:

[0017] 1. Experimental drug

experiment example 1

[0018] Experimental Example 1 Prepare Polygala seedling extract, Piracetam Tablets (Yichang Renfu Pharmaceutical Co., Ltd., batch number: 2160402), and Scopolamine Hydrobromide Injection (produced by Suicheng Pharmaceutical Co., Ltd., batch number: 1601211).

[0019] 2. Main experimental instruments and reagents

[0020] Morris water maze experimental device (model ZS-001 Morris, manufacturer: Beijing Zhongshi Dichuang Technology Development Co., Ltd.), electronic analytical balance (FA2004 220V 50HZ Shanghai Liangping Instrument Co., Ltd.), purified water, saline.

[0021] 3. Experimental animals

[0022] Male Kunming mice, weighing 20-25 g, were provided by the Experimental Animal Center of Xi'an Jiaotong University School of Medicine.

[0023] 4. Experimental grouping and drug administration method

[0024] The mice were randomly divided into 4 groups, 10 in each group: the positive group was fed with 750 mg / kg of

[0025] For piracetam, the treatment group was administe...

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Abstract

The invention discloses application of a polygala tenuifolia seedling extract in preparation of an anti-dementia medicament or healthcare product. The polygala tenuifolia seedling extract is prepared with a preparation method which comprises the following steps: drying and crushing polygala tenuifolia seedlings; performing ultrasonic extracting by using 20 to 70 percent ethyl alcohol with the volume of 5 to 10 times of that of the polygala tenuifolia seedlings; extracting 1 to 2 times, and extracting for 20 to 40 minutes each time; recycling a dissolvent; concentrating under reduced pressure; performing vacuum drying to obtain the polygala tenuifolia seedling extract.

Description

technical field [0001] The invention relates to the application of polygala seedling extract in the preparation of anti-dementia medicine or health care product, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Polygala seedlings, also known as small grass, fine grass, and green grass, are Polygala plants of the Polygalaceae family. Polygala tenuifolia The above-ground part of Willd., some areas also include Polygala ovale P. sibirica The aerial part of L. can only be used in folks, or circulated in Chinese herbal medicine markets in Zhejiang, Hebei, Jiangsu and Shanghai. Polygala is Polygala polygala Polygala tenuifolia Willd. or Polygala ovale P. sibirica The dried roots of L., included in the previous editions of the "Chinese Pharmacopoeia", are legally certified authentic Polygala medicinal materials in the national Chinese medicinal material market, and are also legal raw materials for processing Polygala deco...

Claims

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Application Information

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IPC IPC(8): A61K36/69A61P25/28
CPCA61K36/69A61K2236/333
Inventor 房敏峰张典张丹婷李忠虎宋炜豪蔡成菲尚姣
Owner NORTHWEST UNIV
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