Device and method for increasing expression of neurotrophic factors by using cranium ultrasonic stimulation

A neurotrophic factor and ultrasound technology, applied in ultrasound therapy, treatment, etc., can solve problems such as hindering BDNF, weakening the therapeutic effect, and affecting the effectiveness of BDNF levels

Inactive Publication Date: 2017-12-26
SHANGHAI JIAO TONG UNIV
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Problems solved by technology

At present, drug therapy is mainly used to increase the level of BDNF in the central system, but the complete brain-blood barrier prevents BDNF from entering the brain tissue as a mature protein, thereby weakening the therapeutic effect
It is also difficult for the existing neuromodulation technology to accurately directly stimulate the hippocampus located in the deep brain area, thus affecting its effectiveness in increasing the level of BDNF

Method used

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  • Device and method for increasing expression of neurotrophic factors by using cranium ultrasonic stimulation
  • Device and method for increasing expression of neurotrophic factors by using cranium ultrasonic stimulation
  • Device and method for increasing expression of neurotrophic factors by using cranium ultrasonic stimulation

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Embodiment Construction

[0027] The implementation of the present invention is described below through specific examples and in conjunction with the accompanying drawings, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific examples, and various modifications and changes can be made to the details in this specification based on different viewpoints and applications without departing from the spirit of the present invention.

[0028] figure 1 It is a system structure diagram of a device for increasing the expression of neurotrophic factors by transcranial ultrasound stimulation of the present invention, figure 2 It is a schematic diagram of ultrasonic parameters in a specific embodiment of the present invention. Such as figure 1 and figure 2 As shown, the present invention is a system for increasing the expr...

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Abstract

The invention discloses a device and method for increasing expression of neurotrophic factors by using cranium ultrasonic stimulation. The device comprises a first signal generator, a second signal generator, a power amplifier and an ultrasonic transducer, wherein the first signal generator is used for generating preset signals of square waveform parameters, the second signal generator is used for generating preset pulse signals of sine waveform parameters under triggering of square waves output by the first signal generator, the power amplifier is used for conducting power amplification on the pulse signals generated by the second signal generator and stimulating the ultrasonic transducer to generate ultrasonic stimulation waves, and the ultrasonic transducer is used for receiving signals output by the power amplifier, transforming the generated ultrasonic stimulation waves and achieving ultrasonic stimulation for the brain area. The device and method for increasing the expression of neurotrophic factors by using the cranium ultrasonic stimulation increase the BDNF expression level of the hippocampus by stimulating prefrontal lobes, and provide approaches for treatment of multiple neurodegeneration diseases.

Description

technical field [0001] The present invention relates to the technical field of transcranial ultrasonic stimulation of nerve regulation, in particular to a device and method for increasing the expression of neurotrophic factors (Brain Derived Neurotrophic Factor, brain-derived neurotrophic factor) by transcranial ultrasonic stimulation. Background technique [0002] Transcranial ultrasound stimulation, as an emerging brain function regulation technology, is non-invasive, high spatial resolution, penetrating and The advantages of high depth and easy combination with other technologies can target specific functional areas, so it has attracted the attention of many researchers, and its application prospects are widely optimistic. In recent years, significant progress has been made in the research field of ultrasonic stimulation technology. Experiments have proved that transcranial ultrasonic stimulation can not only induce or inhibit neural electrical activity, but also increase...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N7/00
CPCA61N7/00A61N2007/0026
Inventor 张大曲孙俊峰李航道童善保
Owner SHANGHAI JIAO TONG UNIV
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