Microchannel and manufacture method thereof

A technology of microchannel and plane expansion, applied in chemical instruments and methods, laboratory utensils, laboratory containers, etc., can solve the problem of inability to have the same surface modification in the cross section, inability to perform partial surface modification in the exposure section, and inability to realize microchannels. Surface modification, etc.

Active Publication Date: 2017-12-29
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] And the method that surface modification is carried out to the inner wall of microchannel generally has following several: one, inject chemical reagent in microchannel, carry out surface modification by the chemical reaction of reagent and surface, but this method can't realize the local surface modification in microchannel
2. Use photosensitive polymer combined with mask exposure for surface modification. This method can perform local surface modification at the designated position of the microchannel, but all surfaces of the exposed section will have the same surface modification, that is, localized surface modification cannot be performed on the exposed section. Surface Modification
3. Before the bonding of the microchannel, the bottom or top surface of the channel is first partially modified, and then bonded to obtain a complete microchannel. This method can only be used for surface modification on the bottom or top surface, but it cannot modify the channel. surface finish on the side walls of the
[0005] Therefore, it is a great challenge to achieve high-resolution 3D patterned surface modification on the inner walls of microchannels, especially for different surface modifications on the inner walls of polygonal cross-sections.

Method used

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  • Microchannel and manufacture method thereof
  • Microchannel and manufacture method thereof
  • Microchannel and manufacture method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0105] In this embodiment, a PDMS microchannel (100) with a square cross-section is fabricated using a planar folding technique. Among them, refer to Figure 2a , the microchannel is a square cross-section (10), and a hydrophilic coating (12) needs to be made locally on the inner wall surface (11); refer to Figure 2b , and the side length a of the microchannel is 1 mm, and the wall thickness h is 2 mm. The specific production process is as follows:

[0106] (1) Reference Figure 2c , the square section (10) of the microchannel (100) can be decomposed into an expanded figure (30) consisting of N=4 isosceles trapezoids (20); wherein, the upper base of the isosceles trapezoid a=1 mm, height For h=2 millimeters, base angle θ=(180°-360° / N) / 2=45°; the upper base of the isosceles trapezoid corresponds to the inner wall surface (11) of the microchannel, and the waist of the isosceles trapezoid corresponds to that of the folded microchannel Bonding surface (21).

[0107] (2) desi...

Embodiment 2

[0112] In this embodiment, a triangular section PDMS microchannel (200) is fabricated using planar folding technique. refer to Figure 3a , the microchannel is an equilateral triangle section (110), and the inner wall surface (111) is made with a metal film helical coil (112); the side length a of the microchannel is 1 millimeter, the wall thickness h is 2 millimeters, and the metal film substrate is 10 nanometers thick Chromium film, metal film surface layer is 50 nanometers thick gold film. The specific production process is as follows:

[0113] (1) Reference Figure 3b , the triangular section (110) is decomposed into a planar expansion figure (120) made of N=3 isosceles trapezoids (113), the upper base a=1 millimeter of the isosceles trapezoid (113), and the height is h=2 millimeters , base angle θ=(180–360 / N) / 2=30°.

[0114] (2) According to the planar expansion figure (120) design such as Figure 3c The mold (130) is cast as shown, and the mold (130) is made using 3...

Embodiment 3

[0120] In this embodiment, according to the method and conditions substantially the same as in Embodiment 2, a regular triangular cross-section (NOA) photosensitive resin microchannel was fabricated using planar folding technology. The difference is that in this example,

[0121] (a) Perform steps (1)-(2) of Example 2 to obtain a casting mold (130).

[0122] (b) Mix the NOA photosensitive resin prepolymer and the initiator evenly, pour the mixed solution into the mold (130) and degas it, then cure it under ultraviolet exposure, and cast to obtain the planar unfolded structure of the polymer.

[0123] (c) Coat the bonding surface with a resin adhesive, and fold and close the planar unfolded structure to obtain a microchannel with a regular triangular cross-section.

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Abstract

The invention provides a microchannel and a manufacture method thereof. The manufacture method of the microchannel comprises the following step: folding a plane development structure to obtain a microchannel, wherein the cross section of the microchannel is a regular polygon of which the number of sides is N, and the plane development structure comprises N substructures of which the cross sections are isosceles trapezoids. According to the manufacture method of the microchannel, which is provided by the invention, the obtained cross section shape of the microchannel can be polygonal such as triangular, quadrangular, pentagonal or hexagonal, so that the geometrical shape is richer; and the method can be used for carrying out multiple times or multiple types of local surface modification or local surface processing on the inner wall of the microchannel, i.e., the upper surface of the plane development structure, so that different surface pattern designs can be carried out on all surfaces of the inner wall of the microchannel, then the plane development structure can be folded and closed to form a polygonal microchannel of which the inner wall has three-dimensional patterning modification, and then the design of the microchannel which has a three-dimensional complex inner wall shape can be realized.

Description

technical field [0001] The invention relates to the technical field of microfluidic chip fabrication, and in particular, the invention relates to a microfluidic channel and a fabrication method thereof. Background technique [0002] Microfluidic chips are widely used in the fields of material synthesis, biochemical analysis, and biomedicine, among which microchannels are an important part of microfluidic chips. The surface wettability, surface coating, surface film deposition, surface roughness and surface structure of the inner wall of the microchannel all play an important role in the realization of the function of the microfluidic chip. For example, in the microfluidic chip for making emulsified droplets, wettability modification is required locally in the microchannel; for making oil-in-water emulsion droplets, it is necessary to carry out local hydrophilic modification at the intersection of fluids; for making water-in-oil emulsion droplets , requires localized hydroph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B33Y10/00B33Y80/00
CPCB01L3/502707B01L2300/08B33Y10/00B33Y80/00
Inventor 陈皓生冯玉振李疆朱迪
Owner TSINGHUA UNIV
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