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Self-assembled nanostructure and preparation method thereof

A nanostructure and self-assembly technology, applied in pharmaceutical formulations, preparations for in vivo tests, and medical preparations with inactive ingredients, etc., can solve the problems of long half-life and chronic toxicity of iron oxide, and achieve improved efficiency and improved development. effect of effect

Pending Publication Date: 2018-01-05
SPRING FOUND OF NCTU
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, iron oxide has a long half-life and is easy to accumulate in biological tissues, causing chronic toxicity in the long run.

Method used

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  • Self-assembled nanostructure and preparation method thereof
  • Self-assembled nanostructure and preparation method thereof
  • Self-assembled nanostructure and preparation method thereof

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Embodiment

[0063] The self-assembled nanostructure of the present invention is prepared, for example, in the following manner. Get 0.5g of carboxymethylhexanoyl chitosan, 0.2g of gadodiamide and 0.65g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, dissolve in 100mL of phosphate buffer solution (phosphate buffer). The pH of the phosphate buffer solution is 7.4. After stirring at low temperature (4° C.) for 30 minutes, 0.39 g of N-hydroxysuccinimide was added and stirred at low temperature (4° C.) for 24 hours. After the reaction was completed, the solution was dialyzed against pure water for 48 hours, and then dialyzed against ethanol for 24 hours. Then, the solution was dried and crushed to obtain a yellow powder. The self-assembled nanostructure of the present invention can be obtained by dissolving the yellow powder in an aqueous solution.

[0064] In one embodiment, as shown in Table 1 below, self-assembled nanostructures with different developer contents can be ob...

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Abstract

The invention provides a self-assembled nanostructure and a preparation method thereof. The self-assembled nanostructure comprises amphoteric chitosan and a developer compound, wherein developer compound is grafted onto the amphipathic chitosan. The chemical bonding between the amphiphilic chitosan and the developer compound produces additive and multiplicative effect, so the development effect ofthe developer compound can be further enhanced.

Description

technical field [0001] The present invention relates to a self-assembled nanostructure and its preparation method, and in particular to a self-assembled nanostructure with developing function and its preparation method. Background technique [0002] Magnetic resonance imaging (MRI) is an important tool for diagnosing and staging disease because it is non-invasive and non-radiative. In magnetic resonance imaging, contrast agents are often used to improve the resolution of tissue images. [0003] In the prior art, metal-containing compounds such as superparamagnetic iron oxide or its derivatives are often used as developers. However, iron oxide has a long half-life and is easy to accumulate in biological tissues, which may cause chronic toxicity in the long run. Contents of the invention [0004] In view of this, the present invention provides a self-assembled nanostructure and a preparation method thereof. The prepared self-assembled nanostructure has an excellent develop...

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Application Information

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IPC IPC(8): A61K49/08A61K49/12A61K49/18A61K49/00A61K9/51A61K47/36A61K31/12A61K31/7068A61K33/24
Inventor 郭亭佑黄唯婷刘典谟
Owner SPRING FOUND OF NCTU