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A kit for detecting bacterial vaginosis

A vaginosis and kit technology, applied in the biological field, can solve the problems of easy confusion in use, weak color reaction at room temperature, and high false positives in hydrogen peroxide holes, and achieve the effects of intuitive and accurate inspection results, objective indicators, and simple operation.

Inactive Publication Date: 2018-01-05
RAYBIOTECH INC GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Compared with the dry chemical detection kits of three companies in the market, there are the following problems: 1. The false positive of hydrogen peroxide hole is high; 2. The reaction color at room temperature is weak, and a constant temperature heater is required; 3. The detection index Too much, easy to confuse in use

Method used

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  • A kit for detecting bacterial vaginosis
  • A kit for detecting bacterial vaginosis
  • A kit for detecting bacterial vaginosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0092] A test kit for detecting bacterial vaginosis, the test kit is composed of a test kit body, a detection device, a color developing solution and a sample diluent. The detection device includes four kinds of reaction pads, which are pH value reaction pads, hydrogen peroxide reaction pads, leukocyte esterase reaction pads, and sialidase reaction pads. The carriers of the four kinds of reaction pads are all 3MM filter papers. The box body is respectively provided with a pH value reaction well, a hydrogen peroxide reaction well, a leukocyte esterase reaction well and a sialidase reaction well, and each reaction well is filled with a corresponding reaction pad;

[0093] (1) The pH value reaction pad is the reaction pad obtained by drying the carrier after being soaked in the pH value reaction solution, and the specific formula of the pH value reaction solution is as follows:

[0094] Recipe 1:

[0095] Solution A: bromocresol green: 0.1wt%,

[0096] The rest is absolute etha...

example 42 example ，85％； example 59 example ， test example 58

[0239] The test kit for detecting bacterial vaginosis of the present invention adopts 100 effective samples of the top three hospitals to detect, and the gold standard method (microscopic examination) confirms that the positive cases of bacterial vaginosis are 41 cases, and the test kit for detecting bacterial vaginosis of the present invention confirms 42 cases of positive cases of bacterial vaginosis, the coincidence rate reached 85%; 59 cases of negative cases of bacterial vaginosis were confirmed by the gold standard method, and 58 cases of negative cases of bacterial vaginosis were confirmed by the kit for detecting bacterial vaginosis of the present invention. Rate reaches 88%; The test kit of the present invention detects bacterial vaginosis and the result contrast of hospital gold standard method is as follows

[0240]

[0241]

[0242] It can be seen that using the kit for detecting bacterial vaginosis of the present invention is highly consistent with the effect...

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Abstract

The invention relates to a kit for detecting bacterial vaginosis. The kit includes a detection apparatus, a developing liquid and a sample diluting liquid. The detection apparatus includes a pH valuereaction pad, a hydrogen peroxide reaction pad, a leucocyte esterase reaction pad and a neuraminidase reaction pad. The kit has characteristics of capability of reacting at room temperature, simple operation, objective indexes, and the like, can be adopted as an index for evaluating an endovaginal micro-ecological environment in the gynecology department, and can be used for assisting clinical BVdiagnosis.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a kit for detecting bacterial vaginosis. Background technique [0002] Bacterial vaginosis (Bacterial vaginosis, BV) is due to the imbalance of micro-ecological balance in the vagina, the reduction of normal lactobacilli and the reduction of Gardnerella vaginalis (GV), Prevotellaspp, Bacteroides, An abnormal increase in the number of facultative anaerobic bacteria such as Mobiluncus spp and Mycoplasmahominis is a syndrome without vaginal mucosal inflammation. It was previously known with limited knowledge and was named Haemophilus vaginitis, Gardnerella vaginalis vaginitis, NO-specific vaginitis, and Gardnerella vaginitis etc., are all named differently because of different understandings of their pathogens in different periods. In 1955, Gardner and Dukes isolated Haemophilus vaginalis from the vaginal secretions of patients with atopic vaginitis, and thought it was the pathogenic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/44C12Q1/34C12Q1/28C12Q1/04
CPCC12Q1/04C12Q1/28C12Q1/34C12Q1/44
Inventor 胡守旺黄若磐
Owner RAYBIOTECH INC GUANGZHOU