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A kind of multilayer embedded solid lipid calcium particle

A technology of solid lipid and microparticles, applied in the field of preparations, can solve many problems such as high bioavailability, good mechanical properties, and improved stability

Active Publication Date: 2020-11-13
FERGUSON WUHAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are not many applications for its emulsifying properties, and it has not been used in the preparation of solid lipid particles or the embedding of calcium compounds.

Method used

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  • A kind of multilayer embedded solid lipid calcium particle
  • A kind of multilayer embedded solid lipid calcium particle
  • A kind of multilayer embedded solid lipid calcium particle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]

[0029] 1) Glyceryl monostearate is mixed with polyglycerol fatty acid ester, heated and melted, then calcium carbonate is added, stirred, and homogenized;

[0030] 2) Sodium caseinate was dissolved in water to prepare 6Kg of sodium caseinate solution with a mass fraction of 3%, and then added to the 3Kg mixture obtained in step 1), heated to 75°C, and homogeneously emulsified;

[0031] 3) Dissolve gum ghatti with water to make 50Kg of gum ghatti solution with a mass fraction of 3%, then add it to the 9Kg emulsion obtained in step 2), heat to 75°C, and emulsify homogeneously;

[0032] 4) Stir the emulsion obtained in step 3) in an ice-water bath, rapidly cool down, then add double the weight of water to dilute it, and then spray dry it to obtain the product.

Embodiment 2

[0034]

[0035] 1) Polyglycerol fatty acid ester is heated and melted, then calcium carbonate is added, stirred, and homogenized;

[0036] 2) Sodium caseinate was dissolved in water to make 15Kg of sodium caseinate solution with a mass fraction of 2%, and then added to the 3Kg mixture obtained in step 1), heated to 80°C, and homogeneously emulsified;

[0037] 3) Dissolve gum ghatti with water to make 150Kg of gum ghatti solution with a mass fraction of 2%, then add it to the 18Kg emulsion obtained in step 2), heat to 80°C, and emulsify homogeneously;

[0038] 4) Stir the emulsion obtained in step 3) in an ice-water bath, rapidly cool down, then add water to dilute it, and spray dry it to obtain the product.

Embodiment 3

[0040]

[0041] 1) Heating and melting glyceryl monostearate, then adding calcium phosphate, stirring, and homogenizing;

[0042] 2) Sodium caseinate was dissolved in water to prepare 5Kg of sodium caseinate solution with a mass fraction of 1%, and then added to the 1.5Kg mixture obtained in step 1), heated to 60°C, and homogeneously emulsified;

[0043] 3) Dissolve gum ghatti with water to make 50Kg of gum ghatti solution with a mass fraction of 1%, then add it to the 6.5Kg emulsion obtained in step 2), heat to 60°C, and emulsify homogeneously;

[0044] 4) Stir the emulsion obtained in step 3) in an ice-water bath, rapidly cool down, then add water to dilute it, and spray dry it to obtain the product.

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Abstract

The invention discloses multi-layer embedded solid lipid calcium particles. The multi-layer embedded solid lipid calcium particles are made from the following raw materials of 0.5-2 parts by weight ofinsoluble or micro-soluble calcium, 0.5-2 parts by weight of fatty acid esters, 0.05-0.3 part by weight of sodium caseinate and 0.5-3 parts by weight of Indian gum. According to the multi-layer embedded solid lipid calcium particles disclosed by the invention, the physical and chemical characteristics of the fatty acid esters, the sodium caseinate and the Indian gum are fully utilized, and the fatty acid esters, the sodium caseinate and the Indian gum are used for embedding a calcium source according to a specific sequence by a specific method, so that the multi-layer embedded solid lipid calcium particles high in biological availability, favorable in mechanical properties and favorable in processing characteristics are obtained.

Description

technical field [0001] The invention relates to a multilayer embedded solid lipid calcium particle, which belongs to the field of preparations. Background technique [0002] Calcium is an important substance for bone growth and metabolic regulation of human physiological functions, but calcium deficiency is very common. In recent years, the problem of insufficient calcium intake has attracted widespread attention. In order to meet the needs of people for calcium supplementation, various calcium-fortified foods have emerged as the times require. [0003] At present, the calcium fortifiers used in calcium-supplementing foods in industrial production are mostly inorganic calcium and biological calcium, mainly because these two types of calcium fortifiers are low in cost and high in calcium content, but they generally have the disadvantages of poor calcium solubility and low absorption and utilization rate. In addition, in addition to milk calcium, calcium fortifiers are added ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A23L33/10A23P10/20A23P30/00A23L29/00A23L29/25
Inventor 姚晓琳高玉静何亚婷张琨李帅欧阳康乐
Owner FERGUSON WUHAN BIOTECH
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