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Pharmaceutical compound preparation and application of pharmaceutical compound preparation in preparing medicines for treating hypertension with coronary heart disease

A compound preparation and drug technology, applied in the field of medicine, can solve the problems of poor patient compliance, high cost of long-term medication, and a wide variety of medication, and achieve significant curative effects.

Inactive Publication Date: 2018-01-19
GUILIN HAOXIN TECH SERVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine treats coronary heart disease combined with hypertension to treat the two diseases separately. There are many kinds of medicines, increased incidence of side effects, high cost of long-term medication, and poor patient compliance.

Method used

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  • Pharmaceutical compound preparation and application of pharmaceutical compound preparation in preparing medicines for treating hypertension with coronary heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Formula composition:

[0021] 15 parts by weight of lovastatin

[0022] 15 parts by weight of bumetanide

[0023] 20 parts by weight of metolazone

[0024] 10 parts by weight of citric acid

[0025] 10 parts by weight of butylated hydroxyanisole

[0026] 40 parts by weight of lactose

[0027] 25 parts by weight of hydroxypropyl cellulose

[0028] 20 parts by weight of sodium carboxymethyl starch

[0029] 10 parts by weight of micronized silica gel

[0030] Preparation:

[0031] 1) Take prescription amounts of lovastatin, bumetanide, and metolazone, add citric acid, butylated hydroxyanisole, and lactose to mix well, and set aside.

[0032] 2) Add hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone and sodium carboxymethyl starch to 1) and mix thoroughly, pass 80 mesh sieve, ethanol made soft material, pass 14 mesh sieve for granulation.

[0033] 3) Dry, granulate, add micro-powdered silica gel and mix well, then press into tablets, ready to be obtained.

Embodiment 2

[0035] Formula composition:

[0036] Lovastatin 20 parts by weight

[0037] Bumetanide 20 parts by weight

[0038] 35 parts by weight of metolazone

[0039] 20 parts by weight of citric acid

[0040] 20 parts by weight of butylated hydroxyanisole

[0041] 50 parts by weight of lactose

[0042] 30 parts by weight of hydroxypropyl cellulose

[0043] 30 parts by weight of sodium carboxymethyl starch

[0044] 15 parts by weight of micronized silica gel

[0045] Preparation:

[0046] 1) Take prescription amounts of lovastatin, bumetanide, and metolazone, add citric acid, butylated hydroxyanisole, and lactose to mix well, and set aside.

[0047] 2) Add hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone and sodium carboxymethyl starch to 1) and mix thoroughly, pass 80 mesh sieve, ethanol made soft material, pass 14 mesh sieve for granulation.

[0048] 3) Dry, granulate, add micro-powdered silica gel and mix well, then press into tablets, ready to be obtained.

Embodiment 3

[0050] Formula composition:

[0051] 5 parts by weight of lovastatin

[0052] 10 parts by weight of bumetanide

[0053] 10 parts by weight of metolazone

[0054] 5 parts by weight of citric acid

[0055] 5 parts by weight of butylated hydroxyanisole

[0056] 25 parts by weight of lactose

[0057] 15 parts by weight of hydroxypropyl cellulose

[0058] 10 parts by weight of sodium carboxymethyl starch

[0059] 2 parts by weight of micronized silica gel

[0060] Preparation

[0061] 1) Take prescription amounts of lovastatin, bumetanide, and metolazone, add citric acid, butylated hydroxyanisole, and lactose to mix well, and set aside.

[0062] 2) Add hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone and sodium carboxymethyl starch to 1) and mix thoroughly, pass 80 mesh sieve, ethanol made soft material, pass 14 mesh sieve for granulation.

[0063] 3) Dry, granulate, add micro-powdered silica gel and mix well, then press into tablets, ready to be obtained.

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PUM

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Abstract

The invention relates to a pharmaceutical compound preparation and application of pharmaceutical compound preparation in preparing medicines for treating hypertension with coronary heart disease. Thepharmaceutical compound preparation comprises the following components in parts by weight: 15-20 parts of lovastatin, 12-20 parts of bumetanide, 15-30 parts of metolazone, 5-15 parts of acid protective agent, 5-15 parts of an antioxidant, 25-55 parts of a filling agent, 15-30 parts of a bonding agent, 10-35 parts of a disintegrating agent and 2-10 parts of a lubricant. According to the pharmaceutical compound preparation, the lovastatin, the bumetanide and the metolazone are combined for treating the hypertension with the coronary heart disease, so that the curative effect is very obvious, theaction of synergistic interaction and advantage complementation are shown, and the side effects of all the medicines also can be reduced.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a drug compound preparation and its use in preparing a drug for treating hypertension complicated with coronary heart disease. Background technique [0002] With the development of society and the improvement of living conditions, the incidence of coronary heart disease is on the rise. Hypertension is an important risk factor for coronary heart disease. For patients with coronary heart disease and hypertension, comprehensive treatment is the best plan, so the development of curative effects Drugs for comprehensive treatment of this disease with high and low side effects have important practical significance. At present, the treatment of coronary heart disease with hypertension by western medicine is to treat the two diseases separately. There are many shortcomings such as a wide variety of medications, an increased incidence of side effects, high long-term medication costs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/517A61K31/366A61K31/22A61K31/196A61P9/12A61P9/10
Inventor 钟传新王君
Owner GUILIN HAOXIN TECH SERVICE
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