Use Of Ginsenoside M1 For Preventing Or Treating Silicosis

A technology of ginsenoside and silicosis, which is applied in the field of ginsenoside M1 for preventing or treating silicosis, and can solve the problems of reporting the therapeutic efficacy of ginsenoside M1

Active Publication Date: 2018-01-26
理筱龙
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no prior art report on the therapeutic efficacy of ginsenoside M1 in silicosis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use Of Ginsenoside M1 For Preventing Or Treating Silicosis
  • Use Of Ginsenoside M1 For Preventing Or Treating Silicosis
  • Use Of Ginsenoside M1 For Preventing Or Treating Silicosis

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] Ginsenoside M1 is known as one of metabolites of protopanaxadiol-type ginsenosides, which are produced via the gypenoside pathway of human intestinal bacteria. After the human body takes ginseng, ginsenoside M1 can be found in blood or urine. Ginsenoside M1 can be prepared from ginseng plants by existing methods in the art such as fungal fermentation, for example, China Taiwan Invention Patent Application No. 094116005 (I280982) and US Patent No. 7,932,057, the entire contents of which are incorporated herein This case is used as reference data. In some specific embodiments, the ginseng plants used to prepare ginsenoside M1 include Araliaceae (Araliaceae), Panax genus (Panax genus), such as ginseng (P.ginseng) and pseudo-ginseng (P.pseudo-ginseng) (also known as Panax notoginseng). Generally speaking, the preparation method of ginsenoside M1 comprises the steps of: (a) providing powder of ginseng plant material (such as leaf or stem); (b) providing fungi for fermentat...

Embodiment

[0046] 1. Materials and methods

[0047] Ginsenoside M1, namely 20-β-D-glucopyranosyl protopanaxadiol (20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol) (hereinafter named as LCHK168), is based on existing prepared by the method, as disclosed in Chinese Taiwan Patent Application No. 094116005 (I280982) and US Patent No. 7,932,057.

[0048] Mouse macrophage cell line J774A.1 and human monocytogenes and leukocyte cell line THP-1 were purchased from the American Type Culture Collection (Rockville, MD) and cultured in the addition of 10% fetal bovine serum deactivated by high temperature and 2mM L- Glutamine-based RPMI 1640 medium (both purchased from Life Technologies, Carlsbad, CA) was incubated at 37°C, 5% CO 2 in the incubator. To induce differentiation of monocytes into macrophages, THP-1 was cultured in RPMI-1640 for 48 hours with the addition of 100 nM phorbol 12-myristate 13-acetate (Sigma-Aldrich).

[0049] figure 1 Medium, J774A.1 macrophages (1x10 5 cells / 500 μl cultu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention discloses a new use of ginsenoside M1 for treating or preventing silicosis.

Description

[0001] related application [0002] This application claims priority to US Provisional Application No. 62 / 134,236, filed March 17, 2015, the contents of which are hereby incorporated by reference in their entirety. technical field [0003] The invention relates to a new application of ginsenoside M1 for treating or preventing silicosis. Background technique [0004] Silicosis is a lung disease caused by inhalation of silica particles, usually from working in mines and quarries and some other occupations such as construction, foundries, ceramics and glass manufacturing. Silica particles affect lung function. Symptoms include shortness of breath, severe coughing, and weakness. [0005] Ginsenosides, the main active ingredients of ginseng, are known to have various pharmacological activities, such as antitumor, antifatigue, antiallergic, and antioxidant activities. Ginsenosides have the same basic structure, which is composed of a gonane steroid nucleus with 17 carbon atoms ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P11/00
CPCA61K31/7032A61K31/704A61P11/00A61P19/06
Inventor 理筱龙理昱杰花国峰
Owner 理筱龙
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap