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A kind of oxytocin transdermal agent and its preparation method and application
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A technology of oxytocin and transdermal agent is applied in the field of agricultural breeding, which can solve the problems of abnormal fetal position and lack of amniotic fluid lubrication in the birth canal, and achieve the effects of long maintenance time, reduction in the number of piglets death and increase in economic benefits.
Active Publication Date: 2020-07-10
武汉华扬天乐生物科技有限公司
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Problems solved by technology
Because of the uterine spasm caused by a large amount of oxytocin, it may lead to abnormal fetal position, lack of amniotic fluid lubrication in the birth canal after amniotic fluid loss, and finally have to cull sows, resulting in greater economic losses
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Embodiment 1
[0025] Measure 160ml of propylene glycol, weigh 200μg of oxytocin, dissolve in propylene glycol, stir to dissolve; measure 400ml of absolute ethanol, weigh 1g of flunixin meglumine, dissolve in absolute ethanol, stir to dissolve, mix propylene glycol and absolute ethanol The two solutions were stirred for 2 minutes, 40ml of azone, 60ml of oleic acid, and 200ml of dimethyl sulfoxide were added in sequence, and finally the volume was adjusted to 1000ml with absolute ethanol, and stirred for 3 minutes.
Embodiment 2
[0027] Measure 120ml of propylene glycol, weigh 200μg of oxytocin, dissolve in propylene glycol, stir to dissolve; measure 250ml of absolute ethanol, weigh 1g of flunixin meglumine, dissolve in absolute ethanol, stir to dissolve, mix propylene glycol and absolute ethanol The two solutions were stirred for 2 minutes, 20ml of azone, 80ml of oleic acid, and 400ml of dimethyl sulfoxide were added in sequence, and finally the volume was adjusted to 1000ml with absolute ethanol, and stirred for 3 minutes.
Embodiment 3
[0029] Measure 80ml of propylene glycol, weigh 200μg of oxytocin, dissolve in propylene glycol, stir to dissolve; measure 400ml of absolute ethanol, weigh 1g of flunixin meglumine, dissolve in absolute ethanol, stir to dissolve, mix propylene glycol and absolute ethanol Stir the two solutions for 2 minutes, add 30ml of azone, 80ml of oleic acid, and 300ml of dimethyl sulfoxide in sequence, and finally dilute to 1000ml with absolute ethanol, and stir for 3 minutes.
[0030] The oxytocin transdermal agent of the present invention was tested in Xishui Changliu Pig Farm, Huanggang, Hubei, and 40 large white sows with 3 to 5 parities were selected and divided into four groups, one of which was a control group without using drugs, and the other three Group is the test group, is test group 1, test group 2, test group 3 respectively, when sow gives birth to the first piglet, smears the oxytocin transdermal of above-mentioned embodiment 1, embodiment 2, embodiment 3 respectively on the ...
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Abstract
The invention provides an oxytocin transdermal agent. The oxytocin transdermal agent comprises a drug liquid, oxytocin, and flunixin meglumine; each 100ml of the drug liquid contains 100 to 300<mu>g of oxytocin, and 1 to 3g of flunixin meglumine. The drug liquid comprises, by volume fraction, 22 to 44% of a transdermal enhancer, 6 to 10% of oleic acid, 8 to 16% of propylene glycol, and 31 to 54% of absolute ethyl alcohol. The oxytocin transdermal agent enters into sows through transdermal absorption, is capable of shortening sow labor stage, and reducing increasing of piglet mortality caused by prolong labour; flunixin meglumine is capable of relieving sows parturition pain and inflammatory response, promoting sow postpartum recovery, increasing food intake and milk secretion, and improving economical benefits.
Description
technical field [0001] The invention belongs to the technical field of agricultural breeding, and in particular relates to an oxytocin transdermal agent, a preparation method and application thereof. Background technique [0002] Oxytocin is a peptide hormone secreted by the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus and released into the blood through the posterior pituitary gland. It is a monoamine composed of 9 amino acids. can hormones. Oxytocin directly excites uterine smooth muscle, and small doses of oxytocin strengthen the rhythmic contraction of the uterus (especially the uterus at the end of pregnancy), increasing the contraction amplitude and slightly increasing the tension. The nature of the contraction is similar to that of normal childbirth. Rhythmic contraction occurs, and the smooth muscle of the cervix relaxes to promote fetal delivery. As the dose increases, the uterine muscle tension will continue to increase, and fina...
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Application Information
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