The invention discloses an intermittent ultrasonic reaction device. The intermittent ultrasonic reaction device comprises a protective cover, ultrasonic acoustical systems, a screw, a first throttle valve, an ultrasonic transmitting groove, first bolts, a four-way flow dividing pipe, pressure nozzles, first clamp nuts, a gas-liquid exchange reaction chamber, gas guide holes, second bolts, lead screws, third bolts, a cover, second clamp nuts, a supporting ring, double nuts, a second throttle valve, a third throttle valve, a fourth throttle valve, a fifth throttle valve, a booster pump, stirring paddles and a circulation liquid storage groove. According to the intermittent ultrasonic reaction device, under the action of ultrasonic cavatition, reaction liquid is refined more evenly and finely; in the crystallization process, crystal grains can be effectively refined, and the crystal grains can be prevented from growing up; the catalyst surface can be updated in time, and the catalyst activity can be kept; the device can be widely used in the large-scale process such as sewage treatment and chemical industry production.