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Systems and methods for precise diagnosis and treatment enhanced by cancer grade mapping

A tumor grading, ultrasound system technology, used in the field of oncology diagnosis and treatment

Active Publication Date: 2021-06-15
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the diffuse nature of typical prostate tumors makes effective targeting of high-grade tumor regions via focused therapy a challenging task

Method used

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  • Systems and methods for precise diagnosis and treatment enhanced by cancer grade mapping
  • Systems and methods for precise diagnosis and treatment enhanced by cancer grade mapping
  • Systems and methods for precise diagnosis and treatment enhanced by cancer grade mapping

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Embodiment Construction

[0018] Prostate tumors are usually graded by histopathological examination using samples collected by transrectal ultrasound-guided biopsy. However, the ultrasound usually (at best) indicates the location of suspicious areas of the prostate, but cannot determine the tumor grade of these areas (or even whether they are cancerous). Therefore, there is no guarantee that the biopsy will sample the highest grade tumor present in the prostate. Additionally, the transrectal nature of the procedure often limits the number of samples that can be practically collected. Repeated transrectal biopsy procedures are also undesirable.

[0019] The generation of tumor grade maps from transrectal ultrasound images using existing raw "RF" time series data acquired by transrectal ultrasound imaging is disclosed herein. (The term "RF" generally refers to "radio frequency". In the context of ultrasound, imaging ultrasound pulses are at sonic frequencies, which are usually in the megahertz range c...

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Abstract

An ultrasound system for performing tumor grade mapping comprising: an ultrasound imaging device (10) that acquires ultrasound imaging data; an electronic data processing device (30) programmed to generate an ultrasound image (34) from the ultrasound imaging data ), and programmed to generate a tumor grade map (42) by (i) extracting from said ultrasound imaging data a set of local features representing the map pixels of the tumor grade map, and (ii) using tumor grade classification a device (46) that classifies the set of local features to generate a tumor grade for the map pixels of the tumor grade map; a display component (20) that displays the tumor grade map, e.g., as a color-coded A tumor grade map overlay is superimposed on the ultrasound image. The tumor grade classifier is learned from a training data set (64) comprising a set of local features extracted from ultrasound imaging data at a biopsy site and labeled with histopathological tumor grade.

Description

technical field [0001] The following generally relates to the field of oncology diagnosis and treatment, the field of biopsy and tissue sample collection, the field of image-guided medical procedures, and related fields. The following is described with specific reference to prostate tumor diagnosis and treatment, but will apply to the diagnosis and treatment of other types of cancer, such as liver cancer, breast cancer, and the like. Background technique [0002] In 2014, prostate cancer was the most common type of cancer among men and the second leading cause of cancer-related death in the United States. Each year, more than 230,000 American men are diagnosed with prostate cancer and nearly 30,000 die from the disease. Prostate cancer is suspected if there is an increased level of prostate-specific antigen (PSA) in the blood, palpable nodules, a family history of prostate cancer, or if a hypoechoic area is seen on an ultrasound image of the prostate. However, blood PSA te...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B8/12A61B8/08A61B8/00A61B10/02G06K9/62G06T7/00G06T7/41A61N5/10G06V10/764
CPCG06T7/41A61B8/08A61B8/12A61B8/463A61B8/485A61B8/5223A61B10/0241G06T7/0012A61N5/1001G06T2207/30081G06T2207/30096G06T2207/20081G06T2207/10132G06V2201/03G06F18/24G16H50/30G06V10/764
Inventor L·博罗茨基A·M·塔赫玛塞比马拉古奥施S·巴拉特
Owner KONINKLJIJKE PHILIPS NV