Hydroxybenzene derivative detection reagent, its preparation method and tumor screening reagent
A technology for detecting reagents and derivatives, which is applied in the field of hydroxybenzene derivatives detection reagents and tumor screening reagents. It can solve the problems of low early tumor detection rate, high cost, and traumatic diagnosis methods, and achieves a simple preparation process. Convenience, high detection rate, and high detection effect
Active Publication Date: 2019-05-24
SHENZHEN RADAK BIO CORP
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[0008] In view of the above technical problems, the embodiment of the present invention provides a hydroxybenzene derivative detection reagent, its preparation method and a tumor screening reagent, so as to solve the problem that the existing diagnostic methods are traumatic, costly, and the detection rate of early tumors is not high. The problem
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[0041] Such as figure 1 Shown, the preparation method of described hydroxybenzene derivative detection reagent comprises the steps:
[0042] 101. Preparation of solution A: Weigh a certain weight of mercury and dissolve it in concentrated nitric acid, and add ultrapure water twice the volume of concentrated nitric acid to dilute to obtain a mercury nitrate solution.
[0043] 102. Preparation of solution B: Weigh a certain weight of mercurous nitrate and dissolve it in 4.2 mol / L nitric acid to obtain a 230-250 g / L mercurous nitrate solution.
[0044] 103. Prepare solution C: weigh a certain weight of p-dimethylaminobenzaldehyde and dissolve it in 10.7 mol / L sulfuric acid to obtain a 3-5 g / L p-dimethylaminobenzaldehyde solution.
[0045] 104. Preparation of solution D: Weigh a certain weight of sodium nitrite and dissolve it in ultrapure water to obtain a 0.001-0.004 g / L sodium nitrite solution.
[0046] 105. Preparation of solution E: Weigh a certain weight of nickel nitrate ...
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The embodiment of the invention discloses a hydroxybenzene derivative detection reagent and a preparation method thereof, and a tumor detection reagent. According to the volume ratio, the hydroxybenzene derivative detection reagent comprises the components: 1 of a solution A; 0.3-0.5 of a solution B; 0.16-0.18 of a solution C; 0.2-0.6 of a solution D; and 0.07-0.08 of a solution E, wherein the solution A is a dilute solution obtained after mercury is dissolved in concentrated nitric acid; the solution B is a 230-250 g / L mercurous nitrate nitric acid solution; the solution C is a 3-5 g / L paradimethylaminobenzaldehyde sulfuric acid solution; the solution D is a 0.001-0.004 g / L sodium nitrite solution; and the solution E is a 300-500 g / L nickel nitrate solution. The hydroxybenzene derivativedetection reagent is simple and convenient in preparation process, and is suitable for conventional production and manufacturing. In addition, the hydroxybenzene derivative detection reagent not onlyhas a high detection rate for most benign tumors, but also has a high detection effect on gastrointestinal tumors and some high-attack non-gastrointestinal tumors, such as bladder cancer, cervical cancer and breast cancer.
Description
technical field [0001] The invention relates to the technical field of biological detection reagents, in particular to a hydroxybenzene derivative detection reagent, a preparation method thereof and a tumor screening reagent. Background technique [0002] Tumor is one of the main causes of human cancer. Tumors are divided into benign tumors and malignant tumors. Among them, benign tumors are likely to cause symptoms such as fatigue and loss of appetite in patients, causing people to misjudge their own physical conditions, thus ignoring the attention and treatment of tumors, while during the period of malignant tumors, patients begin to show symptoms related to cancer, Clinical testing and treatment at this time will definitely bring greater economic losses, physical torture and mental stress to cancer patients. [0003] The commonly used diagnostic methods in clinical practice include ultrasonography, CT, radionuclide imaging, endoscopy, and fine-needle aspiration cytology...
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IPC IPC(8): G01N33/574
CPCG01N33/57484
Inventor 邓兴朝穆洪涛黄连生刘凤银陈秀珊李嘉慧
Owner SHENZHEN RADAK BIO CORP