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Application of RDH10 (retinol dehydrogenase 10) gene to preparation of TWEAK-NF-kappaB signal pathway blocking agent

An RDH10 and signaling pathway technology, applied in the research field of glioma pathogenesis, can solve the problems such as no RDH10 gene application report, unknown RDH10 gene biological function and clinical significance, etc.

Active Publication Date: 2018-02-27
BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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Problems solved by technology

The biological function and clinical significance of RDH10 gene in glioma are still unknown, so far there is no report on the application of RDH10 gene in glioma disease in domestic and foreign literatures

Method used

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  • Application of RDH10 (retinol dehydrogenase 10) gene to preparation of TWEAK-NF-kappaB signal pathway blocking agent
  • Application of RDH10 (retinol dehydrogenase 10) gene to preparation of TWEAK-NF-kappaB signal pathway blocking agent
  • Application of RDH10 (retinol dehydrogenase 10) gene to preparation of TWEAK-NF-kappaB signal pathway blocking agent

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Embodiment Construction

[0024] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and not to limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0025] Materials and methods

[0026] Glioma specimen collection and RDH10 immunohistochemical analysis

[0027] 150 samples of glioma were used for research, and this study was approved by the Ethics Committee of Beijing Tiantan Hospital Affiliated to Capital Medical University; among the 150 samples, the number of samples of different glioma grades was similar. We stained, formalin-fixed, paraffin-embedded tissues using the IHC met...

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Abstract

The invention discloses application of a RDH10 (retinol dehydrogenase 10) gene to preparation of a TWEAK-NF-kappaB signal pathway blocking agent. A positive correlation exists between RDH10 gene expression and the glioma grade, and RDH10 gene knockout regulates proliferation of neuroglioma cells in vitro, causes S and G2 / M cell cycle arrest, inhibits the RDH10 gene to cause growth retardation of the glioma cells, and causes decrease in cell invasion ability of the glioma cells. RDH10 gene knockout changes related expression of the TNFRSF12A (TWEAKR), TRAF1, TRAF3, BMPR2, TNFAIP3, NFKBIA, NFKBIE and IKBKB, and such a result shows that the RDH10 may affect the proliferation, the apoptosis and the cell cycle of the glioma cells by regulating a TWEAK-NF-kappaB signal pathway. Researches find that the RDH10 plays an important role in occurrence and progression processes of the gliomas. Studies on the functions of the RHD10 gene provide a powerful method for targeted treatment to human neurogliomas.

Description

technical field [0001] The invention relates to the research field of the pathogenesis of brain glioma, in particular to the application of an RDH10 gene for preparing a TWEAK-NF-κB signaling pathway blocker. Background technique [0002] Glioma is the deadliest type of human brain malignancy, and there is still no effective treatment. Epidemiological data show that glioma accounts for 32%-45% of primary brain tumors and nearly 70%-80% of malignant brain tumors. In addition, the survival time of nearly 95% of glioma patients is less than 5 years, and the 5-year survival period of glioblastoma is even less than 5%. Although some achievements have been made in surgical treatment, radiation therapy and chemotherapy for glioma, the treatment of glioma is still a challenge in clinical oncology. In order to obtain the desired therapeutic effect, researchers conducted in-depth studies on the underlying molecular mechanisms and genetics of human glioma. Although the genomic map o...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/158
Inventor 张俊廷关峰王亮康庄
Owner BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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