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Application of eriodictyol in preparation of medicine for treating AD (alzheimer's disease)

A technology for Alzheimer's disease and eriodictin, which is applied in the application field of North American eriodictin in the preparation of drugs for treating Alzheimer's disease

Inactive Publication Date: 2018-03-23
黑龙江葆纳生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The remarkable anti-inflammation, anti-oxidation, free radical scavenging and anti-apoptotic effects of eriodictym have been confirmed, but there are few related studies on the neuroprotection of eriodictym

Method used

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  • Application of eriodictyol in preparation of medicine for treating AD (alzheimer's disease)
  • Application of eriodictyol in preparation of medicine for treating AD (alzheimer's disease)
  • Application of eriodictyol in preparation of medicine for treating AD (alzheimer's disease)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0035] 1. Experimental materials:

[0036] Cell line: rat adrenal pheochromocytoma cell line PC-12, purchased from the Cell Bank of the Chinese Academy of Sciences.

[0037] Drugs and reagents: Aβ 25-35 , purchased from Wuhan Boster Biological Engineering Co., Ltd.; β-estradiol (purity 98%, production batch number L750N46), purchased from Beijing Bailingwei Technology Co., Ltd.; ), purchased from Chengdu Master Biotechnology Co., Ltd.; fetal bovine serum (FBS), high glucose medium (DMEM), double antibody, trypsin, purchased from Hyclone Company; AMV reverse transcription kit, PCR amplification kit , RT-PCR primers, purchased from Shanghai Bioengineering Co., Ltd.; RT-PCR kit, purchased from Fermentas company; Tetramethylthiazolium blue (MTT), dimethyl sulfoxide (DMSO), purchased from Sigma company; Tween- 20. TEMED, purchased from Sigma Company; ultra-sensitive ECL chemiluminescence kit, purchased from Beyond Biotechnology Research Institute; Western and IP cell lysate, TRIZ...

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Abstract

The invention relates to an application of eriodictyol in preparation of a medicine for treating the AD (alzheimer's disease). A beta 25-35 damaged PC-12 cell is taken as an in-vitro model of the AD,estradiol is taken as positive control, the anti-AD effect of eriodictyol and the action mechanism producing the effect are researched from the view of anti-apoptosis, a solid experimental foundationand theoretical foundation are laid for treatment of the AD and other nervous centralis degenerative diseases by use of phytoestrogen from the molecular level, and the eriodictyol has important actualapplication value.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of eriodictine in the preparation of drugs for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD for short), also known as primary senile dementia, is a degenerative disease of the nervous system. Epidemiological studies have shown that AD is an age-related disease whose incidence increases with age. It is about 5% of people over 65 years old, and about 20% of people over 85 years old. [0003] After research, estrogen can prevent and treat AD in a multi-channel and multi-link manner, but long-term use of estrogen is prone to side effects such as uterine bleeding, breast cancer, and endometrial cancer. Therefore, people hope to find drugs that can replace estrogen. Phytoestrogens are a class of ingredients that can bind to and activate estrogen receptors in mammals and humans, thereby exerting estrogen-like or anti-estrogen activity. Ph...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P25/28
CPCA61K31/352
Inventor 张宁耿放刘国良刘斌王发善宋垚辰
Owner 黑龙江葆纳生物科技有限责任公司
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