Particle size screening and homogenizing adjustable magnetic field generator for biological nanometer magnetic beads

Abstract

The invention discloses a particle size screening and homogenizing adjustable magnetic field generator for biological nanometer magnetic beads. The particle size screening and homogenizing adjustablemagnetic field generator comprises an iron core with a rectangular frame-shaped framework. A notch is arranged in the middle of a long edge of the iron core and is used for arranging to-be-processed nanometer magnetic bead samples; multiple layers of magnetic induction coils are wound at other three edges of the iron core, each layer of magnetic induction coils is partitioned by electric fish paper, and the magnetic induction coils are powered by a direct-current power supply; laser cutting machining is carried out on electric pure iron plates with high magnetic permeability to obtain the ironcore, and a single enameled wire is tightly wound on the outside of the iron core along the same direction according to right hand rules to form each magnetic induction coil. The particle size screening and homogenizing adjustable magnetic field generator has the advantages that the magnetic beads with the different particle sizes can be screened by the particle size screening and homogenizing adjustable magnetic field generator, large bulky aggregate and small magnetic beads with weak magnetism can be removed in preparation procedures, and accordingly particle size screening and particle andmagnetic responsiveness homogenization effects can be realized for the magnetic beads.

Description

Technical field [0001] The invention relates to the technical field of biological nano magnetic beads, in particular to an adjustable magnetic field generator used for particle size screening and homogenization of biological nano magnetic beads. Background technique [0002] Bio-nanomagnetic beads are a special functional material used in the field of nucleic acid extraction. Using this material to extract nucleic acid molecules with high purity and structural integrity from samples is the key to determining downstream PCR amplification and nucleic acid detection experiments. Generally, bio-nanomagnetic beads used in nucleic acid extraction should have the following characteristics in terms of manipulation: optional particle size, uniform particle size, and rapid magnetic response. The current preparation of bio-nanomagnetic beads is mainly completed by the following steps: firstly prepare nanoparticles with good magnetic properties as the magnetic core of the nanomagnetic beads...

AI Technical Summary

Problems solved by technology

Although this method is simple to operate, low in cost and easy to produce in large quantities, the problem that the particle size of the magnetic beads is different and the distribution is relatively wide is difficult to solve by improving the preparation method

In recent years, the preparation of nanoparticles by hydrothermal method is also a research hotspot. Nanoparticles with good shape and uniform particle size can be prepared by this method, but the repeatability is poor, and it is difficult to prepare nanoparticles of a specific size by controlling the experimental conditions.

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