Compositions and methods for the treatment of mucositis

A composition, compound technology, applied in the direction of drug combinations, anti-inflammatory agents, pharmaceutical formulations, etc., can solve problems such as limiting the effectiveness of cancer treatment, delaying treatment, and limiting the ability of patients to tolerate chemotherapy or radiation therapy.

Inactive Publication Date: 2018-04-03
CELLIXBIO PTE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mucositis can also limit a patient's ability to tolerate chemotherapy or radiation therapy
Mucositis can be so severe that it delays treatment and thus limits the effectiveness of cancer treatments

Method used

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  • Compositions and methods for the treatment of mucositis
  • Compositions and methods for the treatment of mucositis
  • Compositions and methods for the treatment of mucositis

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Experimental program
Comparison scheme
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Embodiment Construction

[0079] definition

[0080] As used herein, the following terms and phrases shall have the meanings set forth below. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.

[0081] Compounds that have the same molecular formula but differ in properties or in the sequence in which their atoms are bonded or in the arrangement of their atoms in space are termed "isomers". Isomers that differ in the arrangement of their atoms in space are termed "stereoisomers". Diastereomers are stereoisomers that are not enantiomers, but have the opposite configuration at one or more chiral centers. Stereoisomers with one or more asymmetric centers that are non-superimposable mirror images of each other are termed "enantiomers". When a compound has an asymmetric center, for example, if one carbon atom is bound to 4 different groups, then one enantiomer is possible. Enantiomers can be characterized ...

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Abstract

The invention relates to the compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII and formula VIII, or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII and formula VIII, and methods for the treatment of mucositis may be formulated for oral, mouth wash, buccal, rectal, topical, transdermal, transmucosal, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of oral and gastrointestinal mucositis, mucosal inflammatory and oral infectious diseases.

Description

[0001] priority [0002] This application claims priority from Indian Provisional Patent Application No. 622 / CHE / 2015 filed February 9, 2015, the entire disclosure of which is hereby incorporated by reference for all purposes. technical field [0003] The present disclosure generally relates to compounds and compositions useful in the treatment of mucositis. More particularly, the present invention relates to treating a subject with a pharmaceutically acceptable dose of a compound, crystal, solvate, enantiomer, stereoisomer, ester, hydrate, prodrug, or mixture thereof. . Background technique [0004] Oral mucositis, also known as stomatitis, is a common, debilitating complication of cancer chemotherapy and radiation therapy, occurring in approximately 40% of patients. It results from systemic effects of cytotoxic chemotherapeutic agents and local effects of radiation therapy on the oral mucosa. Oral mucositis is inflammation of the oral mucosa ranging from redness to sev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D313/12C07D231/56A61K31/416A61K31/335A61P29/00A61P1/02A61P1/04A61P11/04A61P17/00A61P25/22A61P25/24A61P17/04A61P25/20A61P25/00
CPCC07D231/56C07D313/12A61P1/02A61P1/04A61P11/04A61P17/00A61P17/04A61P25/00A61P25/04A61P25/20A61P25/22A61P25/24A61P29/00A61P37/00
Inventor 马赫什·堪杜拉
Owner CELLIXBIO PTE LTD
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