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Neuron electronic pulse generating system and method

An electronic pulse and generation system technology, applied in electrotherapy, artificial respiration, treatment and other directions, can solve the problems of current pulse stimulation, unable to provide set waveforms for neurons, and achieve the effect of satisfying stimulation needs

Inactive Publication Date: 2018-04-06
AFFILIATED HOSPITAL CHINA ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a neuron electronic pulse generation system and method to solve the problem that the existing electronic equipment cannot provide neurons with current pulse stimulation with a set waveform and set noise

Method used

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  • Neuron electronic pulse generating system and method

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Experimental program
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Embodiment 1

[0042] To achieve the above objectives, the specific block diagram of the system of the present invention is as follows: figure 1 Shown: a neuron electronic pulse generation system, which includes:

[0043] The central processing module sets the waveform parameters and noise parameters in advance, and generates a noise digital signal according to the noise parameters. In the embodiment of the present invention, the central processing module adopts the embedded microcontroller of the ARM Cortex-M3 architecture, the main frequency is 100MHz; the memory size is 2M; the NANDFLASH memory size is 128M; it is equipped with a real-time operating system to ensure the real-time performance and stability of the system, and is responsible for the entire system Input and output control, waveform processing. The central processing module is respectively connected to the waveform generation module and the noise digital-to-analog conversion module, and is used to send the waveform parameters to ...

Embodiment 2

[0052] On the basis of embodiment 1, the embodiment of the present invention can specifically adopt such as figure 2 The connection form shown, namely

[0053] In the embodiment of the present invention, the waveform generation module is a programmable waveform generator AD9833 as the waveform output source. The principle diagram of AD9833 is as follows image 3 As shown, according to the input parameters, set the waveform type output of the waveform generator to be a sine wave or a square wave or other waveforms. The analog stimulation signal is filtered and sent to the first amplifier; the first amplifier is used to adjust the amplitude of the analog stimulation signal. The first amplifier in the embodiment of the present invention can be a programmable gain amplifier AD8320. The schematic diagram of AD8320 is as follows Figure 4 Shown.

[0054] In the embodiment of the present invention, the noise digital-to-analog conversion module takes the high-precision DAC conversion chip...

Embodiment 3

[0061] The present invention also provides a neuron electronic pulse generation method, which includes the following steps:

[0062] Set waveform parameters and noise parameters;

[0063] Generate pulse signals according to waveform parameters;

[0064] Generate noise signals according to noise parameters;

[0065] Superimpose and mix the pulse signal and noise signal to obtain an analog stimulation signal;

[0066] The analog stimulation signal is output through the stimulation electrode;

[0067] Analyze and monitor analog stimulation signals.

[0068] The method of the present invention has the following advantages:

[0069] The invention can output current analog stimulation signals meeting requirements according to the set waveform parameters, and supports noise superposition to meet the user's demand for stimulation of rat brain nerves.

[0070] The invention can observe the current current output waveform in real time through the display screen.

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Abstract

The invention discloses a neuron electronic pulse generating system and method, and aims at solving the problem that present electronic equipment cannot provide current pulse stimulation of set waveform and noise for neurons. The system comprises a central processing module, a waveform generation module, a noise digital to analog conversion module, an integrating module, an output, feedback and analog to digital conversion module and a display module; the central processing module sets waveform and noise parameters in advance, and generates a digital noise signal according to the noise parameter; the waveform generation module generates an analog stimulation signal according to the waveform parameter; the noise digital to analog conversion module converts the digital noise signal into an analog noise signal; the integrating module integrates the analog stimulation signal with the analog noise signal; an analog current signal obtained by integrating is output by a stimulation electrode;the output, feedback and analog to digital conversion module carries out analog-to-digital conversion on the integrated analog current signal, and back feeds and inputs the signal to the central processing module; the central processing module analyzes and monitors the feedback signal in real time and adjusts output of the stimulation signal; and the display module displays output waveform and waveform and noise parameters in real time.

Description

Technical field [0001] The invention relates to the technical field of electronic pulse generation, in particular to a neuron electronic pulse generation system and method. Background technique [0002] In the process of studying the stochastic resonance characteristics and mechanism of compact dopamine neurons in the substantia nigra of Parkinson's rats, the rat neurons need to be stimulated with current pulses in order to give the deep nuclei of the rat brain dense nuclei of the substantia nigra The group is given low-voltage 3.5HZ to 10Hz frequency stimulation, and the nerve nucleus is electrically stimulated through the nerve electrical stimulation needle. Studies have found that the noise carried in the signal may be an important cause of Parkinson's disease. Therefore, it should be necessary to add noise when applying current pulse stimulation to rat neurons. [0003] In order to achieve the above objective, an electronic device that can provide customized current pulse sti...

Claims

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Application Information

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IPC IPC(8): A61N1/36
CPCA61N1/3605A61N1/36125
Inventor 薛伟宁
Owner AFFILIATED HOSPITAL CHINA ACADEMY OF MILITARY MEDICAL SCI