Cetirizine injection

Abstract

The invention discloses a novel cetirizine injection dosage and a method for preparing the cetirizine injection. A cetirizine hydrochloride injection with the advantages of stable content, low impurity content, and long validity period is prepared from cetirizine, a pH adjuster and an osmotic pressure regulator. The cetirizine injection has the advantages of small cetirizine dosage, good safety, realization of timely inhibition of the conditions of anaphylaxis patients, simplicity in use, easiness in obtaining of raw materials, and convenience in industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a cetirizine injection. Background technique [0002] In recent years, due to climate and environmental changes, various harmful gases, dust and other pollution sources have emerged in large numbers, making them allergens that cause people to have various allergic reactions. Seasonal changes, field work, pollen allergies, inhalation of harmful gases and dust particles, etc., have caused more and more people to suffer from various types of allergic diseases, such as allergic rhinitis, urticaria, skin redness, itching, rashes, etc. Red spots and asthma caused by allergens are very common. Fatal anaphylaxis is relatively rare, milder forms of anaphylaxis occur much more frequently than anaphylaxis, and acute anaphylaxis is increasing in frequency, possibly due to the increased number of potential allergens to which people are exposed, such as An ever-growing va...

AI Technical Summary

Problems solved by technology

The only antihistamine injection currently available on the market is diphenhydramine injection. The traditional view is that non-sedating antihistamines cannot be administered by the traditional injection route due to their insolubility, but it has been found in the second generation and the second generation. Among the three generations of antihistamines, only cetirizine-based compounds are readily soluble in water, i.e., only compounds derived from cetirizine or its isomers are soluble in water and can be successfully formulated as parenteral injection products , especially cetirizine for intravenous injection has basically no hemolytic effect of its parent hydroxyzine

[0010] However, the current cetirizine hydrochloride has the disadvantage of unstable properties. Since cetirizine hydrochloride is an acidic drug, it is very easy to chemically react with other substances in the formula, thereby affecting the quality of the product and possibly affecting the quality of the product. product safety

In addition, the content prepared by the prior art is unstable, has high impurity content, affects the dosage, has a short validity period, is not conducive to the transportation and storage of the product, and has potential safety problems

Images