Device, system and method for managing treatment of an inflammatory autoimmune disease of a person

Abstract

The present invention relates to a device, system and method for managing treatment of an inflammatory autoimmune disease of a person. The proposed device comprises an input unit (20) for receiving measurement data acquired over time including white blood cell count data related to the person's white blood cell count, tumor necrotic factor-alpha data related to the person's tumor necrotic factor-alpha, C-reactive protein data related to the person's C-reactive protein, cortisol level data related to the person's cortisol level and melatonin data related to the person's melatonin concentration.The device further comprises a treatment manager (21) for managing treatment of the inflammatory autoimmune disease of the person by combining the obtained measurement data by an algorithm to obtaina disease activity level, to monitor the disease activity level over time and to determine treatment interventions based on the monitored disease activity level.

Description

Technical field [0001] The present invention relates to devices, systems and methods for managing the treatment of inflammatory autoimmune diseases (e.g. rheumatoid arthritis) in humans. Background technique [0002] The biological processes and functions at all levels are organized into discrete time biological rhythms in time. The circadian (24-hour) rhythm (which is of direct importance to clinical medicine) is arranged by the collection of clock genes of the main brain clock located in the suprachiasmatic nucleus of the hypothalamus plus many auxiliary peripheral cell clocks of all tissues and organs. [0003] As known from Rheumatoid Arthritis Circadian Rhythms in Disease Activity, Signs and Symptoms, and Rationale for Chronotherapy with Corticosteroids and Other Medications (Bulletin of the NYU Hospital for Joint Diseases 2012; 70 (Suppl 1): 3-10) by Haus, Erhard et al. The organization and communication of human biological processes and functions require a complex network. ...

AI Technical Summary

Problems solved by technology

However, this may be disturbed in RA patients with high disease activity - reduced and elevated cortical amplitudes of often bimodal rhythms during the morning as well as afternoon and evening daily "quiet periods" of the adrenal alcohol concentration

Cortisol concentrations tend to be elevated in RA patients with high or advanced disease activity, but with insufficient effect to counteract pathological remodeling of affected tissues

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