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Hollow polymer plastic microspheres with micropores on the surface, preparation method and application thereof

A technology of polymers and micropores, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the inconvenience of operation methods, increase the difficulty and uniformity of the preparation methods, and insufficiency Suitable for industrial production and other issues

Active Publication Date: 2020-11-20
GUANGZHOU BLUE MOON IND
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] In summary, the suspension polymerization method, the template method, and the self-assembly method need to go through high temperature, calcination, organic solvent swelling or etching in the preparation process, and there are many inconveniences in the operation method, which is not suitable for industrial production.
The preparation process of surface non-permeable hollow or porous microspheres is prepared after plugging the pores on the surface of the microspheres. Because the pores before plugging are relatively large, reaching micron level, their permeability is very obvious without plugging. However, the plugging step increases the operational difficulty and uniformity of the preparation method

Method used

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  • Hollow polymer plastic microspheres with micropores on the surface, preparation method and application thereof

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preparation example Construction

[0059] In a preferred embodiment of the invention, the preparation method comprises the following steps: firstly, adding an organic solvent into an aqueous solution in which a colloidal protective agent is dissolved, stirring at room temperature to disperse the organic solvent, and gradually increasing the temperature to prepare an oil-in-water droplet suspension; Comprises preparing a mixed solution of polymerization monomer, initiator and cross-linking agent; Dropwise adding the mixed solution into the suspension. By controlling the amount of organic solvent, the polymerization reaction is gradually carried out on the surface of the micro-droplets, thus forming a cross-linked polymer shell on the surface of the micro-droplets. At the initial stage of polymer shell formation, the organic solvent wrapped in the polymer shell slowly volatilizes by adjusting the system temperature, and hollow polymer plastic microspheres with micropores on the surface are formed. After filtering, wa...

Embodiment 1

[0080] A preparation method of cross-linked polymethyl methacrylate-n-butyl acrylate-2-ethylhexyl acrylate hollow polymer plastic microspheres with micropores on the surface, the specific operation steps are as follows:

[0081] (1) Put a reactor equipped with a stirrer and reflux condenser in a water bath, successively add 300.0g of polyvinyl alcohol 1788 (molecular weight of 1700, alcoholysis degree of 88%) water solution and 57.0g of methylcyclohexane into the reactor, adjust the stirring speed to 600rpm / min, stir at room temperature for 10 minutes, start to heat up and stabilize the system temperature at 75℃ to form a stable water-in-water.

[0082] (2) Put 12.0g n-butyl acrylate, 24.0g methyl methacrylate, 5.6g 2-ethylhexyl acrylate and 7.7g methylcyclopentadiene in a beaker, add 1.2g azodiisoheptylnitrile, and stir until diisoheptylnitrile is completely dissolved to form a uniform mixed solution.

[0083] (3) Drop the mixed solution of step (2) into the suspension of step (1...

Embodiment 2

[0091] A preparation method of cross-linked polymethyl methacrylate-n-butyl acrylate-2-ethylhexyl acrylate hollow polymer plastic microspheres with micropores on the surface, the specific operation steps are as follows:

[0092] (1) Put a reactor equipped with a stirrer and reflux condenser in a water bath, successively add 300.0g of aqueous solution of polyvinyl alcohol 1788 (molecular weight 1700, alcoholysis degree 88%) of 5% and 29.4g of cyclohexane into the reactor, adjust the stirring speed to 500rpm / min, stir at room temperature for 10 minutes, start to heat up and stabilize the system temperature at 60℃ to form a stable water-in-water.

[0093] (2) Put 8.0g of n-butyl acrylate, 24.0g of methyl methacrylate, 5.6g of 2-ethylhexyl acrylate and 5.7g of methylcyclopentadiene in a beaker, add 0.7g of benzoyl peroxide, and stir until benzoyl peroxide is completely dissolved to form a uniform mixed solution.

[0094] (3) Dropping the mixed solution of step (2) into the suspension ...

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Abstract

The invention discloses a hollow polymer plastic microsphere with micro-channels on the surface and a preparation method thereof. The pore size is less than or equal to 0.05 microns. The microsphere has elastic non-recoverability. After the cavity of the hollow polymer plastic microsphere is filled with some substances, the substance in the cavity can be released slowly through the micropores of the microsphere without external force; When the external force is applied, the microspheres are deformed, and the substances in the cavity are released at an accelerated rate; when the external force is removed, the deformed microspheres cannot return to their original shape. The microsphere is a high molecular polymer material with low density, good thermal insulation, sound insulation, light scattering and other properties, and can be widely used in medical treatment, cosmetics, cleaning / care products (such as cleaning agents, care agents, etc.), sewage processing, catalyst loading, etc.

Description

Technical field [0001] The invention relates to a hollow polymer plastic microsphere with micropores on its surface, its preparation method and application, and belongs to the field of polymer functional materials. technical background [0002] Hollow polymer microsphere is a kind of microsphere with polymer shell and cavity structure. It has low density, thermal insulation, sound insulation, good light scattering and other properties, and is widely used in catalyst loading, drug slow release, cosmetic coating, sewage treatment and other fields. [0003] At present, the main methods for preparing hollow polymer microspheres include suspension polymerization, self-assembly and solvent evaporation, and acid-base swelling, emulsion polymerization and template method. For the suspension polymerization method, firstly, W / O droplets were prepared by Pickering emulsification method, and then these droplets were dispersed in water phase to form W / O / W suspension system. The initiator in o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/14C08F220/18C08F232/06C08J3/16C08J3/24A61K9/16A61K47/32A61K8/81A61Q19/10
CPCA61Q19/10A61K8/8152A61K9/1635C08F220/14C08J3/16C08J3/24A61K2800/56A61K2800/412C08J2333/12C08F220/1804C08F220/1808C08F220/18C08F232/06C08F220/1802
Inventor 郑翔龙蒋赞
Owner GUANGZHOU BLUE MOON IND
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