Hollow polymer plastic microspheres with micropores on the surface, preparation method and application thereof
A technology of polymers and micropores, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the inconvenience of operation methods, increase the difficulty and uniformity of the preparation methods, and insufficiency Suitable for industrial production and other issues
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[0059] In a preferred embodiment of the invention, the preparation method comprises the following steps: firstly, adding an organic solvent into an aqueous solution in which a colloidal protective agent is dissolved, stirring at room temperature to disperse the organic solvent, and gradually increasing the temperature to prepare an oil-in-water droplet suspension; Comprises preparing a mixed solution of polymerization monomer, initiator and cross-linking agent; Dropwise adding the mixed solution into the suspension. By controlling the amount of organic solvent, the polymerization reaction is gradually carried out on the surface of the micro-droplets, thus forming a cross-linked polymer shell on the surface of the micro-droplets. At the initial stage of polymer shell formation, the organic solvent wrapped in the polymer shell slowly volatilizes by adjusting the system temperature, and hollow polymer plastic microspheres with micropores on the surface are formed. After filtering, wa...
Embodiment 1
[0080] A preparation method of cross-linked polymethyl methacrylate-n-butyl acrylate-2-ethylhexyl acrylate hollow polymer plastic microspheres with micropores on the surface, the specific operation steps are as follows:
[0081] (1) Put a reactor equipped with a stirrer and reflux condenser in a water bath, successively add 300.0g of polyvinyl alcohol 1788 (molecular weight of 1700, alcoholysis degree of 88%) water solution and 57.0g of methylcyclohexane into the reactor, adjust the stirring speed to 600rpm / min, stir at room temperature for 10 minutes, start to heat up and stabilize the system temperature at 75℃ to form a stable water-in-water.
[0082] (2) Put 12.0g n-butyl acrylate, 24.0g methyl methacrylate, 5.6g 2-ethylhexyl acrylate and 7.7g methylcyclopentadiene in a beaker, add 1.2g azodiisoheptylnitrile, and stir until diisoheptylnitrile is completely dissolved to form a uniform mixed solution.
[0083] (3) Drop the mixed solution of step (2) into the suspension of step (1...
Embodiment 2
[0091] A preparation method of cross-linked polymethyl methacrylate-n-butyl acrylate-2-ethylhexyl acrylate hollow polymer plastic microspheres with micropores on the surface, the specific operation steps are as follows:
[0092] (1) Put a reactor equipped with a stirrer and reflux condenser in a water bath, successively add 300.0g of aqueous solution of polyvinyl alcohol 1788 (molecular weight 1700, alcoholysis degree 88%) of 5% and 29.4g of cyclohexane into the reactor, adjust the stirring speed to 500rpm / min, stir at room temperature for 10 minutes, start to heat up and stabilize the system temperature at 60℃ to form a stable water-in-water.
[0093] (2) Put 8.0g of n-butyl acrylate, 24.0g of methyl methacrylate, 5.6g of 2-ethylhexyl acrylate and 5.7g of methylcyclopentadiene in a beaker, add 0.7g of benzoyl peroxide, and stir until benzoyl peroxide is completely dissolved to form a uniform mixed solution.
[0094] (3) Dropping the mixed solution of step (2) into the suspension ...
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