Polyvalent pneumococcus polysaccharide conjugate vaccine and preparation method thereof

Abstract

The invention provides a polyvalent pneumococcus polysaccharide conjugate vaccine and a preparation method thereof. For a polysaccharide-protein conjugate with immunogenicity, polysaccharide coming from streptococcus pneumoniae and protein form the conjugate, wherein the polysaccharide belongs to capsular polysaccharide with the serotype being 1, 2, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 16F, 17F, 18C, 19A, 19F, 20, 20F, 23A, 23F and 33F. For the conjugate provided by the invention, the serum coverage rate achieves 90% or above, and a protection effect can be generated on people of 2 months or older.

Description

technical field [0001] The present invention relates to a covalent conjugate, in particular to a conjugate obtained by covalently combining polysaccharides and proteins, a method for preparing the conjugate, and a method for preparing a Streptococcus pneumoniae vaccine. application. Background technique [0002] Streptococcus pneumoniae (Streptococcus pneumoniae) is a spherical Gram-positive bacterium under the genus Streptococcus, which is alpha hemolytic. Pneumonia caused by Streptococcus pneumoniae occurs most often in the very young or the elderly. Streptococcus pneumoniae is also a common cause of bacterial meningitis in adults. In addition, Streptococcus pneumoniae can also cause different kinds of diseases, such as: acute sinusitis, otitis media, osteomyelitis, septic arthritis, endocarditis, peritonitis, pericarditis and cellulitis, etc. [0003] Treatment of pneumococcal disease is mostly with beta-lactam antibiotics. In the early days, almost all strains of Str...

AI Technical Summary

Problems solved by technology

[0007] Among the existing marketed products, 15-valent vaccines have appeared, but the immunization coverage that such vaccines can achieve still needs to be further improved